Abstract: An example of a system for providing a patient with pain management includes a pain monitoring circuit. The pain monitoring circuit may include parameter analyzer circuitry and pain score generator circuitry. The parameter analyzer circuitry may be configured to receive and analyze one or more timing parameters and one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient. The one or more timing parameters are indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS. The pain score generator circuitry may be configured to compute a pain score using an outcome of the analysis. The pain score is a function of the BRS during the time intervals and indicative of a degree of pain of the patient.

Abstract: A system may include an implantable structure with a plurality of electrodes attached thereto, where the implantable structure is configured to be implanted proximate to a nerve that innervates and is proximate to an organ involved with glucose control. The system may further include a controller configured for use to control which of the plurality of electrodes are modulation electrodes and which of the plurality of electrodes are sense electrodes, a modulation energy generator configured to deliver modulation energy using one or more of the modulation electrodes, and a nerve traffic sensor configured to sense nerve traffic in the nerve using one or more of the sense electrodes. The controller may be configured to determine if the delivered modulation energy captures the nerves based on the sensed neural activity.

Abstract: Rotary positive displacement machines with trochoidal geometry that comprise a helical rotor that undergoes planetary motion within a helical stator are described. The rotor can have a hypotrochoidal cross-section, with the corresponding stator cavity profile being the outer envelope of the rotor as it undergoes planetary motion, or the stator cavity can have an epitrochoidal cross-section with the corresponding rotor profile being the inner envelope of the trochoid as it undergoes planetary motion. In some multi-stage embodiments, the rotor-stator geometry remains substantially constant along the axis of the rotary machine. In other multi-stage embodiments, the rotor-stator geometry varies along the axis of the rotary machine.

Abstract: Computer vision and image characteristic search is described. The described system leverages visual search techniques by determining visual characteristics of objects depicted in images and comparing the determined characteristics to visual characteristics of other images, e.g., to identify similar visual characteristics in the other images. In some aspects, the described system performs searches that leverage a digital image as part of a search query to locate digital content of interest. In some aspects, the described system surfaces multiple user interface instrumentalities that include images of patterns, textures, or materials and that are selectable to initiate a visual search of digital content having a similar pattern, texture, or material. The described aspects also include pattern-based authentication in which the system determines authenticity of an item in an image based on a similarity of its visual characteristics to visual characteristics of known authentic items.

Abstract: The present disclosure, in its various aspects, is directed to expandable guide devices, implementation methods, and related delivery systems. Embodiments according to the present disclosure, including as described herein, may increase the effectiveness and efficiency of endoscopy procedures. In one example, an expandable guide device is configured to receive an instrument through an instrument lumen of the device, wherein the device comprises first and second bodies, with first and second expandable members disposed about the first and second bodies.

Abstract: Systems and methods for tracking dental aligner production and manufacture for a plurality of patients are disclosed herein. Exemplary methods include displaying a graphical user interface for the tracking dental aligner production and manufacture for the plurality of patients comprising: a first row of cells containing a first subject heading displaying a scan status, the scan status being a status of the receiving the intra-oral scan; a second row of cells containing a second subject heading displaying a treatment plan status, the treatment plan status being a status of the receiving a treatment plan including the desired teeth positions of the patient based on the intra-oral scan; and a third row of cells containing a third subject heading displaying a printing status, the printing status being a status of the printing, using a three-dimensional (3D) printer, the series of dental models matching the series of modified teeth positions.

Abstract: A custom cryptographic token and smart contract that is configured to exist in one of two groups and is issued by the same bank or depository institution that also collects corresponding fiat currency deposits. The two groups are a circulation group and a non-circulation group. The non-circulation group is not associated with any given user, but rather an issuing entity. Custom cryptographic tokens residing in the circulation group are associated with a user and are traded according to smart contract protocol.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: In response to a user interacting with a tangible peripheral assistant control device (e.g., depressing a button of the device), causing an automated assistant to perform one or more actions. The action(s) performed can be based on input previously provided by the user in configuring the peripheral assistant control device. The action(s) performed in response to interaction with the peripheral assistant control device can vary based on one or more conditions, such as which user is currently active, where the peripheral assistant control device is currently located (which can optionally be inferred based on which of multiple assistant computing devices the button is paired with), and/or the current state of one or more smart devices and/or other devices (e.g., as determined based on a device topology). A utility of the peripheral assistant control device can be automatically extended beyond what was specifically requested by a user during configuration.

Abstract: Computer vision and image characteristic search is described. The described system leverages visual search techniques by determining visual characteristics of objects depicted in images and comparing the determined characteristics to visual characteristics of other images, e.g., to identify similar visual characteristics in the other images. In some aspects, the described system performs searches that leverage a digital image as part of a search query to locate digital content of interest. In some aspects, the described system surfaces multiple user interface instrumentalities that include images of patterns, textures, or materials and that are selectable to initiate a visual search of digital content having a similar pattern, texture, or material. The described aspects also include pattern-based authentication in which the system determines authenticity of an item in an image based on a similarity of its visual characteristics to visual characteristics of known authentic items.

Abstract: In response to a user interacting with a tangible peripheral assistant control device (e.g., depressing a button of the device), causing an automated assistant to perform one or more actions. The action(s) performed can be based on input previously provided by the user in configuring the peripheral assistant control device. The action(s) performed in response to interaction with the peripheral assistant control device can vary based on one or more conditions, such as which user is currently active, where the peripheral assistant control device is currently located (which can optionally be inferred based on which of multiple assistant computing devices the button is paired with), and/or the current state of one or more smart devices and/or other devices (e.g., as determined based on a device topology). A utility of the peripheral assistant control device can be automatically extended beyond what was specifically requested by a user during configuration.

Abstract: A custom cryptographic token and smart contract that is configured to exist in one of two groups and is issued by the same bank or depository institution that also collects corresponding fiat currency deposits. The two groups are a circulation group and a non-circulation group. The non-circulation group is not associated with any given user, but rather an issuing entity. Custom cryptographic tokens residing in the circulation group are associated with a user and are traded according to smart contract protocol.

Abstract: The bezel assembly for data reception, for use with a bill validator in a financial transactional device, includes a bezel housing and a data reception assembly. The bezel housing includes a customer-facing front portion and a back plate connectable to the bill validator that is mounted within the transactional device cabinet. The front portion includes an insertion/dispensing slot for receiving currency and a projecting protrusion forward of the casing. The forward-extending protrusion accommodates at least a portion of the data reception assembly. The bezel assembly can include a wireless communication function that is communicably connectable with a mobile device via a wireless communication method, a manual entry function, a biometric reader, one or more cameras for scanning and decrypting 2D barcodes and the like, thus enhancing the overall functionality of the financial transactional device.

Abstract: An example of a system includes a blood pressure modulation device and a controller. The blood pressure modulation device may be configured to deliver a therapy to chronically maintain blood pressure within a prescribed range. The blood pressure modulation device may include a neuromodulator configured to deliver neuromodulation energy to neural tissue in a spinal cord or near the spinal cord using a first parameter set. The controller may include analyzer circuitry configured to determine an actual or anticipated blood pressure demand event indicated for a blood pressure change, and therapy parameter adjuster circuitry configured to respond to the actual or anticipated blood pressure demand event by delivering neuromodulation energy using a second parameter set to change the blood pressure.

Abstract: Computer vision for unsuccessful queries and iterative search is described. The described system leverages visual search techniques by determining visual characteristics of objects depicted in images and describing them, e.g., using feature vectors. In some aspects, these visual characteristics are determined for search queries that are identified as not being successful. Aggregated information describing visual characteristics of images of unsuccessful search queries is used to determine common visual characteristics and objects depicted in those images. This information can be used to inform other users about unmet needs of searching users. In some aspects, these visual characteristics are used in connection with iterative image searches where users select an initial query image and then the search results are iteratively refined.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: A 3D objects training dataset is augmented by accessing a 3D point cloud representation of an object and by applying an augmentation routine on the point cloud to generate an augmented point cloud. The augmentation routine comprises randomly selecting an execution order of at least one of (i) adding a noise to the point cloud, (ii) applying a geometric transformation on the point cloud and (iii) applying a degradation on the point cloud. The randomly selected execution order of these operations on the point cloud is applied, and the augmented point cloud is added to the objects training dataset. A machine learning algorithm (MLA) is trained by inputting the 3D point cloud representation to generate an output, comparing the output with an expected label associated with the point cloud representation to determine a measure of error on the output, and iteratively adjusting various weights associated with nodes of the MLA.

Abstract: This document discusses, among other things, systems and methods for managing pain in a patient. A system may include sensors to sense physiological or functional signals, and a pain analyzer that generates a pain score using the sensed physiological or functional signals and a fusion model. The system includes a calibration module that calibrates the fusion model based on measurements from the sensed physiological or functional signals and a reference pain quantification corresponding to multiple pain intensities. A pain score may be generated using the calibrated fusion model. The system can additionally include a neurostimulator that controls the delivery of pain therapy by adjusting one or more stimulation parameters based on the pain score.

Abstract: The invention relates generally to multispecific antibodies and to multispecific activatable antibodies that specifically bind to two or more different antigens or epitopes, as well as to methods of making and using these multispecific antibodies and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Rotary positive displacement machines based on trochoidal geometry that includes a helical rotor that undergoes planetary motion relative to a helical stator are described. The rotor can have a hypotrochoidal-based cross-sectional shape, with the corresponding stator cavity cross-sectional shape being the outer envelope of the rotor cross-sectional shape as it undergoes planetary motion, or the stator cavity can have an epitrochoidal-based cross-sectional shape with the corresponding rotor cross-sectional shape being the inner envelope of the stator cross-sectional shape as it undergoes planetary motion. Such machines can be configured so that the stator axis is spaced from the rotor axis, the rotor is configured to spin about its axis and the stator is configured to spin about its axis, and/or the rotor and the stator are held at a fixed eccentricity so that the rotor undergoes planetary motion relative to the stator, but does not orbit.