Patents by Inventor Brian Zambrowicz

Brian Zambrowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel human endothelin converting enzyme-like proteins and polynucleotides encoding the same
    Publication number: 20050143569
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: November 15, 2004
    Publication date: June 30, 2005
    Inventors: Gregory Donoho, C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human transporter proteins and polynucleotides encoding the same
    Publication number: 20050142588
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: October 7, 2004
    Publication date: June 30, 2005
    Inventors: D. Walke, Nathaniel Wilganowski, Yi Hu, James Kieke, Brian Zambrowicz, Jean-Pierre Revelli, C. Turner
  • Novel human membrane proteins and polynucleotides encoding the same
    Publication number: 20050124802
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacongenomic applications.
    Type: Application
    Filed: September 16, 2004
    Publication date: June 9, 2005
    Inventors: C. Turner, Brian Mathur, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human thrombospondin-like proteins and polynucleotides encoding the same
    Publication number: 20050123955
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 24, 2004
    Publication date: June 9, 2005
    Inventors: C. Turner, Erin Hilbun, Gregory Donoho, Glenn Friedrich, Alejandro Aubin, Brian Zambrowicz, Arthur Sands
  • Methods and compositions for defining gene function
    Publication number: 20050118710
    Abstract: A process for producing and analyzing insertionally mutated cell clones is provided. Cells incorporating insertional mutations are provided. A collection of insertionally mutated cell clones is also provided.
    Type: Application
    Filed: September 30, 2004
    Publication date: June 2, 2005
    Inventors: Gwenn Hansen, Alejandro Abuin, Brian Zambrowicz, Carl Friddle, William Dempsey
  • Human ATPase proteins and polynucleotides encoding the same
    Patent number: 6900046
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: May 31, 2005
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Erin Hilbun, Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Indexed library of cells containing genomic modifications and methods of making and utilizing the same
    Publication number: 20050095620
    Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
    Type: Application
    Filed: August 11, 2004
    Publication date: May 5, 2005
    Inventors: Brian Zambrowicz, Glenn Friedrich, Allan Bradley, Arthur Sands
  • Novel human neurexin-like proteins and polynucleotides encoding the same
    Publication number: 20050096462
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: November 29, 2004
    Publication date: May 5, 2005
    Inventors: C. Turner, Erin Hilbun, Gregory Donoho, John Scoville, Frank Wattler, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Vectors for gene mutagenesis and gene discovery
    Publication number: 20050095713
    Abstract: Novel vectors are described that incorporate, inter alia, a novel 3? gene trap cassette which can be used to efficiently trap and identify previously unknown cellular genes. Vectors incorporating the described 3? gene trap cassette find particular application in gene discovery and in the production of mutated cells and animals.
    Type: Application
    Filed: August 11, 2004
    Publication date: May 5, 2005
    Inventors: Brian Zambrowicz, Glenn Friedrich, Stan Lilleberg, Arthur Sands
  • Novel human ion channel proteins
    Publication number: 20050089887
    Abstract: The present invention provides a novel family of human ion channel proteins (ICPs). The invention additionally provides for agonists, antagonists, antibodies, antisense molecules that are specific for the ICPs, and further provides genetically engineered expression vectors for the ICPs and host cells comprising the same. The invention further provides for processes for identifying/producing molecules that effect ICP activity that comprise the use of the disclosed ICPs or genes encoding the same.
    Type: Application
    Filed: June 4, 2004
    Publication date: April 28, 2005
    Inventors: Alexander Turner, Andrew Olson, Brian Zambrowicz, Glenn Friedrich, Arthur Sands
  • Novel human phospholipases and polynucleotides encoding the same
    Publication number: 20050089886
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: June 4, 2004
    Publication date: April 28, 2005
    Inventors: Yi Hu, Boris Nepomnichy, Gregory Donoho, Erin Hilbun, C. Turner, Alejandro Abuin, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human 7TM protein and polynucleotides encoding the same
    Publication number: 20050090000
    Abstract: The nucleotide and amino acid sequences of a novel human G protein-coupled receptor (NGPCR) is disclosed. The NGPCR is somewhat similar to the vasopressin G protein-coupled receptor family, and is preferentially expressed in the hypothalamus.
    Type: Application
    Filed: August 26, 2004
    Publication date: April 28, 2005
    Inventors: C. Turner, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Novel human protease inhibitor-like proteins and polynucleotides encoding the same
    Publication number: 20050089892
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: July 29, 2004
    Publication date: April 28, 2005
    Inventors: Gregory Donoho, C. Turner, Frank Wattler, Michael Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur Sands
  • Human proteases and polynucleotides encoding the same
    Patent number: 6881563
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: April 19, 2005
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Novel human proteins and polynucleotides encoding the same
    Publication number: 20050079580
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 7, 2004
    Publication date: April 14, 2005
    Inventors: C. Turner, Brian Zambrowicz, Glenn Friedrich, Michael Nehls, Arthur Sands
  • Novel human kinase proteins and polynucleotides encoding the same
    Publication number: 20050079530
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: September 8, 2004
    Publication date: April 14, 2005
    Inventors: Gregory Donoho, John Scoville, C. Turner, Glenn Friedrich, Brian Zambrowicz, Alejandro Abuin, Arthur Sands
  • Novel human secreted proteins and polynucleotides encoding the same
    Publication number: 20050069919
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Application
    Filed: June 1, 2004
    Publication date: March 31, 2005
    Inventors: D. Wade Walke, Nathaniel Wilganowski, John Scoville, Brian Zambrowicz
  • Arrayed collection of genomic clones
    Publication number: 20050066377
    Abstract: Novel collections of isolated genomic clones are described that are incorporated into gene targeting cloning vectors. The described collections find particular application in gene discovery, the production of mutated cells and animals, and gene activation.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 24, 2005
    Inventors: Brian Zambrowicz, Arthur Sands
  • Novel human 7TM proteins and polynucleotides encoding the same
    Publication number: 20050064466
    Abstract: The nucleotide and amino acid sequences of several novel human G protein coupled receptors are described.
    Type: Application
    Filed: July 6, 2004
    Publication date: March 24, 2005
    Inventors: D. Walke, John Scoville, Gregory Donoho, C. Turner, Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur Sands
  • Novel human polynucleotides and the polypeptides encoded thereby
    Publication number: 20050059060
    Abstract: Novel human polynucleotides are disclosed that correspond to human gene trapped sequences, or GTSs. The disclosed GTSs are useful for gene discovery and as markers for, inter alia, gene expression analysis, forensic analysis, and determining the genetic basis of human disease.
    Type: Application
    Filed: August 4, 2004
    Publication date: March 17, 2005
    Inventors: Michael Nehls, Brian Zambrowicz, Arthur Sands