Abstract: This document discusses, among other things, systems and methods for managing pain in a patient. A system may include sensors to sense physiological or functional signals, and a pain analyzer that generates a pain score using the sensed physiological or functional signals and a fusion model. The system includes a calibration module that calibrates the fusion model based on measurements from the sensed physiological or functional signals and a reference pain quantification corresponding to multiple pain intensities. A pain score may be generated using the calibrated fusion model. The system can additionally include a neurostimulator that controls the delivery of pain therapy by adjusting one or more stimulation parameters based on the pain score.

Abstract: An application or other non-transitory computer-readable medium for storing instructions is disclosed. The instructions are executed by at least one processing device which is configured to store at least one user preference. The at least one user preference comprises a selection of one or more monitored applications and one or more warning thresholds corresponding to the one or more monitored applications. The one or more warning thresholds comprise a user selected time period. Further, time information associated with a use of the one or more monitored applications, is obtained. The time information is determined according to an accessibility event notifications function, on an operating system of a device. Further, the at least one user preference and the obtained time information are compared to determine whether the one or more warning thresholds have been exceeded. Thereafter, a notification is delivered to the user, upon exceeding the one or more warning thresholds.

Abstract: This document discusses, among other things, systems and methods for managing pain in a subject. A system may include one or more sensors configured to sense from the subject information corresponding to emotional reaction to pain, such as emotional expression. The emotional expression includes facial or vocal expression. A pain analyzer circuit may generate a pain score using signal metrics of facial or vocal expression extracted from the sensed information. The pain score may be output to a user or a process. The system may additionally include a neurostimulator that can adaptively control the delivery of pain therapy by automatically adjusting stimulation parameters based on the pain score.

Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.

Abstract: In response to a user interacting with a tangible peripheral assistant control device (e.g., depressing a button of the device), causing an automated assistant to perform one or more actions. The action(s) performed can be based on input previously provided by the user in configuring the peripheral assistant control device. The action(s) performed in response to interaction with the peripheral assistant control device can vary based on one or more conditions, such as which user is currently active, where the peripheral assistant control device is currently located (which can optionally be inferred based on which of multiple assistant computing devices the button is paired with), and/or the current state of one or more smart devices and/or other devices (e.g., as determined based on a device topology). A utility of the peripheral assistant control device can be automatically extended beyond what was specifically requested by a user during configuration.

Abstract: Sealing in rotary positive displacement machines based on trochoidal geometry that comprise a helical rotor that undergoes planetary motion within a helical stator is described. Seals can be mounted on the rotor, the stator, or both. The rotor can have a hypotrochoidal cross-section, with the corresponding stator cavity profile being the outer envelope of the rotor as it undergoes planetary motion, or the stator cavity can have an epitrochoidal cross-section with the corresponding rotor profile being the inner envelope of the trochoid as it undergoes planetary motion. In some embodiments, the geometry is offset in a manner that provides advantages with respect to sealing in the rotary machine. In multi-stage embodiments, the rotor-stator geometry remains substantially constant or varies along the axis of the rotary machine.

Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.

Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.

Abstract: Nucleobase amino acid polymer compositions and methods for synthesizing nucleobase amino acid polymers and their conversion to nucleic acids are provided. The nucleobase amino acid polymer compositions disclosed herein comprise nucleobase amino acid monomers that comprise a linker and a nucleobase. The methods disclosed herein comprise synthesizing a nucleic acid polymer by providing a mRNA template, at least one ribosome, at least one nucleobase amino acid tRNA and at least one non-nucleobase amino acid tRNA; and adding a polymerase and at least one primer to the nucleobase amino acid polymer.

Abstract: Sealing in rotary positive displacement machines based on trochoidal geometry that comprise a helical rotor that undergoes planetary motion within a helical stator is described. Seals can be mounted on the rotor, the stator, or both. The rotor can have a hypotrochoidal cross-section, with the corresponding stator cavity profile being the outer envelope of the rotor as it undergoes planetary motion, or the stator cavity can have an epitrochoidal cross-section with the corresponding rotor profile being the inner envelope of the trochoid as it undergoes planetary motion. In some embodiments, the geometry is offset in a manner that provides advantages with respect to sealing in the rotary machine. In multi-stage embodiments, the rotor-stator geometry remains substantially constant or varies along the axis of the rotary machine.

Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.

Abstract: A method for evaluating a gastrointestinal tract may include receiving an electrical signal that includes data pertaining to motility in the gastrointestinal tract of a patient and analyzing one or more characteristics of the electrical signal relative to one or more respective thresholds indicative of an occurrence or an imminence of a condition of the gastrointestinal tract.

Abstract: Rotary positive displacement machines based on trochoidal geometry and including a helical rotor that undergoes planetary motion relative to a helical stator can be designed and configured so that the axial load or rotor pressure force is positive, negative, or neutral. In some embodiments, a change in axial load, caused by a change in differential pressure across the machine, can be used to trigger a change in a mechanical configuration of the machine.

Abstract: The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically bind to at least CD3, as well as to methods of making and using these antibodies, activatable antibodies, multispecific antibodies, and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An example of a system for monitoring and treating respiratory distress in a patient may include one or more non-invasive monitoring devices to acquire patient condition signals and a respiratory distress monitoring circuit to monitor a state of the respiratory distress using the patient condition signals. The respiratory distress monitoring circuit may include a signal processing circuit to generate patient condition parameters using the patient condition signals and a respiratory distress analyzer, which may include a parameter analysis circuit and a notification circuit. The parameter analysis circuit may be configured to produce a patient condition metric being a function of the patient condition parameters and to perform prediction and/or detection of an exacerbation of the respiratory distress based on the patient condition metric. The notification circuit may be configured to produce an alert notifying a result of the performance of the prediction and/or detection.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: In response to a user interacting with a tangible peripheral assistant control device (e.g., depressing a button of the device), causing an automated assistant to perform one or more actions. The action(s) performed can be based on input previously provided by the user in configuring the peripheral assistant control device. The action(s) performed in response to interaction with the peripheral assistant control device can vary based on one or more conditions, such as which user is currently active, where the peripheral assistant control device is currently located (which can optionally be inferred based on which of multiple assistant computing devices the button is paired with), and/or the current state of one or more smart devices and/or other devices (e.g., as determined based on a device topology). A utility of the peripheral assistant control device can be automatically extended beyond what was specifically requested by a user during configuration.

Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.

Abstract: A method for evaluating a gastrointestinal tract may include receiving an electrical signal that includes data pertaining to motility in the gastrointestinal tract of a patient and analyzing one or more characteristics of the electrical signal relative to one or more respective thresholds indicative of an occurrence or an imminence of a condition of the gastrointestinal tract.