Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A method for administering a dosage of Apixaban to a patient for the treatment or prevention of thrombosis, the method comprising: administering a dosage of Apixaban to the patient, wherein the dosage of apixaban is determined by: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric of the patient; and processing, using one or more processors, the patient data with a dosage calculator to determine the dosage of Apixaban for the patient, wherein the dosage calculator is derived from a plasma level prediction model that predicts Apixaban drug plasma levels, and the dosage calculator determines the dosage for the patient based in part on the kidney function metric of the patient.

Abstract: A method for administering a dosage of Cagrisema to a patient for the treatment of obesity, the method comprising: administering a dosage of Cagrisema to the patient, wherein the dosage of Cagrisema is determined by: receiving patient data relating to a patient, wherein the patient data includes patient weight data; and processing the patient data including the patient weight data with a dosage calculator to determine the dosage of Cagrisema for administering to the patient wherein the dosage calculator is derived from a pharmacokinetic, PK, model.

Abstract: A terminal block configured to be mounted within an opening in a fire barrier. The terminal block includes a central body sized to be positioned in the opening. A lower mount extends outward from a first side of the central body. An upper mount extends outward from a second side of the central body. Mounting surfaces are positioned on each of the lower mount and the upper mount. Electrical conductors extend between the mounting surfaces on the lower mount and the upper mount with the electrical conductors configured to enable an electrical connection between first and second sections of power feed lines.

Abstract: A computer implemented method for determining a dosage of semaglutide for administering to a patient for the treatment of obesity includes receiving patient data relating to a patient, wherein the patient data includes patient weight data; processing the patient data with a dosage calculator to determine the dosage of semaglutide for administering to the patient; and administering the dosage.

Abstract: A method of generating a dosage calculator for determining a dosage of a drug for administering to a patient, the method comprising: receiving population data comprising real population data, and/or simulated population data calculated using a pharmacokinetic-pharmacodynamic, PKPD, model for the drug; and training a machine learning dosage calculator using the population data.

Abstract: The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

Abstract: The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: Disclosed are embodiments of a dough proofer for a commercial bakery that can receive dough pieces from a dough divider onto trays. Each tray has cups that hold dough pieces. The trays are moved through the proofer by a conveyor system. The proofer has a checkweigher. The checkweigher also uses the same conveyor system and has (1) a tray tipper that tips a tray of dough pieces to make the dough pieces fall out of the tray; (2) a row of gates under the tray to receive and hold the dough pieces and release the dough pieces so that they fall back into their original cups and tray; (3) a row of load cells associated with gates that produces weight data indicative of dough piece weights; and (4) a controller that controls the divider based upon the weight data so that the dough pieces exhibit a substantially uniform target weight.

Abstract: A machine that automatically performs select tests on candles includes a pedestal onto which a candle is positioned. The machine also includes cameras, focused on the candle, to collect thermal emission and visual data resulting from a “candle burn”. The machine is used in a “candle burn” test method.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A method for treating obesity in a patient, the method comprising administering a dose of a GLP1 agonist to the patient in a treatment regimen effective to manage the patient's satiety and thereby effect a reduction in the patient's weight; and, in conjunction with the administration of the dose of GLP1 agonist, engaging in a directed digital therapeutic program that manages patient weight loss and the treatment regimen for the GLP1 agonist with the objective of achieving a predetermined target weight for the patient, wherein the patient achieves the target weight.

Abstract: There is a dosage regimen for amlodipine for use in the treatment of hypertension.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: A method, apparatus, and system for leak detection in a distribution network having consumption meters. The distribution network is divided into zones having an upstream location and a downstream location. An upstream pressure sensor detects the upstream pressure at the upstream location and the downstream pressure sensor detects the detected downstream pressure at the downstream location. A downstream pressure lookup table is used to determine an expected pressure at each downstream location based on a range of hypothetical upstream pressures at the corresponding upstream location and consumption data from the consumption meters. The expected pressure and the detected downstream pressure at each downstream location are compared to determine if the calculated discrepancy exceeds a discrepancy threshold.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include generating a power plant model for operating the CCPP, determining whether at least two gas turbines in the power plant model generate a power output, and modeling a fuel consumption of the CCPP for a baseline split ratio between the at least two gas turbines. The method may also include determining whether the variant split ratio meets a quality threshold for the CCPP, and adjusting the CCPP to use the variant split ratio in response to the variant split ratio meeting the quality threshold.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A forward concave trapezoidal seating system and methods are presented. Trapezoidal seats comprise a front side smaller than a rear side. The trapezoidal seats are aligned in a forward arc from a straight seat to a most-angled seat. A straight side of the straight seat is configured to substantially align with a center line of an aircraft fuselage. A most-angled side of the most-angled seat is angled inboard relative to the straight side, and the most-angled seat is outboard of the straight seat. A side unit is coupled to the most-angled side and supports the trapezoidal seats.