Abstract: The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: An apparatus comprises a storage device and a device controller operatively coupled with the storage device. The device controller comprises a memory that stores an application. The application stored on the memory comprises instructions. When executed, the instruction direct the device controller to receive a storage request comprising content. The device controller retrieves a storage device policy from the memory that indicates a set of storage locations on the storage device. The device controller selects one of the storage locations on the storage device based on the storage device policy. The device controller stores the content on the storage device at the selected storage location. The device controller records storage information for the content that indicates the selected location on the memory.

Abstract: A sanding, grinding, buffing or deburring tool includes an elongated cylindrical housing, wherein a proximal end is open, and a distal end includes an exhaust port that cooperates with a vacuum system to pull air through the housing and into the exhaust port. A motor is mounted in the housing, and includes a shaft coupled to a removable tip configured to perform one or more of: sanding, grinding, deburring or buffing. A removable truncated cone-shaped vent has a distal end attached to the housing, and a proximal end having an opening through which the removable tip protrudes and a ridge configured to support to a workpiece while being sanded, ground, buffed or deburred. The vacuum system draws air into the housing through the vent opening, past the removable tip and motor, and into the exhaust port, thereby removing dust and cutting debris and cooling the removable tip and the motor.

Abstract: The present application relates to halo-substituted aza-heteroaryl compounds of Formula (I): (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.

Abstract: The present application relates to halo-substituted heterocyclic compounds of Formula (I): or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.

Abstract: A divider screen is described in various embodiments having various numbers of screens and screen members, and various arrangements. One divider screen has a post, a first screen member and a second screen member. The first screen member has a first screen attached to a first rotation member. The first rotation member is rotatably located to the post with the first screen member rotatable about the post. The second screen member has a second screen attached to a second rotation member. The second rotation member is rotatably located to the post with the second screen member rotatable about the post. The first and second screen members are arrangeable in at least a closed 0° position, an open 90° position, and an open 180° position.

Abstract: A method includes making a determination at a user device to transition the user device to a standby mode. The method includes sending a message from the user device to a server of a service provider in response to the determination, where the service provider provides a service to the user device. The method includes receiving, in response to the message, a content stream at the user device. The method includes sending video content generated from the content stream to a display device while the user device is in the standby mode. The method also includes, in response to a time in the standby mode exceeding a threshold, transmitting a second message to the server from the user device. In response to the second message, receipt of the content stream ceases.

Abstract: The present application relates to substituted amino aza-heteroaryl compounds of Formula (I) and substituted aza-heteroaryl compounds of Formula II or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.

Abstract: An apparatus comprises a storage device and a device controller operatively coupled with the storage device. The device controller comprises a memory that stores an application. The application stored on the memory comprises instructions. When executed, the instruction direct the device controller to receive a storage request comprising content. The device controller retrieves a storage device policy from the memory that indicates a set of storage locations on the storage device. The device controller selects one of the storage locations on the storage device based on the storage device policy. The device controller stores the content on the storage device at the selected storage location. The device controller records storage information for the content that indicates the selected location on the memory.

Abstract: The present disclosure relates to, among other things, compositions and methods for improving hardness without using excessive compression forces, thereby preserving compression-sensitive or pressure-sensitive active ingredients. The present disclosure also relates to compositions and methods for preparing post-compression hardening materials having a high tensile strength at low water activity.

Abstract: Systems and methods for casting solid propellants include a mandrel for forming geometric features in a perforation of a propellant grain. In various embodiments, the mandrel includes a frangible portion that is removed from the propellant grain after the propellant grain has cured around the mandrel. A second portion of the mandrel may be left behind in the propellant grain. The mandrel may include a support structured disposed in the through hole of the mandrel. The support structure may include a plurality of longitudinal channels for directed exhaust gasses through the mandrel upon ignition of the propellant grain.

Abstract: An implantable device for intratumoral delivery of a therapeutic agent is provided. The implantable device includes a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents. The therapeutic agent(s) includes one or more antibodies. Optionally, the polymer matrix includes one or more excipients. The polymer matrix includes a hydrophobic polymer. The hydrophobic polymer has a melt flow index of from about 0.2 to about 100 grams per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms and/or a melting temperature of from about 20° C. to about 70° C. as determined in accordance with ASTM D3418-21.

Abstract: An apparatus comprises a storage device and a device controller operatively coupled with the storage device. The device controller comprises a memory that stores an application. The application stored on the memory comprises instructions. When executed, the instruction direct the device controller to receive a storage request comprising content. The device controller retrieves a storage device policy from the memory that indicates a set of storage locations on the storage device. The device controller selects one of the storage locations on the storage device based on the storage device policy. The device controller stores the content on the storage device at the selected storage location. The device controller records storage information for the content that indicates the selected location on the memory.

Abstract: In an embodiment, a storage device is provided. A device controller with a memory is coupled with the storage device. The memory stores an application with instructions that direct the controller to receive a storage device policy. The instructions further direct the controller to store content from a storage request in accordance with the storage device policy, and record storage information, including at least a content identifier, to the memory. Subsequent to storing the content, the instructions further direct the controller to retrieve the content according to the storage information received in a storage request. According to an implementation, the instructions further provide instruction to refuse a delete request in accordance with the storage information. According to an implementation, the instructions provide direction to store the storage information at a remote location.

Abstract: Systems and methods for casting solid propellants include a mandrel for forming geometric features in a perforation of a propellant grain. In various embodiments, the mandrel includes a frangible portion that is removed from the propellant grain after the propellant grain has cured around the mandrel. A second portion of the mandrel may be left behind in the propellant grain. The mandrel may include a support structured disposed in the through hole of the mandrel. The support structure may include a plurality of longitudinal channels for directed exhaust gasses through the mandrel upon ignition of the propellant grain.

Abstract: A solid propellant propulsion motor may comprise: a forward propellant grain extending along a longitudinal axis of a motor case between a forward end of the motor case and a first burn inhibitor layer in the motor case; the first burn inhibitor layer disposed axially adjacent to the forward propellant grain; an aft propellant grain disposed axially adjacent to the first burn inhibitor layer; a second burn inhibitor layer disposed axially adjacent to an aft end of the aft propellant grain; and an ablative material layer disposed on a radially inner surface of the aft propellant grain.

Abstract: A method includes receiving data images of patient medications. The method also creates a training set using the received data images. The method also includes training a machine learning system using the training set. The machine learning system is trained to monitor shipment and inventory of the patient medications, patient enrollment in medical trials, and a distribution of the patient medications. The method also includes applying the trained machine learning system with monitoring results of the shipment and inventory of the patient medications, the patient enrollment in the medical trials, and the distribution of the patient medications.

Abstract: A photodynamic therapy apparatus for local targeting in cancer treatment capable of treating various types of cancers or tumors. An endoscope is placed in the center of an end portion of a probe used in photodynamic therapy and a plurality of optical fibers are arranged along the edge thereof, so that a lesion site is irradiated with a plurality of lights while the plurality of optical fibers of the probe receive lights from individual light sources, respectively, to perform light irradiation individually. An apparatus is disclosed, wherein unnecessary damage to normal tissues is minimized by controlling light irradiation regions, for instance, by defining light irradiation regions encompassing a lesion site from an image provided in real time through an endoscope disposed at an end portion of a probe and allowing only individual light sources irradiating the defined light irradiation regions to emit lights to achieve local light irradiation.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An intravaginal ring device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt. % to about 60 wt. % and/or a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.