Abstract: The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

Abstract: A self-oscillating converter includes a power transistor coupled to a primary winding for controlling current flow in the primary winding, and a turn-on circuit configured to turn on the power transistor for maintaining oscillation in the self-oscillating converter. The self-oscillating converter also includes a turn-off circuit configured to turn off the power transistor to maintain an on-time of the power transistor at a pre-set value for power factor correction, and modulate the on-time of the power transistor to regulate the output current in the load device.

Abstract: A child's toy transformable between a book position and a ball position, including a pair of end covers which each have round outer surfaces and planar inner cover surfaces, and a plurality of disc-shaped pages that have opposed circular planar surfaces with viewable indicia thereon. At least one flexible hinge in operative connection with each end cover and each page. In the ball position, the planar inner cover surfaces are in opposed facing relation and the plurality of disc-shaped pages are in abutting sandwiched relation therebetween. A releasable clasp may be engaged to hold the covers and pages in the ball position so the toy is readily rollable, and the clasp may be released to transform the toy to the book position in which the end covers are disposed away from one another and pages are individually movable to view indicia thereon.

Abstract: The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Some embodiments include a handheld device with programmable physical buttons. The physical buttons may be configured to perform different actions based on an orientation of the handheld device. Dynamically mapping actions to physical buttons may be based on an orientation condition that measures any one of orientation state of the device, a current application state, a change in the orientation state, or current device status. The actions may be updated automatically based on the orientation condition.

Abstract: A self-oscillating converter includes a power transistor coupled to a primary winding for controlling current flow in the primary winding, and a turn-on circuit configured to turn on the power transistor for maintaining oscillation in the self-oscillating converter. The self-oscillating converter also includes a turn-off circuit configured to turn off the power transistor to maintain an on-time of the power transistor at a pre-set value for power factor correction, and modulate the on-time of the power transistor to regulate the output current in the load device.

Abstract: Aspects of the present disclosure include methods of producing nucleic acid libraries. In certain aspects, the methods include producing tagged primer extension products, and contacting aliquots of the tagged primer extension products with transposomes to produce tagged extension product fragments. The methods may further include sequencing the tagged extension products and tagged extension product fragments to determine the sequences of nucleic acids of interest. Also provided are compositions and kits that find use, e.g., in practicing embodiments of the methods.

Abstract: In one embodiment, a reversible anchoring device includes a base having a threaded shaft and an internal passage that extends through the base along a longitudinal direction of the base and a cap having a top surface, a bottom surface, a threaded circular opening formed in the bottom surface adapted to thread onto the threaded shaft of the base, and a suture opening that extends from the top surface of the cap to the threaded circular opening through which a suture can pass.

Abstract: Aspects of the present disclosure include methods of producing nucleic acid libraries. In certain aspects, the methods include producing tagged primer extension products, and contacting aliquots of the tagged primer extension products with transposomes to produce tagged extension product fragments. The methods may further include sequencing the tagged extension products and tagged extension product fragments to determine the sequences of nucleic acids of interest. Also provided are compositions and kits that find use, e.g., in practicing embodiments of the methods.

Abstract: Aspects of the present disclosure include methods of producing nucleic acid libraries. In certain aspects, the methods include producing tagged primer extension products, and contacting aliquots of the tagged primer extension products with transposomes to produce tagged extension product fragments. The methods may further include sequencing the tagged extension products and tagged extension product fragments to determine the sequences of nucleic acids of interest. Also provided are compositions and kits that find use, e.g., in practicing embodiments of the methods.

Abstract: Aspects of the present disclosure include methods of producing nucleic acid libraries. In certain aspects, the methods include producing tagged primer extension products, and contacting aliquots of the tagged primer extension products with transposomes to produce tagged extension product fragments. The methods may further include sequencing the tagged extension products and tagged extension product fragments to determine the sequences of nucleic acids of interest. Also provided are compositions and kits that find use, e.g., in practicing embodiments of the methods.

Abstract: In one embodiment, a reversible anchoring device includes a base having a threaded shaft and an internal passage that extends through the base along a longitudinal direction of the base and a cap having a top surface, a bottom surface, a threaded circular opening formed in the bottom surface adapted to thread onto the threaded shaft of the base, and a suture opening that extends from the top surface of the cap to the threaded circular opening through which a suture can pass.

Abstract: A method, computer program product, and/or system dynamically appends a Uniform Resource Identifier (URI) fragment identifier to a Uniform Resource Locator (URL). A web browser on a client device displays a webpage, and accesses the HyperText Markup Language (HTML) coding for the webpage. HTML identification attributes are detected for the content that is being rendered within the web browser. A URI fragment identifier corresponding to the HTML identification attribute that is being rendered at the top of the web browser window is determined and is appended to the end of the URL of the webpage that is displayed in the URL box of the web browser. Detection of the content that is being rendered at the top of the web browser window occurs responsive to a command to scroll to a new section of the webpage.

Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.

Abstract: Methods, apparatuses, and computer program products for dynamically determining a primary or slave assignment based on an order of cable connection between two devices are provided. Embodiments include detecting, by a first device, insertion of one end of a cable into a port of the first device; determining, by the first device, whether a power signal is received from the cable at the port of the first device; if the power signal is received, performing, by the first device, a data transfer operation over the cable as a slave device to a second device that is coupled to the other end of the cable; and if the power signal is not received, performing, by the first device, a data transfer operation over the cable as a primary device to the second device that is coupled to the other end of the cable.

Abstract: A connection system having at least one male engagement component configured to engage with a female engagement component. The male engagement component is configured to interact with the female engagement component so that when pressure is applied, the at least one male engagement component embeds into the material of the female engagement component and generates sufficient friction to lock the relative positioning of the two components in at least one direction.

Abstract: In a method for accessing and storing original content without an overlay of interruption content, a computer receives original content with an overlay of interruption content during an interruption period from a content provider. The computer receives a notification that the interruption period is complete. The computer accesses original content without the overlay of interruption content. The computer stores the original content without the overlay of interruption content.

Abstract: A SEPIC converter with over-voltage protection includes a high-side inductor that connects a node Vw to a node Vx. The node Vx is connected, in turn to ground by a power MOSFET. The node Vx is also connected to a node Vy by a first capacitor. The node Vy is connected to ground by a low-side inductor. A rectifier diode further connects the node Vy and a node Vout and an output capacitor is connected between the node Vout and ground. A PWM control circuit is connected to drive the power MOSFET. An over-voltage protection MOSFET connects an input supply to the PWM control circuit and the node Vw. A comparator monitors the voltage of the input supply. If that voltage exceeds a predetermined value Vref the comparator output causes the over-voltage protection MOSFET to disconnect the node Vw and the PWM control circuit from the input supply.

Abstract: In a method for accessing and storing original content without an overlay of interruption content, a computer receives original content with an overlay of interruption content during an interruption period from a content provider. The computer receives a notification that the interruption period is complete. The computer accesses original content without the overlay of interruption content. The computer stores the original content without the overlay of interruption content.