Patents by Inventor Bruce E. Maryanoff

Bruce E. Maryanoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazolone peptidomimetics as thrombin receptor antagonists
    Patent number: 6943149
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 13, 2005
    Assignees: Ortho McNeil Pharmaceutical, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists
    Patent number: 6936604
    Abstract: The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: August 30, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Alexey B. Dyatkin, William J. Hoekstra, Bruce E. Maryanoff
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Patent number: 6890939
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: May 10, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Indole peptidomimetics as thrombin receptor antagonists
    Patent number: 6858577
    Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: February 22, 2005
    Assignees: Ortho-McNeil Pharmaceutical, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
  • Macroheterocylic compounds useful as kinase inhibitors
    Patent number: 6828327
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 7, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Tricyclic benzodiazepines as vasopressin receptor antagonists
    Publication number: 20040242866
    Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Application
    Filed: February 10, 2004
    Publication date: December 2, 2004
    Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews
  • Piperidinyl targeting compounds that selectively bind integrins
    Publication number: 20040224986
    Abstract: The present invention relates to the synthesis and biological application of piperidinoyl carboxylic acid integrin antagonists affinity moiety of IFormula (I): 1
    Type: Application
    Filed: February 18, 2004
    Publication date: November 11, 2004
    Inventors: Bart De Corte, William A. Kinney, Bruce E. Maryanoff, Shyamali Ghosh, Li Liu
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040192718
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 30, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Indoloazepines as vasopressin receptor antagonists
    Patent number: 6765004
    Abstract: The invention is directed to tricyclic indoloazepine compounds useful as vasopressin receptor antagonists, pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions involving increased vascular resistance and cardiac insufficiency which include hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis or water retention in a subject in need thereof.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: July 20, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Michael N. Greco, Leonard R. Hecker, Bruce E. Maryanoff, Jay M. Matthews
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20040138141
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators
    Patent number: 6747127
    Abstract: The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: June 8, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David F. McComsey, Bruce E. Maryanoff, Michael J. Hawkins
  • Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
    Patent number: 6740657
    Abstract: The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: May 25, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Bruce E. Maryanoff, Han-Cheng Zhang, David F. McComsey
  • Piperidinyl compounds that selectively bind integrins
    Publication number: 20040077684
    Abstract: The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder.
    Type: Application
    Filed: August 15, 2003
    Publication date: April 22, 2004
    Inventors: Bart De Corte, William A. Kinney, Bruce E. Maryanoff, Shyamali Ghosh, Li Liu
  • Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators
    Publication number: 20040063903
    Abstract: The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: June 26, 2003
    Publication date: April 1, 2004
    Inventors: David F. McComsey, Bruce E. Maryanoff, Michael J. Hawkins
  • Novel benzimidazolone peptidomimetics as thrombin receptor antagonists
    Publication number: 20040063642
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 17, 2003
    Publication date: April 1, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Tricyclic benzodiazepines as vasopressin receptor antagonists
    Patent number: 6713475
    Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: March 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040059113
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 25, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Bruce R. Conway, Keith Demarest
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Patent number: 6710061
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: March 23, 2004
    Assignee: Ortho-McNeil Pharamceutical, Inc.
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040054180
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 18, 2004
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040006095
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey