Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Examples are disclosed that relate to display devices and mounting brackets for securing a bezel to a display device. In one example, a display device comprises a display unit and a bezel comprising at least one pocket. The display device comprises a mounting bracket comprising a display unit attachment portion affixed to the display unit and at least one tongue that extends at least partially into the at least one pocket. Adhesive binds the at least one tongue to at least one surface of the at least one pocket, thereby coupling the bezel to the display unit via the mounting bracket.

Abstract: Embodiments described herein relate to apparatus and techniques for aligning and coupling a sensor device to a wearable patch. A shoe apparatus is coupled to the wearable patch. The sensor device is coupled to the shoe apparatus via one or more connectors of the shoe apparatus. As the sensor device is inserted into the shoe apparatus, features of the shoe apparatus enable alignment of the sensor device with the shoe apparatus and the one or more connectors.

Abstract: Example multi-device storage systems, storage devices, and methods provide hosted services on peer storage devices. Storage devices include local memory resources, such as operating memory, remotely addressable memory, or logical mapping memory, and compute resources, such as a processor or coding engine. Each storage device is configured to communicate with a plurality of peer storage devices over an interconnect fabric. The storage devices identify requested hosted services from service host requests received through the interconnect fabric. The storage devices store a plurality of hosted services are to enable access to local memory resources and local compute resources for data management operations for the plurality of peer storage devices.

Abstract: Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Methods, systems, and other aspects for reconstructing data and rebuilding a failed storage device in a storage system using one or more functioning compute resources and/or storage resources of the failed storage device. For example, a method may include, responsive to a detection of a failed storage device in a storage system, locating data and redundancy information in functioning storage device(s) in the storage system for reconstructing data of the failed storage device; issuing peer-to-peer commands to the functioning storage device(s) to obtain the data and the redundancy information from the functioning storage device(s); and reconstructing the data of the failed storage device based on the data and the redundancy information obtained from the functioning storage device(s), wherein a functioning compute resource of the failed computing device at least partially performs one or more of the locating, issuing, and reconstructing.

Abstract: Systems and methods according to one or more embodiments are provided for a hum reduction circuit implemented to provide a ground path between an audio generating device and a powered headset. In one example, a system includes a jack configured to accept a plug comprising a first electrical ground connection. The system also includes a switch coupled to the jack at a first end and coupled to second electrical ground connection at a second end. The system also includes the switch is configured to couple to the first electrical ground at the first end. The system further includes a bias control signal coupled to the switch, configured to control a switch bias, where a first switch bias electrically couples the first electrical ground to the second electrical ground, and a second switch bias electrically decouples the first electrical ground from the second electrical ground.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Example multi-device storage systems, storage devices, and methods provide hosted services on peer storage devices. Storage devices include local memory resources, such as operating memory, remotely addressable memory, or logical mapping memory, and compute resources, such as a processor or coding engine. Each storage device is configured to communicate with a plurality of peer storage devices over an interconnect fabric. The storage devices identify requested hosted services from service host requests received through the interconnect fabric. The storage devices store a plurality of hosted services are to enable access to local memory resources and local compute resources for data management operations for the plurality of peer storage devices.

Abstract: Bridge connectors for coupling a control device to a biometric sensor are disclosed. A bridge connector includes a first data port configured to be removably coupled to the control device and a second data port configured to be removably coupled to the biometric sensor. The bridge connector also includes a flexible planar body, including at least one signal pathway interconnecting the first data port to the second data port. The first and second data ports are configured to transmit biometric data from the biometric sensor to the control device, using the at least one signal pathway. Further, the bridge connector is configured to provide a voltage to the biometric sensor from a power source in the control device, or the biometric sensor is configured to transmit at least some of the biometric data to the control device in a passive manner without consuming power from the power source.

Abstract: The present invention features the use of chimeric CD3 proteins to modulate T cell Receptor (TCR) signaling. Specifically, the invention is based, in part, on the discovery that multiple chimeric CD3 proteins (e.g., CD3delta, CD3gamma, and CD3 epsilon) having all or most of their extracellular domain fused to more than one antigen binding domain can activate the TCR in the presence of one or more cognate antigens. The invention is further based on the observation that the above chimeric proteins can be potentiated through the inclusion of a co-stimulatory domain in the intracellular portion of the chimeric molecule. Thus, the preferred elements of the engineered signaling complexes of the invention include more than one antigen binding domain, an extracellular domain derived from one of the above CD3 proteins, and an intracellular co-stimulatory domain.

Abstract: A method includes accessing, in response to initiating an operation targeting data, auxiliary mapping data to determine whether the auxiliary mapping data includes an indication of a key associated with a node of a hierarchical data structure that is associated with the data. In response to the auxiliary mapping data including the indication of the key, the data is accessed from a memory using a node identification associated with the key. In response to the auxiliary mapping data not including the indication of the key, the data is accessed from the memory using a search operation.

Abstract: A system is disclosed for facilitating communications between certified on-board avionics control functions and one or more uncertified remote client applications. The system includes an avionics data access function (ADAF), which acts as a multi-mode data acquisition agent for the onboard avionics control functions and serves the requests from the remote client applications. In some cases, ADAF comprises a separate space- and time-partitioned module, which handles retrieving data from the onboard avionics and transmitting the data to the remote client application(s) in the appropriate format.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Example multi-device storage systems and methods provide disaggregated read/write operations. Read and/or write data requests are received from a host system at a storage controller for a plurality of storage devices. A target service host storage device is identified that hosts a target portion of a logical map of storage locations distributed among the plurality of storage devices. The target service host storage device identifies a destination storage device corresponding to a target location for the request. A data transfer from the host system to the destination storage device is processed for the request and the logical map of the target service host device is updated. The target service host storage device and the destination storage device may be different storage devices among the plurality of storage devices.

Abstract: Bridge connectors employing flexible planar bodies having signal pathways coupling control devices with biometric sensors are disclosed. Sensors are placed in contact with a patient to detect a health condition and generate an output signal based on the health condition. A control device is linked to the sensors to receive the output signal for collection, analysis, storage, display, and/or subsequent transfer. A bridge connector includes a planar body with predetermined flexibility and signal pathways extending between data ports. By removably coupling the bridge connector to the control device and the sensors secured to the patient, the control device may be physically supported by the patient with minimal discomfort and low-cost biometric sensors may be used. In this manner, sensor replacement costs are reduced and the useful lives of the sensors can be maximized as the designed flexibility of the bridge connector facilitates removable coupling with the biometric sensors.