Abstract: The invention concerns a bicyclic derivative of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl; R.sup.1 if (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.1 --X--A.sup.2 ---, wherein each of A.sup.1 and A.sup.2 is (1-4C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino.The invention also concerns processes for the manufacture of a bicyclic derivative of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said bicyclic derivatives. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

Abstract: cDNA clones coding for the chicken Cysteine proteinase inhibitor cystatin were found and isolated using for example a synthetic oligonucleotide probe corresponding to amino acids 81-90 of the cystatin sequence. This was used to screen a lambda gt 11 chicken oviduct cDNA library. A full length cystatin cDNA was also isolated.

Abstract: Cephalosporin compounds having a 3-position substituent of the formula (I) are described:--CH.sub.2 --Y--Q (I)wherein Y is a bond or a linking group --NR.sup.4 --Y'--, --O--Y'--, 13 S--Y'-- wherein R.sup.4 is hydrogen, various optionally substituted alkyl groups, alkenyl, alkanoyl or alkanesulphonyl, and Y' is a bond or various optionally substituted alkylene groups; and Q is a benzene ring (optionally fused to a further benzene ring so forming a naphthyl group or optionally fused to a 5 or 6 membered heterocyclic aromatic group containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur), said benzene ring being substituted by groups R.sup.1 and R.sup.2 which are ortho with respect to one another, wherein R.sup.1 is hydroxy or an in vivo hydrolyzable ester thereof and R.sup.2 is hydroxy, and in vivo hydrolyzable ester thereof, carboxy, sulpho, hydroxymethyl, methanesulphonamido or ureido; or Q is a group of the formula (II) or (III): ##STR1## wherein M is oxygen or a group NR.sup.3 wherein R.

Abstract: The invention concerns a thiazole of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted aryl of up to 10 carbon atoms;A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;X is oxy, thio, sulphinyl, sulphonyl or imino;Ar.sup.2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;R.sup.2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl;Q is optionally substituted thiazolyl;or a pharmaceutically-acceptable salt thereof.The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole.

Abstract: Cephalosporin compounds having a 3-position substituent of the formula (I) are described:--CH.sub.2 --Y--Q (I)wherein Y is a linking group --NR.sup.4 CO--Y'--, --NR.sup.4 SO.sub.2 --Y'--, --OCO--Y;-- or --SCO--Y'-- wherein R.sup.4 is hydrogen, various optionally substituted alkyl groups or alkenyl and Y' is a bond or various optionally substituted alkylene or alkenylene groups; and Q is a benzene ring (optionally fused to a further benzene ring so forming a naphthyl group or optionally fused to a 5 or 6 membered heterocyclic aromatic group containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur), said benzene ring (or in the case of naphthyl either benzene ring) being substituted by groups R.sup.1 and R.sup.2 which are ortho with respect to one another, wherein R.sup.1 is hydroxy or an in vivo hydrolyzable ester thereof and R.sup.

Abstract: Cephalosporins having a 3-position substituent of the formula: ##STR1## are described, wherein R.sup.5 is hydrogen, alkenyl, alkyl or substituted alkyl, Q is a mono- or bicyclic heterocyclic ring, variously substituted, Y is variously substituted alkylene, Y' represents various linking groups, m and n are independently zero or one, and P is a benzene ring with two ortho groups, one of which is hydroxy or an in-vivo hydrolysable ester thereof and the other is hydroxy, an in vivo hydrolysable ester thereof, carboxy, sulpho, hydroxymethyl, --NHSO.sub.2 CH.sub.3 or --NHCONH.sub.2 ; or P is a particularly substituted pyridone or pyranone. The use of such compounds as antibacterial agents is described, as are processes for their preparation.

Abstract: Cephalosporin compounds having as a 3-substituent the group: ##STR1## wherein Y represents a bond, optionally substituted alkylene or --CH.sub.2 CH.sub.2 NHCO--, P is a benzene ring substituted by groups W and Z ortho with respect to one another wherein W is hydroxy or an in vivo hydrolyzable ester thereof, Z is hydroxy, an in vivo hydrolyzable ester thereof, carboxy, sulpho, hydroxymethyl, --NHSO.sub.2 CH.sub.3 or NHCONH.sub.2, Q is a mono- or bicyclic ring system substituted by R.sup.7 wherein R.sup.7 is hydrogen or a range of groups and ring Q is optionally further substituted; are described as antibacterial agents. Processes for their preparation and their methods of use are described.

Abstract: An analogue current memory has a current input (1) which is connected to the input branch of a first current mirror circuit formed by two transistors (T4 and T8). The input and output branches of the first current mirror are isolated by a first switch (S1) which is controlled by a clock signal .phi.A. The output branch of the first current mirror is connected to the input branch of a second current mirror formed by two transistors (T9 and T12). The input and output branches of the second current mirror are isolated by a second switch (S2) which is controlled by a clock signal .phi.B which does not overlap the clock signal .phi.A. The first switch is closed during the first half of the sample period and the second switch is closed during the second half. A current fed to input 1 is mirrored by the transistor T8 while the first switch (S1) is closed and a first capacitor (CA) charges to the gate/source voltage of transistor T8.

Abstract: A sampled analog electrical signal in the form of sample currents is processed by combining the input sample current in one sample period with sample currents derived from input sample currents in preceding sample periods. The signal processing is performed by scaling, adding, subtracting and storing sample currents. A circuit arrangement for carrying out the signal processing may be constructed from current mirror circuits and a current memory which is capable of reproducing at its output in one sample period the current applied to its input in a previous sample period.

Abstract: A shoe ground strap which has a static dissipative exposed surface and offers protection against static charges building on the wearer and offers protection against electrical hazards if contacting a source of electrical power. The strap comprises a band comprising a conductive metal ribbon, a static dissipative material and an adhesive layer to aid in holding the strap to the shoe, with at least the surface and the two edges of the band covered by said static dissipative material to expose only the static dissipative material.

Abstract: A drop out trigger captures waveform data when a normally continuous input signal is disrupted or interrupted. In the preferred embodiment, a conventional trigger detects a parameter periodically satisfied by the continuous signal and resets a timer whenever a trigger event occurs. The alarm count of the timer is set for an interval slightly larger than the periodic interval. If the timer reaches the alarm count, a measurement signal is generated.

Abstract: To provide security of attachment, between one container and another similar container adapted to be stacked on the top of the first container, each container has a keeper slot in one or more of its side walls adjacent the container floor and a spring leaf at the top of the container which may be bowed into either one of two stable positions. In one of these positions the leaf of one container registers with and locks within the keeper slot of a second similar container poised above the first container, and when the leaf is in the other of its stable positions it is disengaged from the keeper slot.

Abstract: A power operated machine or press which utilizes the principle of the "Archimedian-Screw," in association with screening means and other pressure exerting means to partially separate the solid and liquid elements of compressible animal or vegetable tissue and to control the moisture content of the resultant product.