Abstract: A computer implemented method for determining a dosage of edoxaban for administering to a patient, the method comprising: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric; processing the patient data with a dosage calculator to determine the dosage of edoxaban for administering to the patient, wherein the dosage calculator is derived from a plasma level prediction model; and indicating the dosage.

Abstract: A computer implemented method for determining a dosage of rivaroxaban for administering to a patient, the method comprising: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric; processing the patient data with a dosage calculator to determine the dosage of rivaroxaban for administering to the patient, wherein the dosage calculator is derived from a plasma level prediction model; and indicating the dosage.

Abstract: A method for administering a dosage of Apixaban to a patient for the treatment or prevention of thrombosis, the method comprising: administering a dosage of Apixaban to the patient, wherein the dosage of apixaban is determined by: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric of the patient; and processing, using one or more processors, the patient data with a dosage calculator to determine the dosage of Apixaban for the patient, wherein the dosage calculator is derived from a plasma level prediction model that predicts Apixaban drug plasma levels, and the dosage calculator determines the dosage for the patient based in part on the kidney function metric of the patient.

Abstract: A method for administering a dosage of Apixaban to a patient for the treatment or prevention of thrombosis, the method comprising: administering a dosage of Apixaban to the patient, wherein the dosage of apixaban is determined by: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric of the patient; and processing, using one or more processors, the patient data with a dosage calculator to determine the dosage of Apixaban for the patient, wherein the dosage calculator is derived from a plasma level prediction model that predicts Apixaban drug plasma levels, and the dosage calculator determines the dosage for the patient based in part on the kidney function metric of the patient.

Abstract: A terminal block configured to be mounted within an opening in a fire barrier. The terminal block includes a central body sized to be positioned in the opening. A lower mount extends outward from a first side of the central body. An upper mount extends outward from a second side of the central body. Mounting surfaces are positioned on each of the lower mount and the upper mount. Electrical conductors extend between the mounting surfaces on the lower mount and the upper mount with the electrical conductors configured to enable an electrical connection between first and second sections of power feed lines.

Abstract: A method of generating a dosage calculator for determining a dosage of a drug for administering to a patient, the method comprising: receiving population data comprising real population data, and/or simulated population data calculated using a pharmacokinetic-pharmacodynamic, PKPD, model for the drug; and training a machine learning dosage calculator using the population data.

Abstract: Disclosed are embodiments of a dough proofer for a commercial bakery that can receive dough pieces from a dough divider onto trays. Each tray has cups that hold dough pieces. The trays are moved through the proofer by a conveyor system. The proofer has a checkweigher. The checkweigher also uses the same conveyor system and has (1) a tray tipper that tips a tray of dough pieces to make the dough pieces fall out of the tray; (2) a row of gates under the tray to receive and hold the dough pieces and release the dough pieces so that they fall back into their original cups and tray; (3) a row of load cells associated with gates that produces weight data indicative of dough piece weights; and (4) a controller that controls the divider based upon the weight data so that the dough pieces exhibit a substantially uniform target weight.

Abstract: A machine that automatically performs select tests on candles includes a pedestal onto which a candle is positioned. The machine also includes cameras, focused on the candle, to collect thermal emission and visual data resulting from a “candle burn”. The machine is used in a “candle burn” test method.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: A method, apparatus, and system for leak detection in a distribution network having consumption meters. The distribution network is divided into zones having an upstream location and a downstream location. An upstream pressure sensor detects the upstream pressure at the upstream location and the downstream pressure sensor detects the detected downstream pressure at the downstream location. A downstream pressure lookup table is used to determine an expected pressure at each downstream location based on a range of hypothetical upstream pressures at the corresponding upstream location and consumption data from the consumption meters. The expected pressure and the detected downstream pressure at each downstream location are compared to determine if the calculated discrepancy exceeds a discrepancy threshold.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include generating a power plant model for operating the CCPP, determining whether at least two gas turbines in the power plant model generate a power output, and modeling a fuel consumption of the CCPP for a baseline split ratio between the at least two gas turbines. The method may also include determining whether the variant split ratio meets a quality threshold for the CCPP, and adjusting the CCPP to use the variant split ratio in response to the variant split ratio meeting the quality threshold.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: A forward concave trapezoidal seating system and methods are presented. Trapezoidal seats comprise a front side smaller than a rear side. The trapezoidal seats are aligned in a forward arc from a straight seat to a most-angled seat. A straight side of the straight seat is configured to substantially align with a center line of an aircraft fuselage. A most-angled side of the most-angled seat is angled inboard relative to the straight side, and the most-angled seat is outboard of the straight seat. A side unit is coupled to the most-angled side and supports the trapezoidal seats.

Abstract: A housing assembly includes a housing, a printed circuit board (PCB) contained in a housing, and a cup-shaped cap having an interior and a flange portion. A tall component extending from the PCB is covered by the cap such that the tall component is disposed in the interior of the cap and the flange portion of the cap engages the PCB. A vacuum is applied and while maintaining the vacuum, an encapsulant is introduced into the housing to a level so as to cover the PCB and certain other components not the relatively taller component(s). When the vacuum is released, a pressure differential between the environmental pressure and the vacuum remaining in the cap interior forces encapsulant into the cap interior to a level higher than that outside of the cap. A multi-level height potting process is achieved.

Abstract: A housing assembly includes a housing, a printed circuit board (PCB) contained in a housing, and a cup-shaped cap having an interior and a flange portion. A tall component extending from the PCB is covered by the cap such that the tall component is disposed in the interior of the cap and the flange portion of the cap engages the PCB. A vacuum is applied and while maintaining the vacuum, an encapsulant is introduced into the housing to a level so as to cover the PCB and certain other components not the relatively taller component(s). When the vacuum is released, a pressure differential between the environmental pressure and the vacuum remaining in the cap interior forces encapsulant into the cap interior to a level higher than that outside of the cap. A multi-level height potting process is achieved.

Abstract: The present invention relates to medicaments based on oligomeric forms of 3-hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1 and 2.

Abstract: A method, apparatus, and system for leak detection in a distribution network having consumption meters. The distribution network is divided into zones having an upstream location and a downstream location. An upstream pressure sensor detects the upstream pressure at the upstream location and the downstream pressure sensor detects the detected downstream pressure at the downstream location. A downstream pressure lookup table is used to determine an expected pressure at each downstream location based on a range of hypothetical upstream pressures at the corresponding upstream location and consumption data from the consumption meters. The expected pressure and the detected downstream pressure at each downstream location are compared to determine if the calculated discrepancy exceeds a discrepancy threshold.

Abstract: A forward concave trapezoidal seating system and methods are presented. Trapezoidal seats comprise a front side smaller than a rear side. The trapezoidal seats are aligned in a forward arc from a straight seat to a most-angled seat. A straight side of the straight seat is configured to substantially align with a center line of an aircraft fuselage. A most-angled side of the most-angled seat is angled inboard relative to the straight side, and the most-angled seat is outboard of the straight seat. A side unit is coupled to the most-angled side and supports the trapezoidal seats.

Abstract: A forward concave trapezoidal seating system and methods are presented. Trapezoidal seats comprise a front side smaller than a rear side. The trapezoidal seats are aligned in a forward arc from a straight seat to a most-angled seat. A straight side of the straight seat is configured to substantially align with a center line of an aircraft fuselage. A most-angled side of the most-angled seat is angled inboard relative to the straight side, and the most-angled seat is outboard of the straight seat. A side unit is coupled to the most-angled side and supports the trapezoidal seats.

Abstract: The present invention relates to medicaments based on oligomeric forms of 3-hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1 and 2.