Abstract: The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO.

Abstract: Described herein are DNA-editing complexes, particularly DNA-editing complexes that specifically alter a single base pair in target DNA sequence as well as methods of making and using these DNA-editing complexes.

Abstract: Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.

Abstract: A surgical instrument includes a body, a shaft assembly, a stapling head assembly, an anvil, an anvil adjustment assembly, a trigger, and a lockout assembly. The stapling head assembly is operable to drive an annular array of staples. The anvil is configured to couple with the stapling head assembly. The anvil adjustment assembly includes a translating member, which translates relative to the body to thereby adjust the longitudinal position of the anvil relative to the stapling head assembly. The trigger is operable to actuate the stapling head assembly. The lockout assembly includes an electrically powered braking feature. A method of operating the surgical instrument includes providing the lockout assembly in a first state to permit translation of the translating member. The translating member is then translated. The lockout assembly is then transitioned to a second state to prevent further translation of the translating member.

Abstract: A multi-functional, portable device for use in situations where electricity is not available or convenient is disclosed. A portable safety device includes a power charger and air compressor that may safely jump start a vehicle and recharge portable electronic devices, such as phones and laptop computers, as well as inflate vehicle tires or other inflatable objects, when a standard external power source is not convenient. It may also be used for providing an emergency light source.

Abstract: Nitric oxide (NO) generating compositions can include a nitrite component, an acidifying component, and a support material configured to carry one of the nitrite component and the acidifying agent. In some examples, the support material can minimize NO generation prior to addition of an activating amount of a suitable solvent.

Abstract: A surgical circular stapler has a handle assembly, a shaft, a stapling assembly, and a firing assembly. The shaft extends distally from the handle assembly. The stapling assembly is secured to a distal end of the shaft. Longitudinal translation of the firing assembly causes the stapling assembly to drive a plurality of staples in a circular array to secure two lumens of tissue together. The stapling assembly may further drive a blade to sever any excess tissue interior of the circular array of staples. The stapler further includes a lockout assembly configured to control firing of the stapling assembly. The lockout assembly may include one or more switches, the actuation of which is configured to prevent or permit firing of the stapling assembly. The lockout assembly may additionally or alternatively include one or more mechanical lockout features configured to control firing of the stapling assembly.

Abstract: A sensor licensing system for an intraoral sensor includes an on/off mechanism, a driver, and a sensor. The on/off mechanism is coupled to the intraoral sensor and has an encrypted licensing code so that the on/off mechanism turns on and off the intraoral sensor. The driver processes the encrypted license code stored in the sensor memory and determines if license code is expired based on the computer clock, exposure counter or other desired limits. The sensor periodically checks an online server for an updated encrypted license code and stores new license code in sensor memory. The updated license code is created and stored on the server when a new periodic subscription payment is made. The sensor periodically checks and downloads any updated license code. Failure to make a payment will result in no encrypted license code update being created and eventual expiration of the old, encrypted license code.

Abstract: An apparatus includes a body, a shaft assembly, a stapling head assembly, and an anvil. The stapling head assembly includes an annular deck member, a plurality of staples, and a driver. The deck member includes a deck surface that has a curved profile defined by a curve extending from the inner diameter of the deck member to the outer diameter of the deck member. The deck member further includes an outer array of staple openings and an inner array of staple openings. The driver is operable to drive the staples through the staple openings. The anvil is operable to compress tissue against the first deck surface.

Abstract: A solid-state circuit breaker (SSCB) with self-diagnostic, self-maintenance, and self-protection capabilities includes: a power semiconductor device; an air gap disconnect unit connected in series with the power semiconductor device; a sense and drive circuit that switches the power semiconductor device OFF upon detecting a short circuit or overload of unacceptably long duration; and a microcontroller unit (MCU) that triggers the air gap disconnect unit to form an air gap and galvanically isolate an attached load, after the sense and drive circuit switches the power semiconductor device OFF. The MCU is further configured to monitor the operability of the air gap disconnect unit, the power semiconductor device, and other critical components of the SSCB and, when applicable, take corrective actions to prevent the SSCB and the connected load from being damaged or destroyed and/or to protect persons and the environment from being exposed to hazardous electrical conditions.

Abstract: A bottom hole assembly has a tubular component with an axis, a first axial end, a second axial end and a poppet valve assembly mounted in the second axial end. An orifice retainer is mounted inside the tubular component adjacent the first axial end. The orifice retainer has a retainer first axial end, a retainer second axial end opposite the retainer first axial end and an orifice pocket adjacent the retainer second axial end. The orifice retainer is installed in and can be removed from the first axial end of the tubular component, opposite the poppet valve assembly. In addition, an orifice is mounted in the orifice pocket of the orifice retainer. The orifice operates in conjunction with the poppet valve assembly.

Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: Compositions and methods of treating conditions in a subject that are responsive to nitric oxide (NO) treatment are disclosed and described. Such compositions can include a combination of a nitric oxide releasing compound, an acidifying agent, and a carrier in amounts that release from about 1 ppm*min/mL to about 500 ppm*min/mL NO based on 1 mL of the composition when measured by releasing NO from the composition for a period of 30 minutes into a flow of substantially inert carrier gas at a flow rate of 1 liter per minute and a pressure of 1 atmosphere, coupled to a chemiluminescence detector.

Abstract: A surgical circular stapler has a handle assembly, a shaft, a stapling assembly, and a firing assembly. The shaft extends distally from the handle assembly. The stapling assembly is secured to a distal end of the shaft. Longitudinal translation of the firing assembly causes the stapling assembly to drive a plurality of staples in a circular array to secure two lumens of tissue together. The stapling assembly may further drive a blade to sever any excess tissue interior of the circular array of staples. The stapler further includes a lockout assembly configured to control firing of the stapling assembly. The lockout assembly may include one or more switches, the actuation of which is configured to prevent or permit firing of the stapling assembly. The lockout assembly may additionally or alternatively include one or more mechanical lockout features configured to control firing of the stapling assembly.

Abstract: A method of operating a dual bidirectional input to single bidirectional output transmission is disclosed. The method includes providing said transmission. The method includes activating a computer controller capable of receiving torque data signals from a first bidirectional torque input, a second bidirectional torque input, and a single bidirectional torque output. The method includes determining torque input from said first and second bidirectional torque input, and determining whether to transmit torque to said single bidirectional torque output. In cases where it is so determined, the method involves transmitting torque to said single bidirectional torque output.

Abstract: A water treatment system, a water treatment monitoring and/or control system, and a method of monitoring and/or controlling treatment of water are disclosed. The water treatment system generally includes a water pump configured to supply water from a water source to an intake pipe, a chlorine source pump configured to supply a chlorine source from a storage vessel to a chlorine source feed line, a water flow and/or pressure switch configured to detect a positive water flow and/or pressure in the intake pipe, a chlorine flow monitor, and logic or circuitry configured to notify a user and optionally automatically disable or turn off the water pump when (1) the water flow and/or pressure switch detects the positive water flow and/or pressure in the intake pipe and (2) the chlorine source flow monitor detects either that (i) the chlorine source pump is not primed or (ii) there is no flow in the chlorine source feed line.

Abstract: A conversion ring for a portable fire pit allows the portable fire pit to be used within a block fire pit ring. If desired, the owner can remove the fire pit from the conversion ring and the block ring and use it in different locations. The conversion ring and the fire pit can lock together to limit rotational movement after installation. The conversion ring includes locking fingers that cooperate with elements of the fire pit. In one configuration, the locking fingers of the conversion ring cooperate with the legs of the fire pit when the fire pit is installed through the conversion ring.

Abstract: Polyol premixes and thermally insulating rigid polyurethane foams, such as those that can be used as a thermal insulation medium in the construction of refrigerated storage devices, are disclosed. A polymer polyol having a OH number of greater than 260 mg KOH/g is utilized. The resulting polyurethane foams can exhibit improved thermal insulation properties without sacrificing other important physical and processing properties.

Abstract: A grasping tool (10) has a pair of elongate arms (20) attached via a hinge element (26). The elongate arms (20) provide gripping surfaces (28) for grasping an item therebetween. A finger engagement element (30) extends from each of the elongate arms, (20) spaced a distance from the proximal end (22). Each elongate arm (20) is generally disposed on a first axis, and each finger engagement element (30) is disposed around a second axis, such that the second axis is approximately parallel to and located below the first axis, such that the first and second axes are spaced a distance such that the pair of elongate arms (20) are positioned above the fingers of the user when the user's fingers are positioned through the finger engagement elements (30).

Abstract: A receiving and disbursement system is provided for the receipt of items from fulfillment centers, retail locations, or homes to a designated location, securing the delivered items from theft, or inserting the delivered items directly into a building or building automation system. The receiving and disbursement system is further able to reverse the process in order to automatically retrieve items back from the delivery location to return items to retail locations, homes, businesses, fulfillment or recycling centers for delivery, re-filling, recycling and/or disposal. A system of delivery vehicle interfaces, delivery containers, item trays, and docking stations to facilitate the movement of items from one location to another location and back to the same or other designated location. Locations may include industrial, agricultural, business, government, waste disposal, homes, garages, carports, barns, greenhouses, or inside a home.