Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: A belt (1) with a first belt end (11) and a second belt end (12), both belt ends (11, 12) being connected together. The first belt end (11) has at least one first segment (13) and a second segment (14), and the second belt end (12) has at least one first segment (15) and a second segment (16). The first segment (13) of the first belt end (11) is connected to the first segment (15) of the second belt end (12) at least one connection element (17), and the second segment (14) of the first belt end (11) is connected to the second segment (16) of the second belt end (12) at least one other connection element (17). The first segment (13) of the first belt end (11) is offset in the longitudinal direction (X) in some sections relative to the second segment (14) of the first belt end (11), and the first segment (15) of the second belt end (12) is offset in the longitudinal direction (X) in some sections relative to the second segment (16) of the second belt end (12).

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: The present invention relates to a hook connector arrangement (1) for a conveyor belt (3) having a plurality of hook connectors (10), which are designed to hold between them an open end of the conveyor belt (3) at least by force fit, wherein the hook connectors (10) are connected to one another on the inside in a transverse direction (Y) by means of a connecting element (19). The hook connector arrangement (1) is characterized in that at least one hook connector (10) comprises on the inside a clamping element (2) which is arranged opposite the connecting element (19).

Abstract: The invention relates to a belt (1) with a first belt end (11) and a second belt end (12), both belt ends (11, 12) being connected together. The belt (1) is characterized in that the first belt end (11) has at least one first segment (13) and a second segment (14), and the second belt end (12) has at least one first segment (15) and a second segment (16).

Abstract: The present invention relate to a caterpillar track, in particular a rubber caterpillar track, with a track body ad with at least one outer profiling element, preferable with a plurality of outer profiling elements, which are directed outwardly away from the track body. The caterpillar track is characterized in that the outer profiling element has an outwardly directed grouser body and a grouser root, which connects the grouser body to the track body, wherein the outer profiling element has, at least in some sections, a marking which can make the boundary between the grouser body and the grouser root visually and haptically identifiable.

Abstract: The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention also relates to novel intermediates. Finally, the invention provides a pharmaceutical composition comprising the insulin derivatives of the invention and the use of such a composition in the treatment or prevention of medical conditions relating to diabetes.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: The present invention relates to a running gear chain (2), in particular a bogie chain (2), having a flexible body (20), preferably an elastomer body (20), which is closed in endless fashion, or closable in endless fashion, in a running direction (A). The running gear chain (2) according to the invention is characterized by a multiplicity of rigid transverse elements (24) which are connected to the outer side of the flexible body (20) and extend substantially transversely with respect to the running direction (A), wherein at least some of the rigid transverse elements (24), preferably all of the rigid transverse elements (24), are arranged so close together in the running direction (A) that, with a planar extent of the flexible body (20), two immediately adjacent rigid transverse elements (24) make contact in the running direction (A).

Abstract: The present invention relates to a pouch conveyor belt with a conveyor belt body, preferably an elastomer conveyor belt body, which is designed to hold a conveyed material in the interior of the closed pouch conveyor belt. The pouch conveyor belt is characterized in that the conveyor belt body comprises at least one sensor element which is configured to detect at least the temperature of the conveyor belt body at the location of the sensor element.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein “X” is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I?), which is: R1?-X?—R2?, in which either the moeities R1? or R2? or X? carry a drug that is covalently attached to the diboron compound.

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

Abstract: The present invention relates to a pocket-type conveyor belt installation (2) having a plurality of carrying rollers (21) which are designed to support a pocket-type conveyor belt (1), preferably a lower conveyor belt edge (12) of a pocket-type conveyor belt (1), wherein the carrying rollers (21) are each connected in load-bearing fashion by means of at least one carrying roller holder (22) to a carrying frame (23) of the pocket-type conveyor belt installation (2). The pocket-type conveyor belt installation (2) is characterized in that at least one carrying roller holder (22), preferably a plurality of carrying roller holders (22), has at least one sensor element (4), which is arranged and designed to record at least a force and/or a change in force between the carrying roller (21) and the carrying frame (23).

Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

Abstract: The present invention relates to a pouch conveyor belt with a conveyor belt body, preferably an elastomer conveyor belt body, which is designed to hold a conveyed material in the interior of the closed pouch conveyor belt. The pouch conveyor belt is characterized in that the conveyor belt body comprises at least one sensor element which is configured to detect at least the temperature of the conveyor belt body at the location of the sensor element.

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.