Patents by Inventor Changjun Yu

Changjun Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrodes linked via oligomers to nucleic acids
    Publication number: 20060099631
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Application
    Filed: December 6, 2005
    Publication date: May 11, 2006
    Inventors: Jon Kayyem, Stephen O'Conner, Michael Gozin, Changjun Yu, Thomas Meade
  • Conductive oligomers attached to electrodes and nucleoside analogs
    Patent number: 7014992
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: March 21, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Electrodes linked via conductive oligomers to nucleic acids
    Patent number: 6977151
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: December 20, 2005
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Chemical ligation of nucleic acids
    Publication number: 20050208503
    Abstract: The invention relates to the field of nucleic acid analysis. More particularly, the invention relates to compositions and methods used for the detection of sequence variations or single nucleotide polymorphisms (SNPs) in a nucleic acid of interest.
    Type: Application
    Filed: March 16, 2004
    Publication date: September 22, 2005
    Inventors: Handy Yowanto, Changjun Yu
  • Methods and devices for measuring diffusion by magnetic resonance imaging
    Publication number: 20050163713
    Abstract: The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.
    Type: Application
    Filed: December 10, 2004
    Publication date: July 28, 2005
    Inventors: Julian Tyszka, Changjun Yu, Daniel Schwartz, Ilene Sugino, Scott Fraser
  • Target analyte detection using asymmetrical self-assembled monolayers
    Publication number: 20050003398
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Application
    Filed: April 12, 2004
    Publication date: January 6, 2005
    Inventors: Chunlin Tao, Changjun Yu
  • Target analyte detection using asymmetrical self-assembled monolayers
    Patent number: 6753143
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chunlin Tao, Changjun Yu
  • Nucleic acid reactions using labels with different redox potentials
    Publication number: 20030232354
    Abstract: The present invention is directed to methods and compositions for the use of electron transfer moieties with different redox potentials to electronically detect nucleic acids, particularly for the electrochemical sequencing of DNA.
    Type: Application
    Filed: January 2, 2003
    Publication date: December 18, 2003
    Inventors: Changjun Yu, Yitzhak Tor
  • Electrodes linked via conductive oligomers to nucleic acids
    Publication number: 20030150723
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Application
    Filed: September 5, 2002
    Publication date: August 14, 2003
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
  • Nucleic acid reactions using labels with different redox potentials
    Publication number: 20030143556
    Abstract: The present invention is directed to methods and compositions for the use of electron transfer moieties with different redox potentials to electronically detect nucleic acids, particularly for the electrochemical sequencing of DNA.
    Type: Application
    Filed: April 30, 2002
    Publication date: July 31, 2003
    Inventors: Gary Blackburn, Jon Faiz Kayyem, Chunlin Tao, Changjun Yu
  • Electronic methods for the detection of analytes utilizing monolayers
    Patent number: 6600026
    Abstract: The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: July 29, 2003
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Changjun Yu
  • ELECTRONIC DETECTION OF NUCLEIC ACIDS USING MONOLAYERS
    Publication number: 20030087228
    Abstract: The present invention is directed to the electronic detection of nucleic acids using self-assembled monolayers.
    Type: Application
    Filed: January 27, 1999
    Publication date: May 8, 2003
    Inventors: CYNTHIA BAMDAD, CHANGJUN YU
  • Electrodes linked via conductive oligomers to nucleic acids
    Publication number: 20030003473
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Application
    Filed: February 20, 2002
    Publication date: January 2, 2003
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Electrodes linked via conductive oligomers to nucleic acids
    Patent number: 6479240
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: November 12, 2002
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
  • Target analyte detection using asymmetrical self-assembled monolayers
    Publication number: 20020121314
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Application
    Filed: May 1, 2001
    Publication date: September 5, 2002
    Applicant: Clinical Micro Sensors
    Inventors: Chunlin Tao, Changjun Yu
  • METHODS OF MAKING MODIFIED NUCLEOSIDES
    Publication number: 20020004593
    Abstract: The invention is directed to novel methods of making nucleosides modified with signalling moieties and polydentate ligands, particularly for use in chelating transition metal complexes to form signalling moieties such as electron transfer moieties and fluorophores.
    Type: Application
    Filed: November 13, 1998
    Publication date: January 10, 2002
    Inventors: THOMAS J. MEADE, CHANGJUN YU
  • Methods of detecting nucleic acids using electrodes
    Patent number: 6221583
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: April 24, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Electrodes linked via conductive oligomers to nucleic acids
    Patent number: 6096273
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: August 1, 2000
    Assignee: Clinical Micro Sensors
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Methods of attaching conductive oligomers to electrodes
    Patent number: 6090933
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: July 18, 2000
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade