Patents by Inventor Carlo M. Croce

Carlo M. Croce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8354224
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: January 15, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MiR-25-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
    Patent number: 8354229
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 15, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Method for diagnosing acute lymphomic leukemia (ALL) using miR-125b
    Patent number: 8349561
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Method of diagnosing poor survival prognosis colon cancer using let-7g
    Patent number: 8349568
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: January 8, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method for diagnosing acute lymphomic leukemia (ALL) using miR-222
    Patent number: 8349560
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Ohio State University Research
    Inventor: Carlo M. Croce
  • Method of diagnosing poor survival prognosis colon cancer using miR-10a
    Patent number: 8343725
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 1, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • MicroRNA Expression Signature for Predicting Survival and Metastases in Hepatocellular Carcinoma
    Publication number: 20120329672
    Abstract: Provided herein are microarrays, kits, methods and compositions for the diagnosis, prognosis and treatment of Hepatocellular carcinoma (HCC). Also provided are methods of identifying anti-HCC agents.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 27, 2012
    Inventors: Carlo M. Croce, Xin W. Wang, Anuradha Budhu, Zhao-you Tang
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120329859
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 27, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120329053
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 27, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Method of diagnosing poor survival prognosis colon cancer using miR-29a
    Patent number: 8338106
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-181b
    Patent number: 8338102
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-106a
    Patent number: 8338103
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Deparment of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-103-2
    Patent number: 8338104
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-203
    Patent number: 8338105
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Tansfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20120322859
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CLL) and Uses Thereof
    Publication number: 20120283310
    Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of leukemia associated diseases are disclosed.
    Type: Application
    Filed: June 28, 2012
    Publication date: November 8, 2012
    Inventors: Carlo M. Croce, George A. Calin
  • Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion
    Publication number: 20120252023
    Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
    Type: Application
    Filed: November 23, 2010
    Publication date: October 4, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventor: Carlo M. Croce
  • MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
    Patent number: 8252538
    Abstract: Provided herein are methods and compositions for the diagnosis, prognosis and treatment of Hepatocellular carcinoma (HCC). Also provided are methods of identifying anti-HCC agents.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: August 28, 2012
    Assignees: The Ohio State University, The United States of America as represented by the Secretary of the Department of Health and Human Services National Institute of Health, Office of Technology Transfer, Liver Cancer Institute and Zhongshan Hospital, Fudan University
    Inventors: Carlo M. Croce, Xin W. Wang, Anuradha Budhu, Zhao-you Tang
  • Methods for Diagnosing Lung Cancer Using MicroRNA Signatures
    Publication number: 20120214701
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for Diagnosing Pancreatic Cancer Using MicroRNAs
    Publication number: 20120214696
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Application
    Filed: February 28, 2012
    Publication date: August 23, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia