Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: A powered hand brake for locomotive brakes that latches a brake chain into a locked position after the brake cylinder has applied the locomotive brakes. A computer controlled brake system may be interconnected to the brake cylinder and the latch and programmed to set the latch into the latched position when the brake cylinder has moved the locomotive brake into the applied position. An actuator is coupled to the brake chain to take up slack in the brake chain as the brake chain moves between the first and second positions. The actuator can comprise a motor or a tensioning cylinder that takes up slack in the brake chain after the brakes have been applied. Alternatively, the actuator may comprise a linkage connecting the brake chain to the locomotive brake so that the slack in the brake chain is taken up as the brakes are applied.

Abstract: A method of making an absorbent composite that includes a first fabric, a second fabric, and particles positioned between the two fabrics and absorbent articles made from the absorbent composite. The particles are secured between the two fabric using adhesive, thermal plastic or combinations thereof. The fabrics are bonded together in a manner that limits particle movement between the fabrics. The bond pattern may define pockets or other shapes. In applications in which the bond pattern forms pockets, the particles may be positioned in the pockets. The particles may be SAP particles or other particles with advantageous properties.

Abstract: The disclosure relates to articles and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil. In particular, the articles has a substrate body, a material including a hydrogel secured to the substrate body, and a mesh component present on and/or adjacent to a second side of the hydrogel-containing material opposing the first side. The article can prevent or reduce the accumulation of soil during use.

Abstract: The disclosure relates to articles and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil. In particular, the articles have substrate body, a tie layer secured to the substrate body, and a material including a hydrogel secured to the tie layer. The material can prevent or reduce the accumulation of soil during use. The presence of the tie layer can minimize or prevent delamination of the hydrogel containing material during normal use.

Abstract: An article of manufacture has an external surface at least partly defined by a material compositionally comprising a polymeric hydrogel that takes up water when wetted. The hydrogel-containing material is effective in reducing soil accumulation on, and/or for reducing soil adhesion to, an article designed for a variety of uses, such as transportation, vehicle safety, storage, recreation, leisure, waste disposal, construction, gardening, or traffic control.

Abstract: The disclosure relates to articles and components thereof, including outsoles, which can be used in conditions normally conducive to the accumulation of soil. In particular, the disclosure relates to articles and components thereof with a material including a hydrogel, where the hydrogel-containing material defines an external surface or side of an article. The hydrogel-containing material can prevent or reduce the accumulation of soil during use. A portion of the hydrogel-containing material is embedded into a substrate body, or a portion of the hydrogel-containing material is disposed on the outer side surface of the substrate body in a junction. The substrate body can have a lip extending from a shaft such that the shaft and the lip form the junction. Embedding the material in the substrate body, or disposing it in the junction, can minimize or prevent delamination of the hydrogel containing material during normal use.

Abstract: An adjustable fall arrest system is disclosed, where the system employs a four-bar linkage and cantilevered beam arrangement to provide the fall arrest support.

Abstract: The disclosure relates to articles of footwear (100) and components thereof, including outsoles (112), which can be used in conditions normally conducive to the accumulation of soil on the outsoles (112). In particular, the disclosure relates to articles of footwear (100) and components thereof including an outsole (112) with a material (116) including a polymeric network formed of a plurality of polymer chains, where the material (116) defines external ground-facing surface or side of the outsole (112). The outsoles (112) can prevent or reduce the accumulation of soil on the footwear (100) during wear on unpaved surfaces such as sporting fields.

Abstract: An article of footwear (100), apparel (500, 600), and/or sporting equipment (300, 400), and methods of manufacturing thereof, having a hydrogel present on at least a portion of an externally-facing side of the article. The hydrogel is effective in reducing soil accumulation on the article, and/or for reducing soil adhesion to the article.

Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

Abstract: In one system, there is an emergency pipe stroker tool, wherein the emergency pipe stroker tool is configured to act as a first mechanical barrier for a well. Further, there is an emergency quick disconnect tool in communication with the emergency pipe stroker tool, wherein the emergency quick disconnect tool comprises a connector assembly and a fluid conduit in communication with the well, and further wherein the connector assembly is configured to simultaneously detach from the well and to seal the well. Further still, there is a cement retainer in communication with the emergency quick disconnect tool and the emergency pipe stroker tool, wherein the cement retainer is configured to act as a second mechanical barrier for the well, wherein, the emergency pipe stroker tool, the emergency quick disconnect tool, and the cement retainer act in coordination to seal a well while establishing the multiple mechanical barriers.

Abstract: A wellhead capable of steering fluid flow to minimize contact with equipment in the wellbore comprises a central bore and a plurality of side bores coupled to injection ports. The plurality of side bores comprise a rifled internal surface having a circular or helical configuration into which fluids can be injected. The side bores intersect with the central bore at a mixing chamber, which also comprises a rifled internal surface. By injecting fluids into the wellbore through these ports, the operator can create a vortex utilizing the full capacity of the wellhead while minimizing contact with any wireline equipment.

Abstract: Embodiments usable within the scope of the present disclosure relate generally to a connector apparatus and methods usable to securely and repeatedly connect a sub-sea fluid conduit to another fluid conduit or well equipment, such as a manifold, a wellhead, a BOP, or other associated items. The disclosed embodiments further relate to systems and methods usable to remotely disconnect the fluid conduit and automatically shut off fluid flow therethrough. The male connector includes a flow control valve adapted to open upon connection with a female connector and to close upon disconnection from the female connector. The female connector is adapted to actuate the flow control valve of the male connector to the open position. The male connector includes a biasing member that actuates the flow control valve of the male connector to the closed position.

Abstract: A disposable absorbent article has a central body defining a first waist end region including a first end edge, a second waist end region spaced longitudinally from the first waist end region and including a second end edge, and a crotch region positioned therebetween. An absorbent core is situated between the end edges, and includes a plurality of elastics incorporated therewith such that the core is substantially laterally contracted in a narrowed region about the elastics. The absorbent core includes at least one end region that is substantially non-elasticized and has a lateral width substantially wider than that of the narrowed region.

Abstract: A channel guide distributor of a heat exchanger including a flanged body, a nozzle fluidly connected to the flanged body, a diffuser fluidly connected to the nozzle, a pin operably connected to the nozzle, a cone operably connected to the nozzle and a post removably connected to the flanged body and configured to receive the diffuser. The post having a tubular portion, an open end, a closed end, an inner surface, an outer surface, a post longitudinal axis, and twenty-four apertures in the tubular portion. The apertures are aligned linearly along the post longitudinal axis and equidistantly spaced. A diameter of the outer surface of the tubular portion is about 1.156±0.003 inches (2.936±0.01 centimeters).

Abstract: A locomotive brake system includes a brake cylinder with an integrated parking brake; a main reservoir; and a brake system controller for controlling the pressure in the brake cylinder. The brake system uses main reservoir pressure to pressurize the brake cylinder to achieve the parking brake output force using the brake cylinder.

Abstract: A branch pipe tee for a rail car having a length that is below standard. The branch pipe tee has a standard mount for connecting to the brake pipe and branch pipe as well as integral volume that compensates for the reduced brake pipe length of the rail car. The integral volume is dimensioned to make the effective brake pipe length of rail car fall within standard ranges so that the braking system of the rail car can perform normally and avoid the need for additional equipment to compensate for the length of the rail car.

Abstract: A sole structure that includes at least one auxetic structure and methods of making are disclosed. A sole structure includes a plate, a first cleat, and an auxetic structure. The plate has an upper surface and a lower surface. The first cleat extends from the lower surface, the first cleat having a first height and having a first tip surface. The auxetic structure has an inner surface affixed to the lower surface and having an outer surface. The inner surface is constrained by the lower surface. The outer surface is spaced closer to the lower surface than to the first tip surface.

Abstract: A pressure control system is described for a vehicle having a hydraulically actuated header. The system may include a hydraulic lifting circuit for raising and lowering the header, a hydraulic float circuit for floating the header, and a drain tank. A lifting circuit control valve may be configured to control drainage of hydraulic fluid from the hydraulic lifting circuit to the drain tank. A float circuit control valve may be configured to control drainage of hydraulic fluid from the hydraulic float circuit to the drain tank. A user interface may be configured to receive one or more inputs to control drainage of hydraulic fluid from the hydraulic circuits. Based upon the one or more inputs, at least one of the control valves may be opened, in order to depressurize, respectively, one of the hydraulic circuits.