Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors and/or genetically modified to enhance one or more aspects of the efficacy of the immune cells in cellular immunotherapy. Several embodiments relate to genetic modifications which reduce potential side effects of cellular immunotherapy. In several embodiments, combinations of cells are used to achieve both rapid and long-term tumor reduction with reduced or eliminated potential for graft versus host effects.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: A system is provided for supporting cash currency exchange. The system included a server, a first client requesting cash-currency-exchange service, and at least one second client providing the cash-currency-exchange service. The first client sends an exchange-service request of cash currency to the server. The server receives the exchange-service request, obtains the at least one second client, and pushes an exchange-service item corresponding to the exchange-service request to the at least one second client. The second client receives the exchange-service item, and sends a confirmation response to the server. The server pushes information about the at least one second client sending the confirmation response to the first client; and the first client displays the obtained information about the second client, determines a second client as a target client, and triggers an eWallet of the first client to transfer a specified amount to an eWallet of the target client.

Abstract: Examples described herein provide multi-band channel scanning. Examples may include transmitting, by a first radio of a first network device operating at a first frequency band below the millimeter-wave (mmWave), a beacon frame indicating a particular scanning channel of a second frequency band within the mmWave, receiving, by a second radio of the first network device operating the second frequency band, a probe request from a second network device via the particular scanning channel, wherein the probe request is in response to the beacon frame received by the second network device, and in response to the probe request, transmitting, by the second radio of the first network device, a probe response in each of one or more sector transmitting directions via the particular scanning channel.

Abstract: Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.

Abstract: The present invention relates to a method for preparing a chenodeoxycholic acid derivative. Particularly, disclosed is a method for carrying out one-pot reduction on a compound represented by Formula (VI), i.e., 3?-hydroxyl-ethidene-7-ketone-5?-chole-24-alkamide, to obtain a compound represented by Formula (V), i.e., 3?,7?-dyhydroxyl-6?-ethyl-5?-cholanic acid, and then carrying out salt formation crystallization to obtain a high-purity obeticholic acid sodium salt, a potassium salt, a magnesium salt, and a calcium salt.

Abstract: A connector has a first end provided with a first interface and a second end provided with a second interface. The second interface includes a first switch unit and a second switch unit, where the second switch unit is connected to a control terminal of the first switch unit and a ground pin of the second interface, and a preset reference voltage is input into the ground pin of the second interface. In a case that the second interface is disconnected from a to-be-charged device, the first switch unit is in an off state. In a case that the second interface is connected to the to-be-charged device, the ground pin of the second interface is connected to a ground pin of the to-be-charged device, the ground pin of the second interface is grounded, and the first switch unit is in an on state.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors (CAR) and/or genetically modified to reduce potential side effects of cellular immunotherapy. Several embodiments relate to genetic modifications to the immune cells, such as Natural Killer (NK) cells, to reduce, substantially, reduce, or eliminate expression of a marker by the immune cells that would otherwise cause them to be self-targeted by the CAR. In several embodiments, the CAR targets CD70, and in some embodiments is used for renal cell carcinoma immunotherapy.

Abstract: The present application relates to a positive electrode plate and an electrochemical device. The positive electrode plate includes a current collector, a positive active material layer, and a binding layer disposed between the current collector and the positive active material layer, the binding layer comprising a polymer material, a conductive material, and an inorganic filler, wherein the polymer material comprises a binding layer matrix and the binding layer matrix is an oil-dispersible polymer material having a solubility in NMP at 130° C. for 5 minutes, which is 30% or less of the solubility of PVDF under the same conditions. The positive electrode plate can improve the safety performance of the electrochemical device (for example, a capacitor, a primary battery, a secondary battery, or the like) under abnormal conditions such as nailing penetration.

Abstract: The present disclosure relates to a method and system for determining a final location associated with a service requester. The method includes obtaining, by at least one computer server of an online transportation service platform, an initial location associated with a service requester; comparing, by the at least one computer server, the initial location with a plurality of candidate locations in a database to generate at least one match result; and determining, by the at least one computer server, a final location based on the at least one match result, wherein the final location is associated with the initial location.

Abstract: An additive manufacturing device utilizing an electron beam and laser integrated scanning comprises: a vacuum generating chamber (1); a worktable means having a forming region at least provided in the vacuum generating chamber (1); a powder supply means configured to supply a powder to the forming region; an electron-beam emission focusing and scanning means (6) and an laser-beam emission focusing and scanning means (7) configured in such a manner that a scanning range of the electron-beam emission focusing and scanning means (6) and a scanning range of the laser-beam emission focusing and scanning means (7) cover at least a part of the forming region; and a controller configured to control the electron-beam emission focusing and scanning means (6) and the laser-beam emission focusing and scanning means (7) to perform a powder integrated-scanning and forming treatment on the forming region.

Abstract: Several embodiments provided for relate to methods of using of anti-CD19 CAR expressing immune cells in immunotherapy. Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: A neural network-based error compensation method for 3D printing includes: compensating an input model by a deformation network/inverse deformation network constructed and trained according to a 3D printing deformation function/inverse deformation function, and performing the 3D printing based on the compensated model. Training samples of the deformation network/inverse deformation network include to-be-printed model samples and printed model samples. The deformation network constructed according to the 3D printing deformation function is marked as a first network. During training of the first network, the to-be-printed model samples are used as real input models, and the printed model samples are used as real output models. The inverse deformation network constructed according to the 3D printing inverse deformation function is marked as a second network.

Abstract: A neural network-based error compensation method for 3D printing includes: compensating an input model by a deformation network/inverse deformation network constructed and trained according to a 3D printing deformation function/inverse deformation function, and performing the 3D printing based on the compensated model. Training samples of the deformation network/inverse deformation network include to-be-printed model samples and printed model samples. The deformation network constructed according to the 3D printing deformation function is marked as a first network. During training of the first network, the to-be-printed model samples are used as real input models, and the printed model samples are used as real output models. The inverse deformation network constructed according to the 3D printing inverse deformation function is marked as a second network.

Abstract: The present invention relates to a battery, comprising a positive electrode plate, a separator and a negative electrode plate, wherein the positive electrode plate comprises a positive electrode current collector and at least two layers of positive active materials on at least one surface of the positive electrode current collector in which the underlying positive active material layer in contact with the positive electrode current collector comprises a first positive active material, a first polymer material, and a first conductive material and in which the upper positive active material layer comprises a second positive active material, a second polymer material, and a second conductive material and the first polymer material comprises an oil-dispersible polymer material having a solubility in NMP at 130° C. for 5 minutes, which is 30% or less of the solubility of PVDF under the same conditions. The battery exhibits good safety performance and improved electrical performance.

Abstract: This application discloses an electrode plate rolling apparatus and an electrode plate rolling method that are configured to roll an electrode plate. The electrode plate includes a coated region and an uncoated region. The electrode plate rolling apparatus includes a roller group, a heating part, and a cooling part. The heating part is configured to heat the electrode plate, and the cooling part is configured to cool the electrode plate. The heating part further includes an extension assembly, and the extension assembly can extend the uncoated region when the heating part heats the electrode plate. The electrode plate passes through the cooling part after passing through the heating part. The heating part and the cooling part are configured to reduce a difference between an extensibility parameter of the uncoated region and an extensibility parameter of the coated region.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.