Abstract: A method for prohibiting and/or treating an eye condition is provided. The method comprises inserting an implantable device into a suprachoroidal space of a patient. The device comprises a core defining an outer peripheral surface. The core comprises a core polymer matrix within which is dispersed a therapeutic agent, the polymer matrix containing an ethylene vinyl acetate copolymer.

Abstract: The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: A solid propellant propulsion motor may comprise: a forward propellant grain extending along a longitudinal axis of a motor case between a forward end of the motor case and a first burn inhibitor layer in the motor case; the first burn inhibitor layer disposed axially adjacent to the forward propellant grain; an aft propellant grain disposed axially adjacent to the first burn inhibitor layer; a second burn inhibitor layer disposed axially adjacent to an aft end of the aft propellant grain; and an ablative material layer disposed on a radially inner surface of the aft propellant grain.

Abstract: An implantable device for prohibiting and/or treating an inflammatory eye condition is provided. The device comprises a core defining an outer peripheral surface. The core comprises a core polymer matrix within which is dispersed at least a steroidal agent, the polymer matrix containing an ethylene vinyl acetate copolymer.

Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.

Abstract: A control system for an ejection system may comprise an ejection seat, a canopy jettison system, a sensor, a controller, and a tangible, non-transitory memory configured to communicate with the controller, the tangible, non-transitory memory having instructions stored thereon that, in response to execution by the controller, cause the controller to perform operations comprising receiving an eject command, polling the sensor for a sensor data, receiving the sensor data, passing the sensor data to a time delay logic, determining via the time delay logic a time delay based on the sensor data, and actuating the ejection seat based on the time delay.

Abstract: The present application relates to compounds of Formula I or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Abstract: A solid-propellant gas generator assembly may comprise a bulkhead having an orifice disposed in a housing. The bulkhead may be disposed between a first end and a second end of the housing. The bulkhead and the first end may define a propellant cavity. The bulkhead and the second end may define a pressure chamber. A fast burning solid-propellant may be disposed in the propellant cavity. The solid-propellant gas generator assembly may be configured to replace a slow burning solid-propellant gas generator system in a solid-propellent gas generator system.

Abstract: The present disclosure relates to a formulation for a wide variety of poorly soluble drugs to improve bioavailability using a solid self-emulsifying drug delivery system. Compositions of the present disclosure can be used for improved delivery of hydrophobic or lipophilic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals, and diagnostic agents.

Abstract: An apparatus comprises a storage device and a device controller operatively coupled with the storage device. The device controller comprises a memory that stores an application. The application stored on the memory comprises instructions. When executed, the instruction direct the device controller to receive a storage request comprising content. The device controller retrieves a storage device policy from the memory that indicates a set of storage locations on the storage device. The device controller selects one of the storage locations on the storage device based on the storage device policy. The device controller stores the content on the storage device at the selected storage location. The device controller records storage information for the content that indicates the selected location on the memory.

Abstract: A method includes making a determination at a user device to transition the user device to a standby mode. The method includes sending a message from the user device to a server of a service provider in response to the determination, where the service provider provides a service to the user device. The method includes receiving, in response to the message, a content stream at the user device. The method includes sending video content generated from the content stream to a display device while the user device is in the standby mode. The method also includes, in response to a time in the standby mode exceeding a threshold, transmitting a second message to the server from the user device. In response to the second message, receipt of the content stream ceases.

Abstract: In an embodiment, a storage device is provided. A device controller with a memory is coupled with the storage device. The memory stores an application with instructions that direct the controller to receive a storage device policy. The instructions further direct the controller to store content from a storage request in accordance with the storage device policy, and record storage information, including at least a content identifier, to the memory. Subsequent to storing the content, the instructions further direct the controller to retrieve the content according to the storage information received in a storage request. According to an implementation, the instructions further provide instruction to refuse a delete request in accordance to the storage information. According to an implementation, the instructions provide direction to store the storage information at a remote location.

Abstract: The present invention relates to a photodynamic therapy apparatus for local targeting in cancer treatment. More specifically, an endoscope is placed in the center of an end portion of a probe used in photodynamic therapy and a plurality of optical fibers are arranged along the edge thereof, so that a lesion site is irradiated with a plurality of lights while the plurality of optical fibers of the probe receive lights from individual light sources, respectively, to perform light irradiation individually. Furthermore, the present invention relates to an apparatus, wherein unnecessary damage to normal tissues is minimized by controlling light irradiation regions, for instance, by defining light irradiation regions encompassing a lesion site from an image provided in real time through an endoscope disposed at an end portion of a probe and allowing only individual light sources irradiating the defined light irradiation regions to emit lights to achieve local light irradiation.

Abstract: The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Abstract: A method includes making a determination at a user device to transition the user device to a standby mode. The method includes sending a message from the user device to a server of a service provider in response to the determination, where the service provider provides a service to the user device. The method includes receiving, in response to the message, a content stream at the user device. The method includes sending video content generated from the content stream to a display device while the user device is in the standby mode. The method also includes, in response to a time in the standby mode exceeding a threshold, transmitting a second message to the server from the user device. In response to the second message, receipt of the content stream ceases.

Abstract: Systems and methods for casting solid propellants include a mandrel for forming geometric features in a perforation of a propellant grain. In various embodiments, the mandrel includes a frangible portion that is removed from the propellant grain after the propellant grain has cured around the mandrel. A second portion of the mandrel may be left behind in the propellant grain. The mandrel may include a support structured disposed in the through hole of the mandrel. The support structure may include a plurality of longitudinal channels for directed exhaust gasses through the mandrel upon ignition of the propellant grain.

Abstract: The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Abstract: A lavatory cleansing block including: an alkane sulfonate; a carboxymethylcellulose; a dye; and a hydrophobe; wherein the weight ratio of carboxymethylcellulose to dye in the block is 1.5:1 to 0.8:2 and wherein the block is substantially free of guar gum.

Abstract: A divider screen is described in various embodiments having various numbers of screens and screen members, and various arrangements. One divider screen has a post, a first screen member and a second screen member. The first screen member has a first screen attached to a first rotation member. The first rotation member is rotatably located to the post with the first screen member rotatable about the post. The second screen member has a second screen attached to a second rotation member. The second rotation member is rotatably located to the post with the second screen member rotatable about the post. The first and second screen members are arrangeable in at least a closed 0° position, an open 90° position, and an open 180° position.

Abstract: The present application is directed to compounds of Formula I: compositions comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.