Abstract: An apparatus is described. The apparatus includes a rack shelf back interface. The rack shelf back interface has first and second flanges to mount to a rack’s rear facing rack mounts. The rack shelf back interface has a power connector610 on an inside of a back face of the rack shelf interface, the power connector to mate with a corresponding power connector on an electronic system that is to be installed in the rack shelf. The rack shelf back interface has an alignment feature on the inside of the back face of the rack shelf interface to ensure that the power connector properly mates with the corresponding power connector.

Abstract: A fenestration assembly includes a sash, a frame surrounding the sash, and at least one screen assembly mounted in at least one of: the top portion and the bottom portion. The frame includes a top portion, a bottom portion, and two jambs forming first slots extending lengthwise along at least a portion of the jamb. The first slots each include a screen edge retention feature. The screen assembly includes a roller assembly substantially hidden from view, a screen material attached to the roller assembly, and a plurality of raised features. Edges of the screen material extend into the first slots. The raised features are attached to each of the edges of the screen material. The raised features are configured to engage the screen edge retention features and retain each of the edges of the screen material at least partially within the first slot of each of the two jambs.

Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

Abstract: A grasping tool (10) has a pair of elongate arms (20) attached via a hinge element (26). The elongate arms (20) provide gripping surfaces (28) for grasping an item therebetween. A finger engagement element (30) extends from each of the elongate arms, (20) spaced a distance from the proximal end (22). Each elongate arm (20) is generally disposed on a first axis, and each finger engagement element (30) is disposed around a second axis, such that the second axis is approximately parallel to and located below the first axis, such that the first and second axes are spaced a distance such that the pair of elongate arms (20) are positioned above the fingers of the user when the user's fingers are positioned through the finger engagement elements (30).

Abstract: Provided herein, inter alia, are fusion DNA constructs comprising improved protease recognition sequences for expressing and purifying one or more polypeptides of interest as well as methods for producing one or more polypeptides of interest in a recombinant host cell.

Abstract: Systems and methods are described for modifying input and output (I/O) to an object storage service by implementing any combination of and any number of owner-specified functions and native functions. A function can implement a data manipulation. The functions can be applied prior to implementing a request method (e.g., GET, PUT, LIST, etc.) specified within the I/O request, such that the data to which the method is applied may not match the object specified within the request. For example, a user may request to obtain a data set. The data set may be passed to a native function that filters sensitive data to the data set, the output of the native function may be passed to an owner-specified function that redacts data from the filtered data set, and the request method may then be applied to the output of the owner-specified function.

Abstract: Systems and methods are described that provide a dynamic reporting functionality that can identify important information and dynamically present a report about the important information that highlights important findings to the user. The described systems and methods are generally described in the field of diabetes management, but are applicable to other medical reports as well. In one implementation, the dynamic reports are based on available data and devices. For example, useless sections of the report, such as those with no populated data, may be removed, minimized in importance, assigned a lower priority, or the like.

Abstract: A surgical instrument includes an end effector, a shaft assembly, and a torque wrench integrally connected with the shaft assembly. The shaft assembly has an acoustic waveguide extending therethrough and the end effector projects distally from the shaft assembly. The acoustic waveguide has a proximal end portion configured to rotatably couple with an ultrasonic transducer assembly. The torque wrench is configured to transmit torque applied to the acoustic waveguide up to a predetermined torque. A portion of the torque wrench is configured to deflect upon receipt of torque greater than the predetermined torque. Accordingly, the portion of the torque wrench slips relative to the acoustic waveguide for limiting coupling of the acoustic waveguide to the ultrasonic transducer assembly to the predetermined torque.

Abstract: A fenestration assembly includes a sash, a frame surrounding the sash, and at least one screen assembly mounted in at least one of: the top portion and the bottom portion. The frame includes a top portion, a bottom portion, and two jambs forming first slots extending lengthwise along at least a portion of the jamb. The first slots each include a screen edge retention feature. The screen assembly includes a roller assembly substantially hidden from view, a screen material attached to the roller assembly, and a plurality of raised features. Edges of the screen material extend into the first slots. The raised features are attached to each of the edges of the screen material. The raised features are configured to engage the screen edge retention features and retain each of the edges of the screen material at least partially within the first slot of each of the two jambs.

Abstract: Methods and devices for controlling motorized surgical devices are provided. In general, the methods and devices can allow a surgical device to grasp and cut tissue. In some embodiments, the device can include at least one sensor and a motor, and an output of the motor can be configured to be adjusted based at least in part on an output from the at least one sensor. The output of the motor can be configured to provide power for translation of a cutting element along an end effector of the device. Adjusting the motor's output can cause the cutting element to translate through the end effector at different speeds, thereby allowing the cutting element to cut through tissue being grasped by the end effector at different speeds.

Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.

Abstract: Provided herein are compositions, methods, and kits for detecting the presence of and/or identifying fastidious microorganisms, such as Bartonella spp., Borrelia spp., Anaplasma spp., Ehrlichia spp., Babesia/Theileria spp., Rickettsia spp., and/or Mycoplasma spp., in a sample. The compositions, methods and kits of the inventive concept include use of droplet digital PCR (ddPCR) assays for the detection and quantitation of the fastidious microorganisms.

Abstract: An apparatus comprises a body assembly, a shaft, an acoustic waveguide, an articulation section, an end effector, and an articulation drive assembly. The shaft extends distally from the body assembly and defines a longitudinal axis. The acoustic waveguide comprises a flexible portion. The articulation section is coupled with the shaft. A portion of the articulation section encompasses the flexible portion of the waveguide. The articulation section comprises a plurality of body portions aligned along the longitudinal axis and a flexible locking member. The flexible locking member is operable to secure the body portions in relation to each other and in relation to the shaft. The end effector comprises an ultrasonic blade in acoustic communication with the waveguide. The articulation drive assembly is operable to drive articulation of the articulation section to thereby deflect the end effector from the longitudinal axis.

Abstract: A workstation having a pair of posts on either side of a clamping plate where a donor bone may be placed on sequentially cut in three separate cutting paths. Cutting gates are attached to the posts and used to provide cutting paths that can be precisely oriented with respect to the meniscus of the donor bone part using visual alignment without any manual measurements. The graft is affixed to a machining clamp and shaved to appropriately shape the sides and form a radius on the bottom of the graft. A tibia is then prepared by using a drill guide to form a pilot hole and then to drill out a large hole for the graft. The drilled hole is expanded and shaped using a rod guide and chisel and then a rasp. The shaped graft may then be implanted into the shaped hole and sutured in place.

Abstract: A pressure reducer for a self-contained breathing apparatus (SCBA) is provided. The pressure reducer includes a body including an outer surface. The pressure reducer further includes a valve unit configured to receive a breathable gas from a high-pressure tank at a tank pressure and to deliver the breathable gas at an outlet pressure lower than the tank pressure. The pressure reducer further includes a plurality of vent holes extending from the outer surface. The plurality of vent holes is configured to vent a gas from an interior of the body. The pressure reducer further includes a cover removably disposed on the outer surface and enclosing the plurality of vent holes. The cover includes a fluid passage disposed in fluid communication with the plurality of vent holes. The fluid passage is configured to receive the gas from the plurality of vent holes and discharge the gas externally of the cover.

Abstract: A knotless suture anchor assembly for engaging a bone tunnel and holding suture therein to knotlessly secure said suture to soft tissue including an elongated generally cylindrical hollow outer member having an axial lumen, an outer surface with projections for engaging the wall of the bone tunnel, a distal end and a proximal end; and an elongated, generally cylindrical inner member having an axis, a proximal end and a distal end, the distal end having a transverse passage for receiving suture therethrough, the transverse passage having a proximal and distal end and adapted to receive a plurality of sutures in said eyelet, the inner member adapted to move coaxially relative to the outer member between a distal, suture-unlocked position and a proximal, suture-locked position.

Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.