Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a vagus nerve. The system comprises a handheld stimulator including a housing having a contact surface for contacting an outer skin surface of a patient. The housing is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal. An energy source is coupled to the stimulator and the mobile device. The energy source is configured to generate an electric field that transmits an electric current through the contact surface and the outer skin surface to modulate a nerve within the patient and thereby treat a medical condition of the patient.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that applies an electrical impulse transcutaneously through an outer skin surface of the patient. The electrical impulse includes pulses having a frequency of about 1 kHz to about 20 kHz. The device housing may transmit data to or from a patient interface device, such as a mobile phone or computer, relating to the stimulation parameters. The interface device in turn may communicate with a database contained within other computers, via a network or the internet.

Abstract: Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.

Abstract: Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface for contacting an outer skin surface of a patient and a pulse generator coupled to the contact surface. The pulse generator is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The pulse generator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a vagus nerve. The system comprises a handheld stimulator including a housing having a contact surface for contacting an outer skin surface of a patient. The housing is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal. An energy source is coupled to the stimulator and the mobile device. The energy source is configured to generate an electric field that transmits an electric current through the contact surface and the outer skin surface to modulate a nerve within the patient and thereby treat a medical condition of the patient.

Abstract: Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a spinal nerve within the patient such that the patient experiences at least some pain relief. The methods include varying an electric field such that burst periods and constant periods are created. The electric field has a charge that alternates between positive and negative during the burst periods and a charge with a magnitude of zero during the constant periods.

Abstract: Methods and devices for stimulating a nerve in a patient include positioning a device adjacent an outer skin surface of the patient and emitting an electrical field near the vagus nerve within the patient. The electric field is varied to create burst periods and constant periods. The charge of the electric field emitted during the burst periods alternates between positive and negative. The charge of the electric field emitted during the constant periods has a magnitude of zero.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface for contacting an outer skin surface of a patient and a pulse generator coupled to the contact surface. The pulse generator is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The pulse generator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: Devices and methods are provided for treating a patient that include delivering an electrical signal to a target nerve within the patient. The electrical signal has parameters selected to modulate the target nerve for therapeutic purposes to treat a disease or disorder in the patient.

Abstract: Systems and methods for reducing or inhibiting an inflammatory response in a patient include a source of energy and one or more electrodes coupled to the source of energy and positionable near a vagus nerve of the patient to deliver the electrical impulse to the vagus nerve. The electrical impulse is sufficient to either inhibit a release of a pro-inflammatory cytokine, such as TNF-alpha, or increase an anti-inflammatory competence of a cytokine, such as TGF-beta, in the patient, thereby inhibiting the inflammatory response. The electrical impulse may be delivered transcutaneously and non-invasively through an outer skin surface of the patient to the vagus nerve.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts with a frequency of 1 to 100 Hz. Each of the bursts has 2 to 20 pulses with a duration of about 50 microseconds to about 1000 microseconds.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient. The systems and methods of the present invention reduce the expression of inflammatory mediators that are elevated in ARDS and other inflammatory or allergic disorders, thereby ameliorating the overactivity of the immune reaction in patient's suffering from certain disorders, such as the coronavirus. This therapy may include a feedback mechanism to provide potent anti-inflammatory benefits without the negative side effects of conventional immune suppression techniques and drugs, such as steroids and other nebulized drugs.

Abstract: Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods incluce positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The the electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.

Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts of about 2 to about 20 pulses and the pulses oscillate between a positive voltage and a negative voltage within each burst.

Abstract: Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of treating lower urinary tract disorders using energy that is delivered noninvasively by the devices. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In embodiments of the disclosed methods, a posterior tibial nerve of a patient is stimulated non-invasively. Methods are disclosed for selecting protocol parameters for a nerve stimulation session for treating each individual patient, wherein modules of the bladder of the patient are represented as coupled non-linear oscillators.

Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.