Abstract: Methods, systems, and computer readable media for simulating sound propagation are disclosed. According to one method, the method includes decomposing a virtual environment scene including at least one object into a plurality of surface regions, wherein each of the surface regions includes a plurality of surface patches. The method further includes organizing sound rays generated by a sound source in the virtual environment scene into a plurality of path tracing groups, wherein each of the path tracing groups comprises a group of the rays that traverses a sequence of surface patches. The method also includes determining, for each of the path tracing groups, a sound intensity by combining a sound intensity computed for a current time with one or more previously computed sound intensities respectively associated with previous times and generating a simulated output sound at a listener position using the determined sound intensities.

Abstract: The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.

Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.

Abstract: The present invention relates to a method of washing textile articles that can be carried out, for example, in a continuous batch tunnel washer. Embodiments of the present method can include treating the textile with an aqueous composition including cleaning agent and halogen-containing bleaching agent for a time sufficient to remove soil from the textile and contacting the halogen-treated textile with an aqueous composition including a peroxycarboxylic acid. The concentration of halogen after the sufficient time can be at a level that does not result in adverse interaction between the halogen-containing bleaching agent and the peroxycarboxylic acid. Embodiments of the present method can clean textiles with the results of more effective stain removal and less waste through destruction of the textile article. Further, the present invention can clean a textile contacted soiled by a composition including chlorhexidine gluconate without resulting staining of the textile, which staining could have been permanent.

Abstract: A system and method for scheduling, and reminding people receiving care (PRC) about upcoming events uses a remote computer-based interface that allows a Caregiver at a remote location to schedule the events for the PRC. The PRC has in their residence (or other location) a device that prompts the PRC, by an audio and/or video prompt, so as to “nudge” the PRC, asking whether they intend to participate in a pre-scheduled event. A man-machine interface, such as a two input keypad containing one button labeled “yes” and another button labeled “no”, the remote Caregiver is able to monitor the responses of the electronic “nudges” offered by the system to the PRC. In turn, the device used by the remote Caregiver accumulates the responses and creates a history of the level of activity the person has indicated in which they wish to participate.

Abstract: The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.

Abstract: The present invention provides zinc finger nucleotide binding polypeptide variants that have at least three zinc finger modules that bind to a target cellular nucleotide sequence and modulate the transcriptional function of the cellular nucleotide sequence.

Abstract: A system and method for scheduling, and reminding people receiving care (PRC) about upcoming events uses a remote computer-based interface that allows a Caregiver at a remote location to schedule the events for the PRC. The PRC has in their residence (or other location) a device that prompts the PRC, by an audio and/or video prompt, so as to “nudge” the PRC, asking whether they intend to participate in a pre-scheduled event. A man-machine interface, such as a two input keypad containing one button labeled “yes” and another button labeled “no”, the remote Caregiver is able to monitor the responses of the electronic “nudges” offered by the system to the PRC. In turn, the device used by the remote Caregiver accumulates the responses and creates a history of the level of activity the person has indicated in which they wish to participate.

Abstract: A system and method for scheduling, and reminding people receiving care (PRC) about upcoming events uses a remote computer-based interface that allows a Caregiver at a remote location to schedule the events for the PRC. The PRC has in their residence (or other location) a device that prompts the PRC, by an audio and/or video prompt, so as to “nudge” the PRC, asking whether they intend to participate in a pre-scheduled event. A man-machine interface, such as a two input keypad containing one button labeled “yes” and another button labeled “no”, the remote Caregiver is able to monitor the responses of the electronic “nudges” offered by the system to the PRC. In turn, the device used by the remote Caregiver accumulates the responses and creates a history of the level of activity the person has indicated in which they wish to participate.

Abstract: One embodiment of the invention described herein includes a method for improving stability of an antiperspirant. The method includes preparing a blend that comprises dibenzylidene sorbitol; adding an antiperspirant active to the blend, to make an antiperspirant blend; and adding one or more alkaline earth silicate salts to the antiperspirant blend in a concentration effective for stabilizing the dibenzylidene sorbitol.

Abstract: A system and method for scheduling, and reminding people receiving care (PRC) about upcoming events uses a remote computer-based interface that allows a Caregiver at a remote location to schedule the events for the PRC. The PRC has in their residence (or other location) a device that prompts the PRC, by an audio and/or video prompt, so as to “nudge” the PRC, asking whether they intend to participate in a pre-scheduled event. A man-machine interface, such as a two input keypad containing one button labeled “yes” and another button labeled “no”, the remote Caregiver is able to monitor the responses of the electronic “nudges” offered by the system to the PRC. In turn, the device used by the remote Caregiver accumulates the responses and creates a history of the level of activity the person has indicated in which they wish to participate.

Abstract: Systemic delivery of Modafinil to the nasal mucous membrane elicits rapid systemic therapeutic response with reduced side effects compared to current methods of administration.

Abstract: A system and method for scheduling, and reminding people receiving care (PRC) about upcoming events uses a remote computer-based interface that allows a Caregiver at a remote location to schedule the events for the PRC. The PRC has in their residence (or other location) a device that prompts the PRC, by an audio and/or video prompt, so as to “nudge” the PRC, asking whether they intend to participate in a pre-scheduled event. A man-machine interface, such as a two input keypad containing one button labeled “yes” and another button labeled “no”, the remote Caregiver is able to monitor the responses of the electronic “nudges” offered by the system to the PRC. In turn, the device used by the remote Caregiver accumulates the responses and creates a history of the level of activity the person has indicated in which they wish to participate.

Abstract: One embodiment of the invention described herein includes a method for improving stability of an antiperspirant. The method includes preparing a blend that comprises dibenzylidene sorbitol; adding an antiperspirant active to the blend, to make an antiperspirant blend; and adding one or more alkaline earth silicate salts to the antiperspirant blend in a concentration effective for stabilizing the dibenzylidene sorbitol.

Abstract: One embodiment of the invention described herein includes a method for improving stability of an antiperspirant. The method includes preparing a blend that comprises dibenzylidene sorbitol; adding an antiperspirant active to the blend, to make an antiperspirant blend; and adding one or more alkaline earth silicate salts to the antiperspirant blend in a concentration effective for stabilizing the dibenzylidene sorbitol.

Abstract: One embodiment of the invention described herein includes a method for improving stability of an antiperspirant. The method includes preparing a blend that comprises propylene glycol and dibenzylidene sorbitol; adding an antiperspirant active solid powder to the blend, to make an antiperspirant blend, in a concentration effective for making an antiperspirant that provides antiperspirant protection to a user and improves process stability of the antiperspirant; and adding an amino acid salt to the antiperspirant blend in a concentration effective for stabilizing the dibenzylidene sorbitol.

Abstract: A process for making a water-soluble ?-hydroxynitrile. A 1,2-epoxide and an inorganic cyanide salt are reacted in a solvent having aqueous methanol and a buffer therein to form ?-hydroxynitrile. The buffer substantially inhibits the formation of reaction products other than ?-hydroxynitrile. Optionally, water may be removed from the ?-hydroxynitrile by azeotropic distillation with acetonitrile and subsequently purified via vacuum distillation and filtration.

Abstract: A method of making an interior trim panel for attachment to structure of a vehicle includes the steps of loading a trim blank into a cavity of a first side of a mold and depositing a molten thermoplastic material onto a core on the first side of the mold. The method also includes the steps of closing the mold, moving the slide in a channel of the core, and injecting a molten thermoplastic material into a second side of the mold to form the interior trim panel.

Abstract: A process for making a water-soluble &bgr;-hydroxynitrile. A 1,2-epoxide and an inorganic cyanide salt are reacted in a solvent having aqueous methanol and a buffer therein to form &bgr;hydroxynitrile. The buffer substantially inhibits the formation of reaction products other than &bgr;hydroxynitrile. Optionally, water may be removed from the &bgr;hydroxynitrile by azeotropic distillation with acetonitrile and subsequently purified via vacuum distillation and filtration.

Abstract: A method of making an interior trim panel for attachment to structure of a vehicle includes the steps of placing a trim insert into a cavity of an apparatus and over a first seal thereof. The method also includes the steps of loading a retainer over the trim insert to sandwich the trim insert between the retainer and the first seal and closing the apparatus. The method further includes the steps of filling the cavity with a plastic material and introducing steam into the apparatus to expand the plastic material to form a substrate and bonding the substrate against the trim insert to form an interior trim panel.