Abstract: A toothbrush with a brush end, a floss end with a locking device, and a handle with a hollow interior. Within the hollow interior is at least one sleeve, at least one rod configured to matingly engage the at least one bearing sleeve, wherein floss is wrapped around the at least one bearing sleeve, and a floss channel configured to guide the floss from the at least one bearing sleeve to the floss end, wherein the locking device is configured to hold the dental floss across the floss end, and wherein the brush end and the floss end are in communication with the handle.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: A differential pressure sensor for sensing a differential pressure of a process fluid, includes a sensor body having a sensor cavity formed therein with a cavity profile. A diaphragm in the sensor cavity deflects in response to an applied differential pressure. The diaphragm has a diaphragm profile. A gap formed between the cavity profile and the diaphragm profile changes as a function of the differential pressure. At least one of the cavity profile and diaphragm profile changes as a function of a line pressure to compensate for changes in the gap due to deformation of the sensor body from the line pressure.

Abstract: The present inventors devised, among other things, systems, methods, and software that radically simplify and reduce the time necessary to specify, design, manufacture, and document control panels and wiring harnesses for semi-custom and custom equipment, such as HV AC equipment. A computer storage medium includes data relating to a plurality of control panel enclosures and a set of rules for designing a control panel. The system receives a selection of two or more components for placement in the control panel, retrieves information about the two or more components from a database, and generates one or more layouts. The one or more layouts comprise placement of the two or more components within at least one of the plurality of control panel enclosures as a function of the set of rules for designing a control panel. The control panel enclosures are dynamically selected as a function of the two or more components.

Abstract: A capacitance-based pressure sensor for measuring a process variable includes a metal sensor body, a diaphragm disposed within a cavity of the metal sensor to form a deflectable capacitor plate, and an insulator extending through the metal sensor body from an end wall to the cavity. The pressure sensor further includes an isolation tube in fluid connection with the cavity, the isolation tube extending into the insulator through the end wall, a stationary capacitor plate on a surface of the insulator in the cavity, the stationary capacitor plate spaced from the diaphragm, and an electrical lead wire connected to the stationary capacitor plate and extending through the insulator parallel to the isolation tube and exiting the insulator at the end wall. A fill fluid is within the isolation tube and the cavity to apply pressure to the diaphragm.

Abstract: A glove provides high palm shear force and reduced finger shear force when pulling elongated articles such as a rope, a rod, and the like. A high COF material is applied to palm and a low COF material is applied to inner finger surfaces. The fingers are still used to grasp the elongated article, but the shear pulling force on the fingers is reduced and the shear pulling force on the palm is increased. In one embodiment, the underlying glove material on the palm and finger grasping surfaces is a synthetic leather material, the high COF material on the palm is a silicone rubber material deposited on the synthetic leather material and the low COF material on the inner finger surfaces is a ballistic material sewn onto the synthetic leather material, for example, an aramid fiber material sold under the trademark Kevlar®.

Abstract: The present subject matter relates energy management systems and methodologies wherein control over local appliances is implemented to control stress on a local transformer to which a plurality of user locations may be connected. Some of the user locations are provided with home energy management (HEM) devices that control operation of certain appliance at their location based in part on constraints associated with the local transformer. The HEMs may negotiate among themselves how to meet the constraints of the local transformer and, in certain circumstances, take into consideration estimates of usage at user locations connected to the local transformer but that do not have their own HEM.

Abstract: A process variable transmitter for sensing a process variable of an industrial process includes a process variable sensor configured to sense a current process variable of the industrial process. Measurement circuitry is configured to compensate the sensed process variable as a function of at least one previously sensed process variable characterized by a Hysteron basis function model. Output circuitry provides a transmitter output related to the compensated sensed process variable.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Systems and methods for cookware detection are provided. One example system includes a vision sensor positioned so as to collect imagery depicting a cooktop. The system includes one or more processors and one or more non-transitory computer-readable media storing instructions that, when executed by the one or more processors, cause the one or more processors to perform operations. The operations include obtaining a frame of imagery depicting the cooktop and using a classifier to classify the frame of imagery as either depicting cookware or not depicting cookware.

Abstract: A differential pressure sensor for sensing a differential pressure of a process fluid, includes a sensor body having a sensor cavity formed therein with a cavity profile. A diaphragm in the sensor cavity deflects in response to an applied differential pressure. The diaphragm has a diaphragm profile. A gap formed between the cavity profile and the diaphragm profile changes as a function of the differential pressure. At least one of the cavity profile and diaphragm profile changes as a function of a line pressure to compensate for changes in the gap due to deformation of the sensor body from the line pressure.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Systems and methods for automatic reorganization of pick slot assignments in a warehouse are described. Replenishments of products from storage slots to pick slots are used to perform product relocation to new pick slots for active items, along with traditional relocation moves for inactive items to establish open pick slots. By use of replenishments, the blocking of product relocations to new pick slots due to order picking activity is reduced or eliminated, enabling product relocation for improved slotting to be performed during normal warehouse operations. A dynamic slotting method is described where each item is assigned to a zone having a designated set of slots and each item is replenished to any new slot, as compared to an originally assigned slot, in the zone as stock is depleted by picking. Inactive items may be proactively relocated to temporary slots to reduce or eliminate the blocking of relocations of active items.

Abstract: Because a touch controller may not be capable of providing a signal to indicate when to provide audio feedback, a computing system may include a touch event detector that is located in a communication channel between a touch controller and a processing system (e.g., a processor and main memory of a computing system). The touch event detector may monitor the touch data as it is relayed from the touch controller to the processing system via a communication hub. Once the touch event detector identifies a relevant touch event (i.e., a touch event that should provide audio feedback to a user), the touch event detector transmits an instruction to an audio output device (e.g., a speaker) which then generates the audio feedback.

Abstract: Multiple users may interact with the multiple touch monitors simultaneously. For example, a point-of-sale (POS) system may include two touch monitors (e.g., one facing the cashier and another facing the customer) that are controlled by the same operating system. To provide audio feedback to both users, the operating system needs to know on which monitor the touch event occurred. However, because the operating system may use a shared coordinate region, it only knows that a touch event occurred within the region but not know on which monitor. As such, embodiments herein describe a filter module that identifies a specific location of a touch event within the shared coordinate region and maps that location to one of the touch monitors. Once the specific touch monitor is identified, the filter module sends an instruction that causes a speaker assigned to the identified touch monitor to output the audio feedback.