Abstract: The present application is directed to compounds of Formula I: (I) compositions comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: Methods and memory circuits for altering a magnetic direction of a magnetic memory cell using picosecond electric current pulses are disclosed. One method includes directing a first electric current pulse through the magnetic memory cell that includes a ferrimagnetic material layer to heat the ferrimagnetic material layer to toggle a magnetic direction of the ferrimagnetic material layer from a first magnetic direction to a second magnetic direction.

Abstract: The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration.

Abstract: Methods and systems of optimization of and Integrated Circuit (IC) design disclosed herein result in a power efficient clustering of circuit devices. The methods may depart from the conventional geometric clustering using a nearest neighbor approach when wiring flops to local clock buffers. To reduce the number of clock-gaters, the methods in one embodiment use a grouping of flops wired to a common clock-gater to form nodes, which are then wired to the local clock buffers based on a load-balancing process. In another embodiment, the methods use a local cleanup process to rewire the nodes between neighboring clock buffers to further reduce the amount of clock-gaters.

Abstract: A method of forming a non-pneumatic tire is provided that includes the steps of providing an outer shear band ring (56) and an intermediate section (14) that has a supporting structure (16). The intermediate section (14) is collapsed from an uncollapsed state to a collapsed state. The intermediate section in the collapsed state is inserted inside of the outer shear band ring such that the outer shear band ring is located outward from the intermediate section in a radial direction of the tire. Compression of the intermediate section (14) is released when the intermediate section (14) is inside of the outer shear band ring (56) so that the intermediate section returns to the uncollapsed state from the collapsed state. In one embodiment, the compressing step of the intermediate section (14) is performed by a compression device (68) that has a plurality of gripping members.

Abstract: An adapter apparatus includes a generally cylindrical adapter body 14 including a channel 16 extending axially therethrough, the adapter body having an interior surface bounding the channel, and an exterior surface 18, a generally circular external cross section and an interior cross section which is adapted to engage at least one object 10, the external surface being formed from a material which is capable of supporting a scanning or testing apparatus at a constant distance from the origin of the circle forming the external cross section.

Abstract: Techniques for rules-based content management are provided. Video on demand content is collected from a variety of sources. Business rules embedded within metadata can be retrieved where the business rules control processing and delivery of the video on demand content. The video on demand content may be selectively packaged in response to the business rules and the metadata to generate packaged video on demand content. A server can distribute the packaged video on demand content to devices. A priority for processing the packaged video on demand content can be based on a quality of service parameter and based on the metadata, the business rules, and a license embedded within the metadata where the license describes the priority. Other embodiments are disclosed.

Abstract: A method of forming a non-pneumatic tire (10) is provided that includes the steps of providing an outer shear band ring (12), an intermediate section (14) with a supporting structure (16), and an inner shear band ring. The intermediate section (14) is positioned inside of the outer shear band ring (12) such that the outer shear band ring is located outward from the intermediate section in a radial direction of the tire. A hub (20) is positioned inside of the intermediate section such that the intermediate section (14) is located outward from the hub (20) in the radial direction.

Abstract: A method of forming a non-pneumatic tire is provided that includes the steps of providing an outer shear band ring (12) that has an inner diameter. An intermediate section (14) is provided that has a supporting structure. An outer diameter (102) of the intermediate section (14) in the uncompressed state is greater than the inner diameter (70) of the outer shear band ring (12). The intermediate section is compressed from the uncompressed state to a compressed state, and is inserted inside of the outer shear band ring (12). Compression of the intermediate section is released when the intermediate section is inside of the outer shear band ring, and the intermediate section (14) moves from the compressed state to a state of interference fit with the outer shear band ring (12).

Abstract: Many embodiments provide a hybrid data processing system (HySDS) of an end-to-end geodetic imaging data system enabling near-real-time science, assessment, response, and rapid recovery. The HySDS may be an operation data processing system that integrates data from many different geodetic data sources and/or sensors, including interferometric synthetic aperture radar (InSAR), GPS, pixel tracking, seismology, and/or modeling, and processes the data to generate actionable high quality science data products. The HySDS may provide for an automated imaging and analysis capabilities that is able to handle the imminent increases in raw data from new and existing geodetic monitoring sensor systems.

Abstract: An adapter apparatus includes a generally cylindrical adapter body 14 including a channel 16 extending axially therethrough, the adapter body having an interior surface, bounding the channel, and an exterior surface 18, a generally circular external cross section and an interior cross section which is adapted to engage at least one object 10, the external surface being formed from a material which is capable of supporting a scanning or testing apparatus at a constant distance from the origin of the circle forming the external cross section.

Abstract: Disclosed herein are systems and methods to construct a symmetric clock-distribution H-tree in upper layers of an integrated circuit (IC), which may have complicated routing and/or placement blockages. The systems and methods disclosed herein may implement concomitant bottom-up wiring and top-down rewiring to achieve a clock-distribution tree symmetrically balanced across all of the hierarchical levels while respecting the complicated routing and/or placement blockages. Such symmetrically balanced clock-tree ensures that a clock-signal reaches all of the clock-sinks simultaneously or near simultaneously thereby minimizing clock-skew across the clock-sinks. The minimal skew symmetric clock-distribution H-tree may therefore be used for higher performance and high speed ICs.

Abstract: An energetic ignition arrangement may comprise a pressure vessel arrangement, comprising a pressure vessel, and an ignition system arrangement. The ignition system arrangement may comprise an ignitor housing coupled to the pressure vessel and defining a sealing aperture, a seal disposed in the sealing aperture, and an electric match extending through the ignitor housing, wherein at least the ignitor housing and the pressure vessel are reusable after the energetic ignition arrangement has been employed in an ignition event.

Abstract: Polymers comprising polyetheretheretherketone and polyetherdiphenyletherketone and polymers comprising polyetheretheretherketone and polyetheretherethersulphone are described which have advantageous Tn and/or Tg properties.

Abstract: Aspects of the subject disclosure may include, for example, a method including providing, by a processor in a dongle coupled to a display device, a graphical user interface at the display device, and transmitting a message to an authentication server in accordance with authentication information stored in a storage device of the dongle and an input via the graphical user interface. The method also includes obtaining an authentication confirmation; obtaining content from a content server; and recording the content in accordance with a second input via the graphical user interface. The recorded content is transmitted for storage at a storage server. The display device communicates with equipment of a video provider that is associated with a service area. In accordance with the authentication confirmation, the processor is authorized to obtain the content based on the location of the dongle relative to the service area. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, a device that performs operations including receiving user input associated with a group of emergency alert service messages, assigning a plurality of severity codes to the group of emergency alert service messages according to the user input, each of the plurality of severity codes indicating a presentation format, determining a first location of a mobile communication device, determining a second location of a premises of a user of the mobile communication device. The operations can also include, responsive to detecting a first emergency alert service message associated with the first location, determining a first severity code of the plurality of severity codes assigned to the first emergency alert service message and providing the first emergency alert service message to the mobile communication device for presentation in a first format according to the first severity code. Other embodiments are disclosed.

Abstract: Techniques for rules-based content management are provided. Video on demand content is collected from a variety of sources. Business rules embedded within metadata can be retrieved where the business rules control processing and delivery of the video on demand content. The video on demand content may be selectively packaged in response to the business rules and the metadata to generate packaged video on demand content. A server can distribute the packaged video on demand content to devices. A priority for processing the packaged video on demand content can be based on a quality of service parameter and based on the metadata, the business rules, and a license embedded within the metadata where the license describes the priority. Other embodiments are disclosed.

Abstract: A lavatory cleansing block including: an alkane sulfonate; a carboxymethylcellulose; a hydrophobe; and optionally a dye, wherein the alkane sulfonate is present in an amount of 15 to 40% by weight of the total block, the weight ratio of alkane sulfonate to carboxymethylcellulose is 3:1 to 8:1 and the total weight of the block is less than 25 g.