Patents by Inventor Chang Xu
Chang Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8748459Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTlF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.Type: GrantFiled: February 1, 2012Date of Patent: June 10, 2014Assignee: Eli Lilly and CompanyInventors: Michael Philip Cohen, Daniel Timothy Kohlman, Sidney Xi Liang, Frantz Victor, Yao-Chang Xu, Bai-Ping Ying, DeAnna Piatt Zacherl, Deyi Zhang
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Publication number: 20140136126Abstract: A system for determining densities and proportions of phases in a multi-phase fluid flow (MFF) that can include an oil phase, a water phase, and a gas phase from a well. The system includes a first density sensor that senses the MFF at locations where the phases of the MFF are often separated, a second density sensor senses the MFF from the output of a phase mixer-homogenizer, and a third density sensor that senses, in real time, the MFF where the gas phase starts to separate or has separated from the liquid phase but where the liquid phases have not separated. The system also includes one or more processors for executing one or more programs to determine a density of the oil phase, a density of the water phase, a density of the gas phase, and proportions of phases including a water cut and a gas volume fraction based on readings from the first, second, and third density sensors.Type: ApplicationFiled: November 15, 2012Publication date: May 15, 2014Applicant: General Electric CompanyInventors: Xiaolei Shirley Ao, Oleg Alexander Khrakovsky, Yue Ma, Shawn Li Doria, Jin Chang Xu
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Publication number: 20140076201Abstract: A coated metal pigment that has excellent passivation, dispersion and adhesion properties, a method for producing the coated metal pigment and a coating composition that includes the coated metal pigment are described.Type: ApplicationFiled: September 14, 2012Publication date: March 20, 2014Applicant: SILBERLINE MANUFACTURING CO. INC.Inventors: Anand SUNDARARAMAN, Yungwan KWAK, Craig KEEMER, John BUCHALA, Mary Kate THOMAS, Chang XU, Parfait Jean Marie LIKIBI
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Publication number: 20130329930Abstract: Acoustic waveguides are disclosed for mounting to a conduit. The acoustic waveguides provide a mounting area that minimizes the effect of the mount on the acoustic wave traveling through the waveguide while providing an effective seal, even under high pressure conditions.Type: ApplicationFiled: August 19, 2013Publication date: December 12, 2013Applicant: General Electric CompanyInventors: Xiaolei Shirley Ao, Jin Chang Xu, John Albert Umina
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Publication number: 20130245002Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: ApplicationFiled: September 13, 2012Publication date: September 19, 2013Applicant: NOVARTIS AGInventors: Chao CHEN, Haibing DENG, Haibing GUO, Feng HE, Lei JIANG, Fang LIANG, Yuan MI, Huixin WAN, Yao-Chang XU, Hongping YU, Ji Yue ZHANG
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Patent number: 8511424Abstract: Acoustic waveguides are disclosed for mounting to a conduit. The acoustic waveguides provide a mounting area that minimizes the effect of the mount on the acoustic wave traveling through the waveguide while providing an effective seal, even under high pressure conditions.Type: GrantFiled: December 8, 2011Date of Patent: August 20, 2013Assignee: General Electric CompanyInventors: Xiaolei Shirley Ao, Jin Chang Xu, John Albert Umina
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Patent number: 8507676Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: GrantFiled: August 6, 2012Date of Patent: August 13, 2013Assignee: Novartis AGInventors: Miao Dai, Xingnian Fu, Feng He, Lei Jiang, Yue Li, Fang Liang, Lei Liu, Yuan Mi, Yao-Chang Xu, Guoliang Xun, Xiaoxia Yan, Zhengtian Yu, Ji Yue Zhang
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Patent number: 8497368Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: GrantFiled: August 10, 2010Date of Patent: July 30, 2013Assignee: Novartis AGInventors: Feng He, Miao Dai, Xingnian Fu, Yue Li, Lei Liu, Yuan Mi, Yao-chang Xu, Guoliang Xun, Zhengtian Yu, Ji Yue Zhang
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Publication number: 20130146388Abstract: Acoustic waveguides are disclosed for mounting to a conduit. The acoustic waveguides provide a mounting area that minimizes the effect of the mount on the acoustic wave traveling through the waveguide while providing an effective seal, even under high pressure conditions.Type: ApplicationFiled: December 8, 2011Publication date: June 13, 2013Applicant: General Electric CompanyInventors: Xiaolei Shirley Ao, Jin Chang Xu, John Albert Umina
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Patent number: 8410264Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: GrantFiled: August 19, 2010Date of Patent: April 2, 2013Assignee: Novartis AGInventors: Miao Dai, Xingnian Fu, Feng He, Lei Jiang, Yue Li, Fang Liang, Lei Liu, Yuan Mi, Yao-chang Xu, Guoliang Xun, Xiaoxia Yan, Zhengtian Yu, Ji Yue Zhang
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Publication number: 20120329820Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.Type: ApplicationFiled: February 1, 2012Publication date: December 27, 2012Applicant: Eli Lilly and CompanyInventors: Michael P. Cohen, Daniel T. Kohlman, Sidney X. Liang, Frantz Victor, Yao-Chang Xu, Bai-Ping Ying, Deanna P. Zacherl, Deyi Zhang
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Patent number: 8337609Abstract: A pearlescent effect pigment having an opaque, dark or black color is disclosed. The black pearlescent pigment includes a platelet-shaped non-metal substrate, optionally an oxide layer, a template layer, and a metal layer. The pearlescent luster of the disclosed effect pigment is comparable to those of pure pearlescent effects. The disclosed method provides a cost-effective approach for the manufacturing of the disclosed effect pigment.Type: GrantFiled: December 1, 2009Date of Patent: December 25, 2012Assignee: Silberline Manufacturing Co., Inc.Inventors: Shufang Yu, Peter Llyod Redmond, Hai Hui Lin, Chang Xu, Parfait Jean Marie Likibi
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Publication number: 20120302570Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: ApplicationFiled: August 6, 2012Publication date: November 29, 2012Applicant: NOVARTIS AGInventors: Miao DAI, Xingnian FU, Feng HE, Lei JIANG, Yue LI, Fang LIANG, Lei LIU, Yuan MI, Yao-Chang XU, Guoliang XUN, Xiaoxia YAN, Zhengtian YU, Ji Yue ZHANG
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Publication number: 20120184491Abstract: The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.Type: ApplicationFiled: January 17, 2012Publication date: July 19, 2012Inventors: Frederick Sachs, Philip Gottlieb, Thomas Suchyna, Seth L. Alper, David H. Vandorpe, Chang Xu
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Publication number: 20120142681Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: ApplicationFiled: August 10, 2010Publication date: June 7, 2012Applicant: NOVARTIS AGInventors: Feng He, Miao Dai, Xingnian Fu, Yue Li, Lei Liu, Yuan Mi, Yao-chang Xu, Guoliang Xun, Zhengtian Yu, Ji Yue Zhang
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Publication number: 20120022198Abstract: A colored system including a coated substrate and a color pigment that adheres to the coated substrate, and a method for producing the colored system are described. The disclosed method adheres effectively the color pigments to the coated substrates. The resulting colored system avoids their separation during coating applications. The colored metallic paints/inks can be prepared by mixing a color pigment solution with a coated substrate solution. The resulting colored system displays vivid color and strong metallic luster.Type: ApplicationFiled: July 20, 2010Publication date: January 26, 2012Applicant: SILBERLINE MANUFACTURING COMPANY, INC.Inventors: Chang XU, Craig KEEMER, Hai Hui LIN, Parfait Jean Marie LIKIBI
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Publication number: 20120022181Abstract: A coated pigment that includes polymer encapsulations which act as a pigment dispersant and film forming agent, coating systems that include the coated pigment and methods for producing the coated pigment and the coating system are described. The polymer encapsulations of the coated pigments allow the coated pigments that are included in the coating system to be dispersed without the addition of any other dispersants and/or resins. Thus, the disclosed coated pigments simplify the process of making coating systems. The disclosed coated pigments also extend the shelf-life of the coating systems, and provide a final coating with enhanced pigment orientation and aesthetics.Type: ApplicationFiled: July 20, 2010Publication date: January 26, 2012Applicant: SILBERLINE MANUFACTURING COMPANY, INC.Inventors: Chang XU, Hai Hui LIN, Parfait Jean Marie LIKIBI
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Publication number: 20110130510Abstract: A coated platelet that includes a robust polymer coating that has substantially uniform structures, a method for producing the coated platelet and a system that includes the coated platelet are described. The disclosed method involves immobilizing initiator molecules onto the surfaces of the platelet by using surface coupling groups and polymerization from initiating sites of the initiator anchored on the surface of the platelet. The disclosed method allows uniform growth of the polymer chains so as to produce robust coated platelets with a smooth coated surface. The disclosed system includes only the disclosed coated platelet and a solvent and eliminates the need to add polymer resins separate from the resins that are covalently attached to the platelet.Type: ApplicationFiled: October 14, 2010Publication date: June 2, 2011Applicant: SILBERLINE MANUFACTURING COMPANY, INC.Inventors: Chang XU, Hai Hui LIN, Parfait Jean Marie LIKIBI
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Publication number: 20110126735Abstract: A pearlescent effect pigment having an opaque, dark or black color is disclosed. The black pearlescent pigment includes a platelet-shaped non-metal substrate, optionally an oxide layer, a template layer, and a metal layer. The pearlescent luster of the disclosed effect pigment is comparable to those of pure pearlescent effects. The disclosed method provides a cost-effective approach for the manufacturing of the disclosed effect pigment.Type: ApplicationFiled: December 1, 2009Publication date: June 2, 2011Applicant: SILBERLINE MANUFACTURING COMPANY, INC.Inventors: Shufang YU, Chang XU, Hai Hui LIN, Parfait Jean Marie LIKIBI, Peter Lloyd REDMOND
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Publication number: 20110065708Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).Type: ApplicationFiled: August 19, 2010Publication date: March 17, 2011Applicant: NOVARTIS AGInventors: Miao DAI, Xingnian FU, Feng HE, Lei JIANG, Yue LI, Fang LIANG, Lei LIU, Yuan MI, Yao-chang XU, Guoliang XUN, Xiaoxia YAN, Zhengtian YU, Ji Yue ZHANG