Abstract: In accordance with certain embodiments of the present disclosure, a protein arginine methyltransferase inhibitor is provided. The inhibitor comprises an amino acid peptide joined to a chloroacetamidine warhead.

Abstract: A loop hanger, such as for supporting fire sprinkler pipe, contains an integral fold-over washer with an annular stiffening rib, the benefits of which are to minimize deflection of the horizontal ears of the hanger under an applied load and offer simplified installation by eliminating the need for additional flat washers.

Abstract: A sway brace fitting clamp is used for lateral bracing of sprinkler or other types of pipe (designated the service pipe) to a structure, to prevent movement of the service pipe perpendicular to the axis of the pipe relative to the structure to which it is attached. The sway brace fitting clamp includes a U-bolt which fits around the service pipe, and a pair of hooks that are coupled to straight ends of the U-bolt, for hooking the sway brace pipe. A pair of nuts engages threaded portions of the U-bolt ends. The nuts may be tightened to pull the sway brace pipe into contact with the service pipe, firmly clamping the sway brace pipe and the service pipe together.

Abstract: A structural attachment fitting for bracing includes a clamp, and a bracket pivotally coupled to the clamp. The structural attachment fitting is part of a sway brace assembly for providing sway bracing for a conduit, pipe, or other system. The clamp is a generally C-shape clamp having a slot for receiving different types of sway braces, such as pipe, angle, or strut. The slot has multiple sections or parts configured to receive different thicknesses of material. A lower leg of the clamp may have a rounded top surface that better engages a pipe used as a sway brace. A set screw of the clamp is tightened to presses the sway brace against a step on the lower leg of the clamp. The set screw is angled toward a closed end of the slot. The pressing of the set screw tip against the sway brace deforms the sway brace material.

Abstract: An I-beam clamp, used for engaging the bottom flange of an I-beam or bar joist, includes a pair of threaded rods and a pair of brackets that can be moved relative to each other along the threaded rods. One of the brackets, a clamp bracket, has a set screw configured to engage a top surface of the I-beam flange, to hold the clamp in place once it is installed on the I-beam. The other of the brackets, a nut bracket, has half-threaded portions for selectively engaging the threaded rods, to hold the nut bracket in place relative to the threaded rods, and to disengage from the threaded rods, in order to allow positioning of the nut bracket along the threaded rods. The nut bracket may include a spring clip or other device to provide force to bias into engagement the threaded rods with the half-threaded portions.

Abstract: A clamp for engaging a structure flange includes a clamp body having a slot between a pair of body sections, a spring clip on the clamp body that extends into the slot, and a pair of screws threadedly engaged with the clamp body. The spring clip holds a structure flange in place when the clamp is placed on a structure flange, with the flange in the slot. This allows the installer to tighten the screws to engage the flange, without having to simultaneously hold the clamp in place. The screws may bite into the flange, providing a more secure coupling between the clamp and the structure flange. The clamp may be used to mount a variety of objects, such as sway braces for seismic bracing.

Abstract: A system, method and computer program product are provided. Commands are received for executing a risk-assessment scan from a remote computer utilizing a network. The commands are processed on a local computer utilizing an agent. Further, the risk-assessment scan is performed on the local computer in accordance with the processed commands to remotely detect local vulnerabilities on the local computer. Such agent includes a plurality of risk-assessment modules. Further, the commands execute the risk-assessment modules in a specific manner that is configured at the remote computer.

Abstract: The present disclosure provides for systems and method for producing hybrid seed. In various embodiments, the disclosure provides a system for the high-throughput, nondestructive sampling of seeds. In another embodiment, a high-throughput, nondestructive method for producing hybrid seeds comprises removing a sample from a plurality of seeds in the population while preserving the germination viability of the seed and analyzing the sample for the presence or absence of one or more genetic markers indicative of a male-sterile gene.

Abstract: A structural clamp or connector has a retaining mechanism for engaging at least one threaded rod or threaded rod end by pressing the threads of the threads of the rod or rod end into a threadform of a clamp body or connector body. The clamp may include one or more retaining clips for pushing the threaded rod into engagement with threads on one side of one or more threaded holes through a clamp body of the clamp.

Abstract: Systems and methods are disclosed for enabling a switched digital video (SDV) client to intelligently generate and transmit reverse request in a SDV system. In this manner, reverse channel traffic is reduced. During rapid channel changes using the up and down keys on a remote control, the SDV client waits a predetermined amount of time before generating a reverse request that is subsequently transmitted upstream to a headend server. By way of example, changing broadcasted channels quickly will not generate a reverse request until the predetermined amount of time is over. In the event that a changed channel is an SDV session, a program select request is immediately generated in order to begin receiving the SDV session.

Abstract: Systems and methods are disclosed for enabling a switched digital video (SDV) server to prioritize SDV programs. More specifically, SDV programs carried on an RF carrier frequency are given priorities in the event of unavailable bandwidth. In this manner, the SDV server selects which SDV programs to broadcast, to unbind, or not to fulfill.

Abstract: An electronically-controlled locker system that utilizes distributing processing to control access to, and assignment of, a plurality of lockers in a school, workplace, fitness center, etc. The system uses a plurality of locker control units that control access to a corresponding set of lockers based on user inputs and on user/locker authorization data that is provided from a central administrator workstation. This administrator workstation communicates with a system control unit that is in communication with every locker control unit and which allows cross-communication between locker control units.

Abstract: Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance. Furthermore, many of the resistant tumors actually appear to be stimulated by tamoxifen just as they are by estrogens. The present invention provides methods of predicting endocrine resistance comprising detecting the biological activity and/or expression of p38 MAPK and/or AIB1. The invention further provides methods of reducing, reversing, or preventing endocrine resistance comprising contacting a breast or prostate tumor with a p38 MAPK pathway inhibitor.

Abstract: The present invention regards predicting a response to a therapy using RNA expression profiling. In particular, a resistance to a chemotherapy, such as tamoxifen, is predicted by comparing expressed genes in a patient on the therapy to a patient sensitive to the chemotherapy. In further embodiments, there is an RNA expression profile indicative of tamoxifen resistance in an individual. In additional embodiments, the RNA expression profile comprises DUSP6 EBP50, and/or RhoGDIa.

Abstract: A system, method and computer program product are provided for detecting modifications to risk assessment scanning caused by an intermediate device. Initially, a risk assessment scan is initiated on a target from a remote source utilizing a network. Next, it is determined whether the risk assessment scan involves an intermediate device coupled between the target and the remote source. Results of the risk assessment scan are then received from the target utilizing the network. If it is determined that the risk assessment scan involves the intermediate device, an administrator is notified for executing additional security measures.

Abstract: The present invention regards predicting a response to a therapy using RNA expression profiling. In particular, a resistance to a chemotherapy, such as tamoxifen, is predicted by comparing expressed genes in a patient on the therapy to a patient sensitive to the chemotherapy. In further embodiments, there is an RNA expression profile indicative of tamoxifen resistance in an individual. In additional embodiments, the RNA expression profile comprises DUSP6 EBP50, and/or RhoGDIa.

Abstract: A system, method and computer program product are provided for executing a risk-assessment scan with a variable timeout duration which is set based on network conditions. Initially, network conditions are measured in a network coupled between a source and a target. Subsequently, a risk-assessment scan is executed on the target from the source. A timeout is performed prior to making a determination that the target is failing to respond to the risk-assessment scan. Such timeout includes a variable duration which is set as a function of the measured network conditions.

Abstract: A system, method and computer program product are provided for remotely detecting vulnerabilities on a local computer. Initially, an agent is installed on a local computer for receiving encrypted commands from a remote computer utilizing a network. Next, the commands are decrypted and processed on the local computer utilizing the agent. A risk-assessment scan is then performed on the local computer utilizing the agent in accordance with the processed commands for the purpose of remotely detecting local vulnerabilities on the local computer.

Abstract: Constellations (22) arranged in a concentric circle pattern provide simplified control of modulated communication. A plurality of concentric circles (26, 28, 30) with defined points (24) include convolutionally coded and uncoded bits. Constellation patterns having three or four concentric circles (26, 28, 30) are provided. A magnitude error for each of the points (24) allows for deviations during communication. The constellations (22) provide efficient communication using non-linear channels.

Abstract: A system, method and computer program product are provided for minimizing the duration of a risk-assessment scan. Initially, a plurality of risk-assessment modules are selected each including vulnerability checks associated with a risk-assessment scan. Thereafter, a first set of ports is determined. Such first set of ports is required for communicating with network components subject to the risk-assessment modules associated with the risk-assessment scan. A port scan is subsequently executed on the first set of ports. Based on such port scan, a second set of ports is determined which includes ports unavailable for communicating with the network components subject to the risk-assessment modules associated with the risk-assessment scan. The risk-assessment modules associated with the second set of ports may then be disabled to minimize the duration of the risk-assessment scan.