Patents by Inventor Bruce E. Maryanoff

Bruce E. Maryanoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel indole peptidomimetics as thrombin receptor antagonists
    Publication number: 20030224999
    Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 31, 2003
    Publication date: December 4, 2003
    Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Publication number: 20030203936
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Application
    Filed: May 16, 2003
    Publication date: October 30, 2003
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Novel indazole peptidomimetics as thrombin receptor antagonists
    Publication number: 20030199455
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 31, 2003
    Publication date: October 23, 2003
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Anjali Pandey, Robert M. Scarborough
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Patent number: 6630505
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: October 7, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Benzimidazolone peptidometics as thrombin receptor antagonist
    Patent number: 6630451
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: October 7, 2003
    Assignee: OrthoMcNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Isonipecotamides for the treatment of integrin-mediated disorders
    Publication number: 20030181440
    Abstract: The invention is directed to novel isonipecotamide derivatives of Formula (I): 1
    Type: Application
    Filed: January 16, 2003
    Publication date: September 25, 2003
    Inventors: Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Publication number: 20030166681
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 4, 2003
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • AMINOPYRROLIDINE SULFONAMIDES AS SERINE PROTEASE INHIBITORS
    Publication number: 20030166680
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 4, 2003
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists
    Publication number: 20030119822
    Abstract: The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders.
    Type: Application
    Filed: October 11, 2002
    Publication date: June 26, 2003
    Inventors: Alexey B. Dyatkin, William J. Hoekstra, Bruce E. Maryanoff
  • Macroheterocylic compounds useful as kinase inhibitors
    Publication number: 20030078280
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 6, 2001
    Publication date: April 24, 2003
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Patent number: 6538017
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: March 25, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Publication number: 20030004186
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Application
    Filed: March 5, 2002
    Publication date: January 2, 2003
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration
    Patent number: 6495523
    Abstract: Anticonvulsant compounds of the general formula I: where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal injury, non-fatal cardiac arrest, or major surgical procedures. Furthermore, pharmaceutical compositions containing a compound of formula I as well as methods for their use are disclosed.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: December 17, 2002
    Assignee: Ortho McNeil-Pharmaceutical, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff, Richard P. Shank
  • Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
    Publication number: 20020160963
    Abstract: The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
    Type: Application
    Filed: January 29, 2002
    Publication date: October 31, 2002
    Inventors: Bruce E. Maryanoff, Han-Cheng Zhang, David F. McComsey
  • Peptidyl heterocyclic ketones useful as tryptase inhibitors
    Patent number: 6469036
    Abstract: The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: October 22, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff, Stephen C. Yabut
  • Tricyclic benzodiazepines as vasopressin receptor antagonists
    Publication number: 20020103373
    Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Application
    Filed: July 24, 2001
    Publication date: August 1, 2002
    Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews
  • Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
    Publication number: 20020091115
    Abstract: The invention is directed to aza-bridged-bicyclic compounds having Formula (I): 1
    Type: Application
    Filed: June 26, 2001
    Publication date: July 11, 2002
    Inventors: Alexey B. Dyatkin, Bruce E. Maryanoff, William J. Hoekstra, Wei He, William A. Kinney
  • Indole and indazole urea-peptoids as thrombin receptor antagonists
    Patent number: 6365617
    Abstract: The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: April 2, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David F. McComsey, William J. Hoekstra, Bruce E. Maryanoff, Han-Cheng Zhang
  • Triazolopyridines for the treatment of thrombosis disorders
    Patent number: 6303625
    Abstract: The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present invention, methods of treating conditions mediated by GPIIb/IIIa (e.g., methods for treating platelet-mediated thrombotic disorders) along with processes for making the compounds and novel intermediates are also disclosed.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: October 16, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Edward C. Lawson, Bruce E. Maryanoff
  • 3-Oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)benzimidazole-5-carboxyl derivatives useful in treating central nervous system disorders
    Patent number: 6218384
    Abstract: A compound of the general formula I; is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: April 17, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Bruce E. Maryanoff, David F. McComsey, Winston Ho