Patents by Inventor Bruce J. Simon

Bruce J. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230005626
    Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
    Type: Application
    Filed: September 13, 2022
    Publication date: January 5, 2023
    Applicant: 07866
    Inventors: Joseph P. Errico, Bruce J. Simon, Peter Staats, Thomas Errico
  • Patent number: 11534600
    Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: December 27, 2022
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11517742
    Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: December 6, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220378359
    Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
    Type: Application
    Filed: July 27, 2022
    Publication date: December 1, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20220379115
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the trigeminal nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through one or more electrodes and the outer skin surface of the forehead of the patient to modulate the nerve within the patient.
    Type: Application
    Filed: August 10, 2022
    Publication date: December 1, 2022
    Applicant: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11511109
    Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 29, 2022
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220347471
    Abstract: Systems and methods are provided for modulating one or more nerves within patients. A method comprises generating a signal comprising an electrical impulse and contacting an interface with an outer skin surface of a patient. The electrical impulse is delivered from one or more electrode(s) through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve sufficiently to treat a medical condition. The one or more electrode(s) are spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
    Type: Application
    Filed: July 6, 2022
    Publication date: November 3, 2022
    Applicant: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220323745
    Abstract: Systems, devices and methods are provided for delivering electrical impulses to the vagus nerve to inhibit the reduction of telomere lengths in cellular DNA, thereby potentially increasing an individual's longevity and/or healthspan. A method comprises positioning a contact surface of a device in contact with an outer skin surface of a patient. An electrical impulse is applied transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol. The stimulation protocol includes at least two doses administered each day for a plurality of day. The doses each have a duration of about 60 seconds to about 5 minutes, preferably about 90 seconds to 3 minutes. The electrical impulse and the stimulation protocol are sufficient to modulate the vagus nerve such that such that the rate of telomere shortening in the patient's cellular DNA is reduced.
    Type: Application
    Filed: April 28, 2022
    Publication date: October 13, 2022
    Inventors: Peter Staats, Bruce J. Simon, Joseph P. Errico
  • Publication number: 20220313986
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session of 2 to 4 times within an hour time period and/or as a single dose from 2 to 5 times during a day.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 6, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 11458297
    Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: October 4, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11458325
    Abstract: Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods include positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: October 4, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle, Steven Mendez
  • Patent number: 11446491
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through one or more electrodes and the outer skin surface of the patient to modulate a nerve within the patient.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: September 20, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11439818
    Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: September 13, 2022
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11432760
    Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: September 6, 2022
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20220273939
    Abstract: Systems and methods for treating diseases and disorders in a patient are provided. A device comprises a stimulator comprising an electrode and an energy source. The energy source is configured to generate an electrical impulse and transmit the electrical impulse to the electrode through an outer skin surface to a vagus nerve of the patient. The device further comprises a sensor for detecting a physiological parameter of a patient's heart and a controller coupled to the stimulator and the sensor and configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. In some aspects, the electrical impulse is sufficient to modulate the vagus nerve to treat a cardiac arrhythmia of the patient.
    Type: Application
    Filed: May 7, 2022
    Publication date: September 1, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220266015
    Abstract: Devices, systems and methods for treating various disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator including an electrode configured to contact an outer skin surface of a patient and an energy source coupled to the housing, The energy source generates an electrical impulse and the stimulator transmits the electrical impulse from the electrode transcutaneously through an outer skin surface of the patient to a selected nerve within the patient. The system further includes an application on a mobile device that receives data from a remote source. The mobile device couples to the stimulator and the application causes the mobile device to transmit the data to the stimulator.
    Type: Application
    Filed: March 14, 2022
    Publication date: August 25, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11406825
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: August 9, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11400288
    Abstract: A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: August 2, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20220233845
    Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve.
    Type: Application
    Filed: April 5, 2022
    Publication date: July 28, 2022
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11389103
    Abstract: Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: July 19, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico