Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, Darier's disease, scleroderma, cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Methods for providing a flight management service in a cloud computing environment, the method includes: receiving, an object request by a server from a mobile device wherein the server is located in the cloud computing environment including: at least a flight management system (FMS) connected to a stateless object; processing, by the connected FMS hosted by the server, the object request generating a resource object for a particular flight plan wherein the resource object includes a data set; storing, by the connected FMS, the data set at the stateless object in the cloud environment; and sending, by the server, an object response from the connected FMS to the mobile device, for accessing the data set of the stateless object for the particular flight plan.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Systems and methods are provided for query and index optimization for retrieving data in instances of a formulation data structure from a database. The methods include presenting an information source for searching for the presence of formulations and generating formulation data from field entries. The formulation data is associated with found formulations. The methods include generating an instance of a formulation data structure. The instance of the formulation data structure associates the information source with the found formulations. The methods include creating optimized index data from retrieved data in the instance of the formulation data structure. The optimized index data includes a mapping between potential search-field terms and the formulation data, and is grouped based on a predicted access pattern.

Abstract: A storage device may be configured to determine a delay associated with execution of a read operation responsive to a read command for data stored at the storage device. The storage device may send a notification that indicates the delay, that includes data that indicates a duration of the delay, or both. In response to receiving the notification, an access device may be configured to generate a second read command for redundant associated with data stored at the storage device.

Abstract: Systems and methods according to one or more embodiments are provided for a hum reduction circuit implemented to provide a ground path between an audio generating device and a powered headset. In one example, a system includes a jack configured to accept a plug comprising a first electrical ground connection. The system also includes a switch coupled to the jack at a first end and coupled to second electrical ground connection at a second end. The system also includes the switch is configured to couple to the first electrical ground at the first end. The system further includes a bias control signal coupled to the switch, configured to control a switch bias, where a first switch bias electrically couples the first electrical ground to the second electrical ground, and a second switch bias electrically decouples the first electrical ground from the second electrical ground.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: An apparatus includes a data sequencing engine configured to receive first data and an identification of a first data container associated with the first data and to allocate the first data to a first data stream of multiple data streams based on the identification. The apparatus further includes at least one memory configured to store the first data container. The data sequencing engine is further configured to cause the at least one memory to send data in the first data stream to a flash memory in response to detecting a data size of the first data stream satisfies a threshold.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Among other things to provide exchanged based lifetime income stream by packaging annuities and other guaranteed payments into a pooled fund to be sold and traded as exchange based funds. Two approaches are planned, one with a closed pool of representative annuitants the other with an open pool of actual annuitants. The closed pool will determine the optimal weights of Male/Female and Unisex investments and the appropriate timing to rebalance to the actual annuitants as well as cash management and threshold for capital raises. The open pool will calculate the threshold for capital raises, cash management. Secondary market will supply liquidity through a process of qualifying the investor's health to allow for exchange in the secondary market. A machine based microprocessor with proprietary algorithm will adjust for different aged investors and contract features in the same fund. Exchanges will be through either existing exchanges or a web based bid/ask exchange.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A wireless transaction request may be received by a vehicle from a retailer. The vehicle may validate that the vehicle is located in proximity to the retailer and may receive confirmation of the request from a vehicle occupant. The vehicle may also initiate a payment for the transaction with a server, responsive to the confirmation of the request and validation of the vehicle location. Communications between the vehicle and the retailer may be performed using Dedicated Short Range Communications (DSRC). The identity of the vehicle occupant may be confirmed using biometric sensors. The payment transaction may be performed using the Automated Clearing House (ACH) electronic network to avoid credit card interchange fees.

Abstract: A fuel transfer adapter for a fuel cartridge, the fuel transfer adapter comprising: an adapter body; at least one fuel filling channel through said adapter body for the passage of fuel from a valve of the fuel cartridge to a fuel tank of an appliance through a filling port of said fuel tank; a fuel cartridge engaging portion at one end of the adapter body, for engaging the adapter body with the valve of the fuel cartridge; and, a port engaging portion at the other end of the adapter body for releasably engaging with the filling port, whereby the fuel transfer adapter incorporates at least one vent for the passage of vapour from the fuel tank to the atmosphere, said at least one vent being configured, in use, to transfer vapour displaced from the fuel tank by the fuel entering therein to the atmosphere.