Patents by Inventor Carlo M. Croce

Carlo M. Croce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for diagnosing pancreatic cancer using MicroRNAs
    Patent number: 8507202
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: August 13, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8492083
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 23, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486913
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486912
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Compositions and methods for the diagnosis and therapy of BCL2-associated cancers
    Patent number: 8481505
    Abstract: The invention provides methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. The invention also encompasses methods for determining the efficacy of a cancer therapy in a subject and methods for inducing apoptosis of a cell.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: July 9, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • Ultraconserved regions encoding ncRNAs
    Patent number: 8465918
    Abstract: Described herein are methods for differentiate human cancers comprising using one or more transcribed ultraconserved regions (T-UCR) expression profiles where the association between the genomic location of UCRs and the analyzed cancer-related genomic elements is highly statistically significant and comparable to that reported for miRNAs.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: June 18, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells
    Patent number: 8465917
    Abstract: The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: June 18, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer
    Inventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
  • Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
    Patent number: 8466119
    Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: June 18, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Methods for Impairing the P53/HDM2 Auto-Regulatory Loop in Multiple Myeloma Development Using mIR-192, mIR-194 and mIR-215
    Publication number: 20130150430
    Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing multiple myeloma are described.
    Type: Application
    Filed: August 4, 2011
    Publication date: June 13, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Flavia Pichiorri
  • Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression
    Publication number: 20130139273
    Abstract: A mouse model and uses there of for detecting, treating, characterizing, and diagnosing various diseases are described.
    Type: Application
    Filed: June 20, 2011
    Publication date: May 30, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Yuri Pekarsky
  • MiR-182-, miR-191, miR-199a-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
    Patent number: 8431342
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML).
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: April 30, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155
    Publication number: 20130065946
    Abstract: The present invention provides materials and methods related to modulation of mismatch and genomic stability by miR-155.
    Type: Application
    Filed: March 22, 2011
    Publication date: March 14, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Nicola Valeri
  • Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer
    Publication number: 20130065938
    Abstract: Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described.
    Type: Application
    Filed: March 7, 2012
    Publication date: March 14, 2013
    Inventor: Carlo M. Croce
  • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
    Patent number: 8389210
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: March 5, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-17-3P
    Patent number: 8377637
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: February 19, 2013
    Assignees: The Ohio State University Research Foundation, Department of Health and Human Services
    Inventors: Carlo M. Croce, Nozomu Yanaihara, Curtis C. Harris
  • Method for diagnosing acute lymphomic leukemia (ALL) using miR-146a
    Patent number: 8372586
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: February 12, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Methods for reverting methylation by targeting methyltransferases
    Patent number: 8367632
    Abstract: Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: February 5, 2013
    Assignee: Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Muller Fabbri
  • Method for diagnosing acute lymphomic leukemia (ALL) using miR-221
    Patent number: 8361722
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 29, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-21
    Patent number: 8361710
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: January 29, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Department of Health and Human Services
    Inventors: Carlo M. Croce, Nozomu Yanaihara, Curtis C. Harris
  • Methods to Identify Chronic Lymphocytic Leukemia Disease Progression
    Publication number: 20130017964
    Abstract: The present invention provides materials and methods related to CLL disease progression. The invention provides methods related to differential expression signatures, including distinguishing histological subtypes, progression patterns, poor survival patterns, and disease-free survival patterns. Antisense and sense miRNAs, kits, and other compositions, such as pharmaceutical formulations and combination therapies are also provided.
    Type: Application
    Filed: January 11, 2012
    Publication date: January 17, 2013
    Inventor: Carlo M. Croce