Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.

Abstract: Systems and methods for performing operations on a well include first and second flow control devices positioned between upper and lower sections of a conduit. An upper connector assembly engaged with the upper section includes connectors adapted for connection to a chemical stimulation device, a blowout preventer, or other well intervention apparatuses. A lower connector assembly engaged with the lower section includes connectors adapted for connection to a chemical stimulation device, a running tool, wellbore conduits, or other well intervention apparatuses. The two connector assemblies, above and below the flow control devices, enable sequential or simultaneous operations to be performed, and can enable operations to be performed independent of the state of the flow control devices.

Abstract: A steering system and method are described for a vehicle having steerable front and rear wheels. A rear hydraulic steering device may be coupled to one or more of the rear wheels. A rear valve assembly may hydraulically control the rear hydraulic steering device to steer the rear wheels based upon a rear steering command. In a rear steering assist mode, the rear steering command may be determined based upon a manual steering input received at a steering input device. In an automated steering mode, the rear steering command may be determined based upon a target path of the agricultural vehicle that is determined independently of the manual steering input.

Abstract: A computer controlled locomotive brake (CCB) configured for setting and releasing the retainer valves of the railcars of a train. The CCB may initially recharge the brake pipe to a pressure slightly less than the retainer valve release pressure. The CCB may then continue charging to this level until the brake pipe flow, measured at the CCB on the controlling locomotive and the brake pipe pressure on the last car, as measured by an end of train device, indicate that the pressure in the braking system reservoirs are substantively equal to the brake pipe pressure. Once the reservoirs are substantively charged, the CCB may complete the brake release and recharge by recharging the brake pipe pressure to its final charge so that all retainer valves are released and the train has sufficient braking system recharge to safely control movement of the train.

Abstract: A golf club comprises a shaft, a club head, and a connection assembly that allows the shaft to be easily disconnected from the club head. In particular embodiments, the connection assembly includes a removable hosel sleeve that allows a shaft to be supported a desired predetermined orientation relative to the club head. In this manner, the shaft loft and/or lie angle of the club can be adjusted without resorting to traditional bending of the shaft. In another embodiment, the club head has an adjustable sole that can be adjusted upwardly and downwardly relative to the strike face of the club head, which is effective to adjust the face angle of the club head.

Abstract: A submersible pumping system that is operable under hydrostatic pressure. The system suitably comprises a prime mover submersible within a first fluid; a pump means submersible within the first fluid and sealably coupled to the prime mover; and a fluid source in fluid communication with the prime mover, the fluid source providing a second fluid effective to act on the prime mover to power the pump means; wherein the second fluid is discharged in the first fluid after acting on the prime mover; and wherein the second fluid has a chemical composition substantially similar to the first fluid.

Abstract: Described are improved electrodialysis (ED) desalination systems and methods comprising voltage regulation and/or improved stack geometries. The systems and methods provide product water concentrations suitable for drinking (having a total dissolved solids concentration of less than 500 mg/L or 500 ppm) and have a high product recovery ratio.

Abstract: The disclosure relates to articles of footwear and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil on the outsoles. In particular, the disclosure relates to articles of footwear and components thereof including an outsole with an external hydrogel film having a water uptake capacity at 24 hours greater than 40% by weight. The outsoles can prevent or reduce the accumulation of soil on the footwear during wear on unpaved surfaces such as sporting fields. When the outsoles are wetted with water, the outsoles can become more compliant and/or can rapidly uptake and/or expel water, which can prevent soil from adhering to the outsole and/or can assist in shedding soil present on the outsole.

Abstract: A method is described for making an elasticized absorbent article having a waist opening and a pair of leg openings. First, multiple distributions of elastics are applied on a moving material sheet to form a moving web of an elastic composite. Then, each of a core section and a second material sheet is periodically applied onto the moving web to define a finished web of discrete elastic composite bodies. In subsequent steps, discrete absorbent pants articles are shaped from the finished web.

Abstract: A railway air dryer that switches the flow and counter flow of air through each of two desiccant towers in response to the actual humidity of air being dried by the air dryer. The air dryer includes a humidity sensor, a temperature sensor in the outlet air, and a temperature sensor in the inlet air stream to determine when to initiate the regeneration of the desiccant. The air dryer system is generally specified to provide some minimum drying performance, for example 40° C. dew point suppression.

Abstract: A system for determination of intraocular pressure includes: an intraocular pressure sensor; a light source illuminating the sensor with one or more wavelengths of light; and a detector that measures emitted light from the sensor. The sensor includes a substrate member, a spacer member, and a flexible membrane, which define a sealed cavity. The flexible membrane moves in response to intraocular pressure changes. A device for measuring intraocular pressure includes: the sensor; an anchoring member attached to the sensor for immobilizing the sensor in an eye; and a protective member attached to the anchoring member and covering the sensor to prevent contact between the flexible membrane and the eye. A method for determination of intraocular pressure includes: placing the sensor in an eye; illuminating, with a light source, the sensor with one or more wavelengths of light; and detecting, with a detector, a resultant light that contains information about intraocular pressure.

Abstract: A steering system and method is described for a vehicle having steerable front and rear wheels, and a steering input device for receiving manual steering input. Front and rear hydraulic steering devices may be coupled, respectively, to the front and rear wheels. Front and rear valve assemblies may be configured, respectively, to steer the front and rear wheels. In a manual steering mode, the front valve assembly may be disabled with respect to the front steering device, and the front hydraulic steering device may steer the front wheels based upon the manual steering input. In a rear steering assist mode, a rear steering command may be determined based upon the manual steering input, and the rear wheels steered based upon the rear steering command. In an automated steering mode, the front and rear wheels may be automatically steered based upon a target path of travel for the vehicle.

Abstract: A steering system and method for a vehicle having steerable front and rear wheels has rear hydraulic steering device that may be coupled to one or more of the rear wheels. A rear valve assembly may hydraulically control the rear hydraulic steering device to steer the rear wheels based upon a rear steering command from a controller. In a manual steering mode, the controller does not determine a rear steering command for the rear valve assembly such that the rear wheels are freely rotatable. In a rear steering assist mode, the controller determines the rear steering command based upon, at least in part, the manual steering input.

Abstract: The disclosure relates to articles of footwear and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil on the outsoles. In particular, the disclosure relates to articles of footwear and components thereof including an outsole with a ground-facing crosslinked polymeric network film having a swell thickness increase at 1 hour greater than 20%. The outsoles can prevent or reduce the accumulation of soil on the footwear during wear on unpaved surfaces such as sporting fields. When the outsoles are wetted with water, the outsoles can become more compliant and/or can rapidly uptake and/or expel water, which can prevent soil from adhering to the outsole and/or can assist in shedding soil present on the outsole.

Abstract: Components for articles of footwear and athletic equipment are provided including a foam. A variety of foams and foam components are provided. The articles include a composition having a foam structure, wherein the composition includes an ionomeric polymer and a plurality of cations, wherein the ionomeric copolymer is crosslinked by the cations. The crosslinks are ionic, so in some aspects the composition is free or essentially free of any covalent crosslinks between the ionomers. In particular, midsoles including the foams are provided for use in an article of footwear. Methods of making the compositions and foams are provided, as well as methods of making an article of footwear including one of the foam components. In some aspects, the foams and foam components can be made by injection molding or injection molding followed by compression molding.

Abstract: The disclosure relates to articles of footwear and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil on the outsoles. In particular, the disclosure relates to articles of footwear and components thereof including an outsole having a dispersion present on a ground facing surface of the outsole. The dispersion compositionally includes a polymeric continuous phase and a hydrophilic dispersant, and exhibits a water uptake rate greater than 20 grams/(meter2-minutes1/2). The outsoles can prevent or reduce the accumulation of soil on the footwear during wear on unpaved surfaces such as sporting fields. When the outsoles are wetted with water, the outsoles can become more compliant and/or can rapidly uptake and/or expel water, which can prevent soil from adhering to the outsole and/or can assist in shedding soil present on the outsole.

Abstract: An intelligent locomotive brake control system which selects and optimizes use of dynamic, independent, and automatic brakes on the locomotive to assure intended brake power, to minimize in-train forces, minimize brake component wear, and to automate standard train brake protocol. The system may be programmed to alter an automatic brake application commanded by a train driver to omit or reduce the amount of the automatic brake application in favor of a dynamic brake application, and independent brake application, or combination thereof.

Abstract: A fan inlet diffuser housing includes a housing body of composite material and includes a heat exchanger interface portion positioned between an ejector housing portion and a bypass housing portion. A first transition region is formed between the heat exchanger interface portion and the ejector housing portion including an air cycle machine end reinforcement patch proximate to a heat exchanger interface. The air cycle machine end reinforcement patch includes a first patch thickness and a second patch thickness, and a ratio of the first patch thickness to the second patch thickness is between 2.02 and 3.11. An ejector is formed having an ejector gap width between a nozzle portion and a diffuser portion within the ejector housing portion of the housing body. The diffuser portion has a downstream ejector gap width, and a ratio of the downstream ejector gap width to the ejector gap width is between 4.62 and 5.01.

Abstract: The disclosure relates to articles of footwear and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil on the outsoles. In particular, the disclosure relates to articles of footwear and components thereof including an outsole with a ground-facing crosslinked polymeric material having a wet-state contact angle less than 80°. The outsoles can prevent or reduce the accumulation of soil on the footwear during wear on unpaved surfaces such as sporting fields. When the outsoles are wetted with water, the outsoles can become more compliant and/or can rapidly uptake and/or expel water, which can prevent soil from adhering to the outsole and/or can assist in shedding soil present on the outsole.

Abstract: The disclosure relates to articles of footwear and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil on the outsoles. In particular, the disclosure relates to articles of footwear and components thereof including an outsole with an external hydrogel film that compositionally includes a crosslinked polymeric network having a plurality of copolymer chains with one or more hard segments physically crosslinked to other hard segments of the copolymer chains, and one or more hydrophilic soft segments covalently bonded to the hard segments. The outsoles can prevent or reduce the accumulation of soil on the footwear during wear on unpaved surfaces such as sporting fields. When the outsoles are wetted with water, the outsoles can become more compliant and/or can rapidly uptake and/or expel water, which can prevent soil from adhering to the outsole and/or can assist in shedding soil present on the outsole.