Abstract: The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono-indolylquinones of high purity and pharmaceutical compositions containing the same.

Abstract: Ink jet ink compositions containing an aqueous carrier medium, an aqueous carrier medium insoluble colorant, a structured polymeric dispersant and a film-forming polyacrylamide polymer having a weight average molecular weight of 500-100,000 exhibit reduced film cracking, rapid drying, excellent image definition, are storage stable and have excellent decap properties and, when used in combination with a differently colored ink, result in reduced bleed in multi-colored printed elements.

Abstract: A solder delivery and array device for soldering electronic components and/or IC chips to printed circuit boards (PCB) or substrates comprises solder performs with predetermined weight, size, shape, and a flexible retaining means with spaced openings according to the layout of pins or leads of the components and/or IC chips. The solder performs are positioned and fixed in the openings through mechanical locking. The devices are located between components and PCB or substrate during the soldering processing. By using these devices, through hole type components and surface mount type parts can be attached onto the PCB through heat reflow soldering at same time without the wave soldering process, and overheating can be avoided during the soldering process especially for the pin grid array component. Another bonus for the application of the device is shorting the required lead time for research and development in new electronic products.

Abstract: A multiple data layer dye-based optical disk drive uses a disk with a light transmissive substrate onto which the laser light at a single wavelength is incident. The disk substrate supports at least two spatially separated data layers formed of dye material. The disk is either an air-gap structure wherein each data layer is supported on a separate substrate and the substrates are separated by an air-gap, or a solid structure wherein a solid light transmissive spacer layer separates the data layers. The invention makes use of the characteristic anomalous dispersion absorption band of certain dye materials, in which at a specific wavelength the dye material exhibits a high index of refraction and low extinction coefficient. This allows the first data layer (the one nearest the incident laser light) and intermediate data layers to exhibit both sufficient absorption when the laser is focused on those data layers and high transmissivity when the laser is focused on the last or farther data layers.

Abstract: The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.

Abstract: Optical laser amplifier devices are formed integrally with spontaneous emission filters. The filtering function is accomplished by a laser amplifier whose output is employed to quench the signal generated by a laser. The quenching of the laser is performed in direct proportion to the stimulated emission component of the laser amplifier output signal. Since the stimulated emission component represents the output signal minus any spontaneous emission noise, the output signal generated by the laser is an amplified, inverted version of the input signal without the noise components. In the preferred embodiments, optical waveguides are employed to form the laser amplifier and the laser is either a horizontal cavity edge emitting laser or a vertical cavity surface emitting laser (VCSEL).

Abstract: The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.

Abstract: An optical disk drive uses an optical disk with spatially separated multiple phase-change WORM recording layers. The optical disk has a light transmissive substrate onto which the laser light is incident. The substrate supports at least two spatially separated multi-film recording stacks, each stack including an active recording layer of phase-change WORM material. The disk is either an air-gap structure wherein each recording stack is supported on a separate substrate and the substrates are separated by an air-gap, or a solid structure wherein a solid light transmissive spacer layer separates the recording stacks. Each of the recording stacks located between the substrate on which the laser light is incident and the farthest recording stack includes an active phase-change recording layer and an optical interference film in contact with the recording layer.

Abstract: In a television receiver, to prevent interference between the magnetic field used for degaussing and the magnetic field of the vertical yoke, a switch is used for delaying turning on the vertical deflection circuit during degaussing.

Abstract: A single-sided ablative write-once optical disk is usable without a protective cartridge. The disk includes the conventional radiation-transparent polycarbonate substrate that has one surface serving as the disk outer face and an opposite surface that supports the fluorinated hydrocarbon subbing layer and the tellurium-based active data layer. The tellurium alloy in the data layer flows to form holes when subjected to incident laser radiation through the substrate. A multilayer protective coating is formed over the tellurium-based layer and has an outer surface that serves as the other outer face for the disk. The multilayer protective coating includes a deformable layer formed directly on the tellurium-based layer and a scratch-resistant hardcoat formed on the deformable layer. The deformable layer has sufficient hardness and modulus of elasticity to permit the tellurium alloy to flow at conventional laser power levels. In one embodiment the deformable layer is a silicone elastomer.

Abstract: Glyco-amino acids or glycopeptides that have three-dimensionally stable configuration for the presentation of functional groups, fucose, or an analogue or derivative thereof, covalently linked to an amino acid or peptide with a free carboxylic acid group, that facilitate binding between those groups and receptors on selectins, represented by the general structural formula I.

Abstract: A method and apparatus for using a cursor movement device such as a mouse device to position and orient a graphical object or cursor on a computer screen. The movement and orientation of the graphical object on the screen depends directly upon the path of motion of the cursor. The actual movement of the graphical object is similar to the dragging of an object through a viscous medium. In this manner, a two dimensional object can be moved and rotated on a planar display device with only two directional inputs. Also, the cursor, itself, can be treated as a graphical object. This allows the user to rotate the cursor to a desired orientation. Furthermore, the orientation of the cursor can be used to select one of a plurality of functions performed by the cursor movement device.

Abstract: A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue). In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e.sup.(-t/.tau. 1.sup.) +A.sub.2 e.sup.(-t/.tau. 2.sup.), one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.

Abstract: Method for aiding sheet metal forming tool design, for use with a computer including memory, and forming tools including a draw die, punch and binder having surfaces designed to form the sheet metal into a part, the sheet metal being represented as a mesh including a plurality of nodes. The method includes evaluating an initial binder-set associated with an initial binder surface design during a first stage of forming the sheet metal in which at least one of the plurality of sheet metal mesh nodes is forced against the binder surface, and detecting an area of unacceptable deformation on the sheet metal mesh. The method also includes identifying the at least one of the plurality nodes forced against the binder surface associated with the unacceptable sheet metal deformation and releasing the at least one of the plurality of nodes identified, so as to allow the identified nodes to move as the sheet metal assumes a relaxed state.

Abstract: An ion-exchange chromatography technique for purifying crude proteins containing closely related impurities, wherein the isoelectric points of the desired protein and the impurities are determined, is disclosed. In performing this technique, the pH for the ion-exchange chromatography is adjusted to a point between the ranges of isoelectric points of the protein fractions to be separated whereby, upon contacting the crude protein mixture at such pH with an ion exchange resin, the proteins in the first and second fractions are oppositely charged and only one of the fractions binds to the ion exchange resin. The application of the technique to the purification of GM-CSF using cation exchange resin is also disclosed.

Abstract: An optical data storage system comprises a multiple data surface medium and optical head. The medium comprises a plurality of substrates separated by a light transmissive medium. Data surfaces are located on the substrate surfaces. A layer of a dye material is deposited onto each of the data surfaces. The thickness of the dye layer determines the amount of reflectivity for each of the data surfaces.

Abstract: A capacitive accelerometer includes electrode plates supported and aligned for movement in the direction of a substrate in which they are supported. Preferably, the plates are formed a surface micro machining, and each plate includes capacitor forming surfaces aligned at an acute angle with respect to each other. In addition, each capacitive accelerometer is formed as a differential capacitor so that one movable plate is disposed between to relatively stationary plates and a plurality of stationary and movable plates are aligned in a series along a portion of the substrate. The suspension comprises a cantilevered support arrangement for the plates.

Abstract: Derivatives of anthraquinone and anthracene are synthesized and formulated into pharmaceutical formulations. When the formulations are administered the derivatives act as ligands binding to an interrupting the biological chain of events associated with selectin receptors in the human body.

Abstract: Method for predicting post-buckling deformation of a sheet of metal during a draw forming process, for use with a computer including memory, by introducing a set of springs to stabilize the sheet metal close to the onset of buckling, thereby enhancing convergence of numerical solutions. The method is for use with sheet metal forming tools including a draw die, a punch and binder having surfaces designed to form the sheet metal into a part, the sheet metal being represented as a mesh including a plurality of nodes. The method includes applying a displacement increment to the sheet metal nodes and identifying a singularity in a tangent stiffness matrix associated with the sheet metal close to the onset of buckling. The method also includes introducing a plurality of springs at the sheet metal nodes so as to eliminate the singularity and enhance convergence of the numerical solution of the displacement increment.

Abstract: Method and system for evaluating sheet metal forming tooling design, for use with a draw die including a punch and binder designed to form the sheet metal into a part, utilizing improved implicit time integration methods that reduce numerical instability, thereby enhancing convergence of numerical solutions. The sheet metal and tool surface of the punch are each represented as a mesh having a plurality of nodes. Contact nodes between the sheet metal mesh nodes and the tool surface mesh can be identified. A first embodiment includes minimizing discontinuities generated by unloading by determining a stress increment of a sampling point in the sheet metal mesh according to an incremental deformation theory of plasticity. A second embodiment includes modelling a draw-bead as a plurality of nonlinear elastic springs to minimize discontinuities in the spring force during unloading.