Abstract: The present disclosure relates to a water purification apparatus that comprises a reverse osmosis device, RO-device, producing a purified water flow and to a corresponding method. The proposed method comprises detecting at least one fluid property of purified water in the purified water path and regulating a flow rate of water in the recirculation path to fulfill one or more predetermined criteria of the purified water in the purified water path, based on the at least one detected fluid property. The present disclosure also relates to a computer program and a computer program product implementing the method.

Abstract: Methods of treating or preventing at least one sign or symptom of restless leg syndrome or related disorders are disclosed. The methods comprise identifying a host, afflicted with restless leg syndrome or related disorders; and administering to the host a pharmaceutically effective amount of a fruit of Ficus carica plant or an extract thereof. Also provided are methods and compositions for treating or preventing sleep disorders, and methods and compositions for improving sleep adequacy and quantity.

Abstract: Provided herein are methods and compositions for treating, mitigating, or preventing Parkinson's disease by administration of an anti-malassezial agent wherein the anti-malassezial agent is oteseconazole, tavaborole or 2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol.

Abstract: A system and a related method for forming a multi-chamber package are disclosed. The system includes a single web of a film material extending in a machine direction and defining a plurality of lateral lanes extending contiguously in a cross-machine direction, orthogonal to the machine direction. The system also includes a forming arrangement configured to interact with the web to form chambers along a second lane of the plurality of lateral lanes in the machine direction, a first filling device configured to deposit a first substance into one or more of the formed chambers of the second lane, and a first folding mechanism configured to form a fold between the lateral lanes in the machine direction such that a first lane of the plurality of lateral lanes is directed to overlie the one or more formed chambers of the second lane.

Abstract: An apparatus for filling a chambered package can include a dispensing nozzle angled relative to a perpendicular of a machine direction of a carrying mechanism, the dispensing nozzle being disposed adjacent to the carrying mechanism having one or more chambered recess defined about a surface thereof, the dispensing nozzle being configured to dispense a quantity of the medium into the one or more chambered recess defined about the surface of the carrying mechanism The apparatus includes a housing and at least one wiping material arranged to define an angle having a vertex toward the machine direction about a bottom surface of the housing, the angle of the at least one wiping material being configured to direct any of the quantity of the medium dispensed out of the second end of the dispensing nozzle, but not directed into the one or more chambered recess, into the one or more chambered recess.

Abstract: The present invention relates to a method of washing textile articles that can be carried out, for example, in a continuous batch tunnel washer. Embodiments of the present method can include treating the textile with an aqueous composition including cleaning agent and halogen-containing bleaching agent for a time sufficient to remove soil from the textile and contacting the halogen-treated textile with an aqueous composition including a peroxycarboxylic acid. The concentration of halogen after the sufficient time can be at a level that does not result in adverse interaction between the halogen-containing bleaching agent and the peroxycarboxylic acid. Embodiments of the present method can clean textiles with the results of more effective stain removal and less waste through destruction of the textile article. Further, the present invention can clean a textile contacted soiled by a composition including chlorhexidine gluconate without resulting staining of the textile, which staining could have been permanent.

Abstract: A method of washing textile articles can be carried out, for example, in a continuous batch tunnel washer. Embodiments of the present method can include treating the textile with an aqueous composition including cleaning agent and halogen-containing bleaching agent for a time sufficient to remove soil from the textile and contacting the halogen-treated textile with an aqueous composition including a peroxycarboxylic acid. The concentration of halogen after the sufficient time can be at a level that does not result in adverse interaction between the halogen-containing bleaching agent and the peroxycarboxylic acid. Embodiments of the present method can clean textiles with the results of more effective stain removal and less waste through destruction of the textile article. Further, the present invention can clean a textile contacted soiled by a composition including chlorhexidine gluconate without resulting staining of the textile, which staining could have been permanent.

Abstract: Methods, systems, and computer readable media for acoustic classification and optimization for multi-modal rendering of real-world scenes are disclosed. According to one method for determining acoustic material properties associated with a real-world scene, the method comprises obtaining an acoustic response in a real-world scene. The method also includes generating a three-dimensional (3D) virtual model of the real-world scene. The method further includes determining acoustic material properties of surfaces in the 3D virtual model using a visual material classification algorithm to identify materials in the real-world scene that make up the surfaces and known acoustic material properties of the materials. The method also includes using the acoustic response in the real-world scene to adjust the acoustic material properties.

Abstract: Methods, systems, and computer readable media for acoustic classification and optimization for multi-modal rendering of real-world scenes are disclosed. According to one method for determining acoustic material properties associated with a real-world scene, the method comprises obtaining an acoustic response in a real-world scene. The method also includes generating a three-dimensional (3D) virtual model of the real-world scene. The method further includes determining acoustic material properties of surfaces in the 3D virtual model using a visual material classification algorithm to identify materials in the real-world scene that make up the surfaces and known acoustic material properties of the materials. The method also includes using the acoustic response in the real-world scene to adjust the acoustic material properties.

Abstract: Methods, systems, and computer readable media for conducting interactive sound propagation and rending for a plurality of sound sources in a virtual environment scene are disclosed. According to one method, the method includes decomposing a virtual environment scene containing a plurality of sound sources into a plurality of partitions and forming a plurality of source group clusters, wherein each of the source group clusters includes two or more of the sound sources located within a common partition. The method further includes determining, for each of the source group clusters, a single set of sound propagation paths relative to a listener position and generating a simulated output sound at a listener position using sound intensities associated with the determined sets of sound propagation paths.

Abstract: Methods, systems, and computer readable media for utilizing ray-parameterized reverberation filters to facilitate interactive sound rendering are disclosed. According to one method, the method includes generating a sound propagation impulse response characterized by a plurality of predefined number of frequency bands and estimating a plurality of reverberation parameters for each of the predefined number of frequency bands of the impulse response. The method further includes utilizing the reverberation parameters to parameterize a plurality of reverberation filters in an artificial reverberator, rendering an audio output in a spherical harmonic (SH) domain that results from a mixing of a source audio and a reverberation signal that is produced from the artificial reverberator, and performing spatialization processing on the audio output.

Abstract: The present disclosure relates to computer-implemented methods, computer-readable media, and computer systems for gameplay operations related to a puzzle-based game. In one example, a method can include identifying a puzzle for use in a jigsaw puzzle application, the puzzle comprising a set of puzzle pieces forming a puzzle image. The puzzle is divided into a subset of chunks including mutually exclusive sets of interconnected pieces. The puzzle is presented to a player, where the presented puzzle illustrates the set of puzzle pieces and includes prompting the player to select a particular piece as a starting piece. In response, the chunk associated with the particular piece is identified. An area for solving the identified chunk associated with the particular piece is presented, where the area includes a solution area for solving the identified chunk and a player hand area for providing potential pieces for solving the identified chunk.

Abstract: A Barcode to Zipcode Application, the purpose of which is to remove as many steps from the supply chain as possible, reducing the time required to complete the process of purchasing goods in one location for delivery in another location to hours or even minutes. This application contains interfaces to location based retail product information services as well as customer payment processing systems. The application functions as an internet web application with the primary users being the customer service representatives and delivery personnel.

Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.

Abstract: Methods, systems, and computer readable media for conducting interactive sound propagation and rending for a plurality of sound sources in a virtual environment scene are disclosed. According to one method, the method includes decomposing a virtual environment scene containing a plurality of sound sources into a plurality of partitions and forming a plurality of source group clusters, wherein each of the source group clusters includes two or more of the sound sources located within a common partition. The method further includes determining, for each of the source group clusters, a single set of sound propagation paths relative to a listener position and generating a simulated output sound at a listener position using sound intensities associated with the determined sets of sound propagation paths.