Abstract: Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof.

Abstract: A smart pen including: a body part; a nib part at an end of the body part; a code detection unit for receiving light reflected from a display panel and the nib part, wherein the light reflected from the display panel and the nib part is used to detect shape data for code patterns of the display panel; and a code processor for generating coordinate data based on the shape data and transmitting the coordinate data to a main processor for driving the display panel based on the coordinate data.

Abstract: The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

Abstract: A smart pen includes a body, a pen tip portion at an end of the body, and including a pen tip extending in a first direction, a pen tip support configured to support the pen tip, and a reflector on one surface of the pen tip support, and having a curvature, and a light emitter supported by the body, configured to emit light, and inclined at an angle with respect to the first direction.

Abstract: Disclosed is a method for manufacturing a ceramic susceptor, the method including: preparing ceramic sheets; preparing a lamination structure of a molded body, in which the ceramic sheets are laminated and a conductive metal layer for electrodes is disposed between the ceramic sheet laminated products; and sintering the lamination structure of the molded body, wherein the preparing of the ceramic sheets includes: obtaining a vitrified first additive powder by heat-treating a slurry containing MgO, SiO2, and CaO; preparing a slurry by mixing an Al2O3 powder with the first additive powder, a second additive powder containing a MgO powder, and a third additive powder containing a Y2O3 powder; and forming the ceramic sheets by tape casting the slurry.

Abstract: The present disclosure relates to an anti-inflammatory peptide including at least one selected from the group consisting of the amino acid sequences of SEQ ID NOS: 1 to 63 and modifications thereof, an anti-inflammatory composition comprising the same, and a pharmaceutical composition for preventing or treating inflammatory diseases. An anti-inflammatory peptide according to an embodiment of the present disclosure has no cytotoxicity, and has an effect of inhibiting the activation of mitochondrial antiviral signaling protein (MAVS), immune/inflammatory activation mechanism and the expression or activity of inflammatory cytokines and inflammasomes. Therefore, the peptide can be applied to an anti-inflammatory composition or a composition for treating inflammatory diseases.

Abstract: An ultrasonic welding device for a secondary battery is provided. The ultrasonic welding device is configured to weld an overlapping surface of an electrode tab and an electrode lead in an electrode assembly. The ultrasonic welding device includes an anvil on which the overlapping surface of the electrode tab and the electrode lead are disposed. A horn is configured to apply ultrasonic waves to the overlapping surface of the electrode tab and the electrode lead while pressing the overlapping surface. The overlapping surface is disposed on the anvil. An electrode tab measuring part is configured to measure a thickness of the electrode tab disposed on the overlapping surface. A pressure adjusting device is configured to adjust a pressure applied to the overlapping surface by the anvil and the horn according to the thickness value of the electrode tab. The thickness value is measured by the electrode tab measuring part.

Abstract: The present invention is provided with a secondary battery comprising: an electrode assembly to which an electrode lead is bonded; a pouch configured to accommodate the electrode assembly and provided with a sealing part; and a lead film configured to seal a portion between the sealing part and the electrode lead, wherein a pattern means configured to pattern the sealing part and the lead film so as to increase in bonding area between the sealing part and the lead film is provided on a bonding portion between the sealing part and the lead film. Therefore, bonding force and sealing force between the lead film and the sealing part may increase.

Abstract: Provided is a light emitting device including a first electrode, a hole transport region on the first electrode, a first light emitting layer on the hole transport region and configured to emit light of a first wavelength, a second light emitting layer on the hole transport region and configured to emit light of a second wavelength different from the first wavelength, an electron transport region including an electron transport layer on the first light emitting layer and the second light emitting layer, and an electron injection layer on the electron transport layer, and a second electrode on the electron transport region, wherein the electron injection layer includes magnesium (Mg) and ytterbium (Yb).

Abstract: An electrostatic discharge (ESD) protection circuit including a detection circuit, a voltage-divider element, and a discharge element is provided. The detection circuit is coupled between a first power line and a second power line. In response to an ESD event, the detection circuit enables a turn-on signal. The voltage-divider element is coupled between the first power line and a third power line and receives the turn-on signal. The discharge element is coupled between the second and third power lines. In response to the turn-on signal being enabled, the first discharge element discharges an ESD current.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: The present invention relates to a light guide plate including a plurality of cutting areas, the light guide plate capable of solving the problem of brightness degradation between the plurality of cutting areas by attaching a predetermined member, which is reactive to light, to at least one of the inner sides of the cutting areas.

Abstract: An ultrasonic welding device includes an anvil provided so that an overlapping surface of an electrode tab and an electrode lead, which are provided in an electrode assembly, are configured to be disposed thereon; a horn configured to weld the overlapping surface disposed on the anvil; and an inspection member configured to inspect a horizontal level of an opposing member with respect to the overlapping surface, based on an overlapping surface horizontal value that is a horizontal value of the overlapping surface with respect to a predetermined reference surface and an opposing horizontal value that is a horizontal value of the opposing member, which is one of a welding part of the horn configured to face the overlapping surface and a disposing part of the anvil, on which the overlapping surface is configured to be disposed, with respect to the predetermined reference surface.

Abstract: A woven article for a carbon fiber reinforced plastic according to the present invention is a woven article of a spun yarn containing: about 10 wt % to about 60 wt % of a carbon fiber staple in which the content of carbon components is equal to or greater than about 97 wt %; and about 40 wt % to about 90 wt % of a thermoplastic resin fiber, wherein the carbon fiber staple is obtained by carbonizing carbon fiber reinforced plastic scrap at a temperature of about 900 to about 1400° C. The woven article for a carbon fiber reinforced plastic includes a carbon fiber staple manufactured from scrap generated during manufacture of the carbon fiber reinforced plastic, and allows economic recycling of the carbon fiber reinforced plastic scrap without a reduction in mechanical properties. When molded, productivity is high due to a short cycle time, there is almost no orientation, and an excellent flexural modulus is exhibited.

Abstract: The present invention relates to a constructing method for delaying corrosion of radioactive waste disposal container in concrete disposal vault and, more specifically, to a constructing method for delaying corrosion of radioactive waste disposal container in concrete disposal vault in which backfill, placed to the top, combines pH control capsules, thereby dissolving the pH control capsules in rainwater, and a pH controller, inside, is discharged, thereby preventing decrease of pH of the backfill below 8.5 and delaying corrosion in the disposal containers, upon filling in backfill after placing radioactive waste disposal containers in the concrete vault.

Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.

Abstract: Described herein are methods and compositions relating to anti-Chi3L1 antibodies, antibody reagents, and antigen-binding fragments thereof which display superior properties, e.g., high sensitivity, high specificity, high binding affinity, neutralization activity ex vivo and in vivo (e.g., blocks Chi3L1-induced MAPK and AKT signaling). Methods of treatment, e.g., of treating cancer, obesity, and/or asthma by administering the compounds described herein are also provided.

Abstract: A non-volatile memory device includes a memory cell which stores one of first data and second data, and includes a first sub-memory cell connected to a first word line and a first bit line, and a second sub-memory cell connected to a second word line and a second bit line, a source line shared by the first sub-memory cell and the second sub-memory cell, and a sense amplifier connected to the first bit line and the second bit line which reads data stored in the memory cell. The sense amplifier receives a first current from the first bit line, receives a second current from the second bit line, and reads data stored in the memory cell by comparing magnitudes of the first current and the second current. The first sub-memory cell is programmed, and the second sub-memory cell is erased, in response to the memory cell storing the first data.

Abstract: A foldable display device, includes: a flexible display module including a first non-bendable portion, a second non-bendable portion spaced from the first non-bendable portion in a first direction, and a bendable portion disposed between the first non-bendable portion and the second non-bendable portion; and a support disposed on the flexible display module, the support including a patterned portion having a first pattern and a second pattern alternatively disposed along a second direction intersecting the first direction, wherein the first pattern includes a first discontinuity having a first shape, and the second pattern includes a second discontinuity having a second shape different from the first shape.

Abstract: The present invention relates to a system for monitoring electrical properties of materials of deep bedrock samples for estimating nuclide movement in disposal site of spent fuel and, more specifically, to a system for monitoring electrical properties of materials of deep bedrock samples for estimating nuclide movement in disposal site of spent fuel which installs a tube wherein ring-shaped potential electrode is formed in multi layers inside a column; adheres the potential electrode to deep bedrock samples by pressing on the external side of the tube while filling the deep bedrock samples inside of the tube; and reproduces real condition of deep bedrock and monitors precisely by measuring electrical resistivity for each location of the deep bedrock samples while injecting nuclide and underground water to the inside the tube.