Abstract: A series of aryl piperazine compounds of the formula: 1

Abstract: Described herein is a compound of the formula wherein Ar′ is a mono or bicyclic aromatic or heteroaromatic radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R1 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio; R2 is phenyl, naphthyl or (C3-C12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; X is —(C═O)—; or a pharmaceutically acceptable salt racemate, optical isomer or solvat

Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Abstract: The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

Abstract: A method for potentiating the action of a serotonin reuptake inhibitor in increasing the availability of serotonin, norepinephrin and dopamine in the brain, comprising administering to a patient in need of such treatment a serotonin reuptake inhibitor in combination with an effective amount of a compound of the formula 1

Abstract: The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

Abstract: The present invention provides the compounds of the following formula: Wherein the variables are as defined in the specification and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of the compound of above formula.

Abstract: A computer system includes a plurality of interdependent processors for operating a common set of applications. Each interdependent processor executes an independent operating system image without sharing file system state information. Each interdependent processor has a network access card with a first network connection and a second network connection. The computer system includes a first active backplane coupled to each first network connection of each processor; a second active backplane coupled to each second network connection of each processor, the second active backplane operating in lieu of the first active backplane in case of a fail-over; and one or more directors coupled to the first and second active backplanes, each of the one or more directors load-balancing requests directed at a plurality of servers.

Abstract: An improved transducer arrangement for low frequency sonar projectors that convert electric signals to mechanically generated acoustic signals. In one embodiment the arrangement has both a convex flextensional transducer and a concave flextensional transducer. An open side of the convex transducer is attached to an open side of the concave transducer by an intermediate bulkhead which closes each of the attached open sides. An end plate is attached to another open side of the convex transducer and another end plate is attached to another open side of the concave transducer such that the end plates close the attached open sides. In another embodiment, transducer assembly has a convex transducer having end plates and a concave transducer having end plates. Either one of the endplates of the concave transducer is attached to one of the endplates of the convex transducer, or an endplate of the concave transducer is also an endplate of the concave transducer.

Abstract: A class of novel aminotetralins is disclosed useful as 5-HT1D&agr; agonists.

Abstract: A computer system includes a plurality of interdependent processors. Each interdependent processor executes an independent operating system image without sharing file system state information, and each interdependent processor further has a network access card with a first network connection and a second network connection. The computer system has a first active backplane coupled to each first network connection of each processor; a second active backplane coupled to each second network connection of each processor, the second active backplane operating in lieu of the first active backplane in case of a fail-over; and one or more peripherals connected to each of the first and second active backplanes and responsive to data requests transmitted over the first and second active backplanes.

Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Abstract: A class of novel aminotetralins is disclosed useful as 5-HT1D&agr; agonists.

Abstract: The present invention provides the compounds of the following formula (I): and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of formula (I).

Abstract: Anylpiperazines of formula (1) useful as serotonin reuptake inhibitors and 5-HT1D&agr; receptor antagonists are disclosed herein: wherein R1 and R2 are each independently hydrogen, halo, —(C1-C6)alkyl or —(C1-C6)alkoxy; R3 is hydrogen or —(C1-C6)alkyl; Y is —CO— or —CH2—; Z is —NH—, —N(COR)— or —CH2— where R is —(C1-C6)alkyl or —(C3-C8)cycloalkyl; represents a double or single bond; n and m are an each independently integer from 1 to 3, both inclusive; or a pharmaceutically acceptable salt thereof.

Abstract: An improved transducer arrangement for low frequency sonar projectors that convert electric signals to mechanically generated acoustic signals. In one embodiment the arrangement has both a convex flextensional transducer and a concave flextensional transducer. An open side of the convex transducer is attached to an open side of the concave transducer by an intermediate bulkhead which closes each of the attached open sides. An end plate is attached to another open side of the convex transducer and another end plate is attached to another open side of the concave transducer such that the end plates close the attached open sides. In another embodiment, transducer assembly has a convex transducer having end plates and a concave transducer having end plates. Either one of the endplates of the concave transducer is attached to one of the endplates of the convex transducer, or an endplate of the concave transducer is also an endplate of the concave transducer.

Abstract: An improved transducer arrangement for low frequency sonar projectors that convert electric signals to mechanically generated acoustic signals. In one embodiment the arrangement has both a convex flextensional transducer and a concave flextensional transducer. An open side of the convex transducer is attached to an open side of the concave transducer by an intermediate bulkhead which closes each of the attached open sides. An end plate is attached to another open side of the convex transducer and another end plate is attached to another open side of the concave transducer such that the end plates close the attached open sides. In another embodiment, transducer assembly has a convex transducer having end plates and a concave transducer having end plates. Either one of the endplates of the concave transducer is attached to one of the endplates of the convex transducer, or an endplate of the concave transducer is also an endplate of the concave transducer.

Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Abstract: A series of aryl piperazine compounds of the formula: or the pharmaceutically acceptable salts thereof, are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Abstract: A computer system has a plurality of processors, each processor executing an independent operating system image without sharing file system state information. The system includes an active backplane coupled to the plurality of processors; and one or more data storage devices coupled to the active backplane for satisfying data requests from the plurality of processors, each of the data storage devices being adapted to secure a file when one processor writes to the file and to release the file when the processor completes operation on the file.