Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A header attachment fixture and methods for its use are disclosed. The header attachment fixture includes two attachment pieces and a header support piece. Each of the two attachment pieces is respectively attached to a distinct one of the two window casement pieces. The header support piece is placed between and attached to each of the two attachment pieces. Each of the two attachment pieces has a fastener portion for attaching the attachment piece to a window casement piece, and a fixture for attaching the attachment piece to the header support piece. Accordingly, the fastener portion is substantially hidden from view outside the header support piece.

Abstract: The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.

Abstract: A pressure sensor includes a base having a high-pressure contact portion, and a diaphragm positioned over the base and having an external top surface opposite the base. The external top surface is defined within a closed perimeter and external side surfaces extend down from an entirety of the closed perimeter toward the base. A high-pressure contact portion of the diaphragm is aligned with and separated by a gap from the high-pressure contact portion of the base. A sensing element is coupled to the diaphragm and provides an output based on changes to the diaphragm. When a hydrostatic pressure load above a threshold value is applied to the entire external top surface and external side surfaces of the diaphragm, the hydrostatic pressure load causes the high-pressure contact portion of the diaphragm to contact the high-pressure contact portion of the base.

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A flexible input/output controller logic interfaces with existing input/output controllers (IOC's) in order to configure the amount of data sent to and received from the IOC's. The flexible I/O interface receives data from a component at a rate determined by the particular component. The flexible I/O interface then feeds the received data to a traditional I/O controller at a rate suitable for the I/O controller. Thus, the interface to the individual I/O controllers is maintained. The flexible I/O logic balances bandwidth between a plurality of individual I/O controllers in order to better utilize the overall system I/O bandwidth. In one embodiment, the I/O configuration managed by the flexible I/O logic is determined during system-build, while in another embodiment, the I/O configuration is set during system initialization.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Systems and methods for automatic reorganization of pick slot assignments in a warehouse are described. Replenishments of products from storage slots to pick slots are used to perform product relocation to new pick slots for active items, along with traditional relocation moves for inactive items to establish open pick slots. By use of replenishments, the blocking of product relocations to new pick slots due to order picking activity is reduced or eliminated, enabling product relocation for improved slotting to be performed during normal warehouse operations. A dynamic slotting method is described where each item is assigned to a zone having a designated set of slots and each item is replenished to any new slot, as compared to an originally assigned slot, in the zone as stock is depleted by picking. Inactive items may be proactively relocated to temporary slots to reduce or eliminate the blocking of relocations of active items.

Abstract: A pressure sensor includes a base having a high-pressure contact portion, and a diaphragm positioned over the base and having an external top surface opposite the base. The external top surface is defined within a closed perimeter and external side surfaces extend down from an entirety of the closed perimeter toward the base. A high-pressure contact portion of the diaphragm is aligned with and separated by a gap from the high-pressure contact portion of the base. A sensing element is coupled to the diaphragm and provides an output based on changes to the diaphragm. When a hydrostatic pressure load above a threshold value is applied to the entire external top surface and external side surfaces of the diaphragm, the hydrostatic pressure load causes the high-pressure contact portion of the diaphragm to contact the high-pressure contact portion of the base.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

Abstract: The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A classification-based medical image segmentation apparatus includes an ultrasound image acquisition device configured for acquiring, from ultrasound, an image depicting a medical instrument such as needle; and machine-learning-based-classification circuitry configured for using machine-learning-based-classification to, dynamically responsive to the acquiring, segment the instrument by operating on information (212) derived from the image. The segmenting can be accomplished via statistical boosting (220) of parameters of wavelet features. Each pixel (216) of the image is identified as “needle” or “background.” The whole process of acquiring an image, segmenting the needle, and displaying an image with a visually enhanced and artifact-free needle-only overlay may be performed automatically and without the need for user intervention.

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A toothbrush having a first end and a second end with a plurality of picks in removeable communication with the second end, and a floss cutter configured to cut dental floss. The toothbrush has a body with a first side and a second side, the body comprising a hollow interior, wherein at least at least one plastic stud is configured to engage at least one sleeve, wherein dental floss is wrapped around the at least one sleeve. The dental floss extends from the at least one sleeve through the floss cutter, wherein the body and wherein the first end and the second end are in communication with the first side of the body.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Systems and methods for cookware detection are provided. One example system includes a vision sensor positioned so as to collect imagery depicting a cooktop. The system includes one or more processors and one or more non-transitory computer-readable media storing instructions that, when executed by the one or more processors, cause the one or more processors to perform operations. The operations include obtaining a frame of imagery depicting the cooktop and using a classifier to classify the frame of imagery as either depicting cookware or not depicting cookware. When the frame is classified as depicting cookware, the operations include performing one or more operations in response to the detected cookware.