Abstract: This invention relates to the use of an MC4 receptor agonist compound for the manufacture of a medicament for the treatment of lower urinary tract dysfunction.

Abstract: A mica-based electrically-conductive filler and reinforcing material, and methods of producing it. The material comprises milled mica particles and an electrically-conductive media such as carbon black or silver or copper adhered to the mica by a binder system. The material contributes both electrical conductivity and improved physical properties such as increased stiffness, increased tensile strength, and increased scratch resistance to materials for antistatic and electromagnetic shielding such as thermoplastic and thermosetting polymers, in a cost-effective manner relative to alternative prior art electrically-conductive and reinforcing materials.

Abstract: A balloon is connected to a cylindrical tube, and the resulting assembly is mounted on a container to serve as a decorative balloon display system.

Abstract: A card deck, according to the present invention comprises a 51 card set of double sided individual cards comprising 48 symbol cards and three timer cards. Each symbol card comprises a first symbol side and a second symbol side. The symbols may be any symbol, such as numbers, suits, shapes and the like.

Abstract: Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 or SEQ ID NO: 5 and variants, fragments, homologues, analogues and derivatives thereof; (b) a polypeptide of SEQ ID NO: 2 and variants, fragments, homologues, analogues and derivatives thereof; (c) a polypeptide encoded by the cDNA of NCIMB 41110 and variants, fragments, homologues, analogues and derivatives thereof; or (d) a polypeptide which has at least 78% identity to (i) the polypeptide encoded by the polynucleotide of SEQ ID NO: 1 or SEQ ID NO: 5, (ii) the polypeptide of SEQ ID NO: 2, or (iii) the polypeptide encoded by the cDNA of NCIMB 41110. Such polypeptide sequences are, inter alia, useful in the prophylaxis and/or treatment of sexual dysfunction, in particular male erectile dysfunction (MED) or female sexual dysfunction (FSD), preferably female sexual arousal disorder (FSAD).

Abstract: An adjustable matching network is provided for a wireless communications device transmitting and receiving signals in multiple frequency bands via an antenna. The adjustable matching network selectively connecting the antenna to a select power amplifier corresponding to a selected transmit frequency band and automatically matching the impedance of the antenna to the select power amplifier. The adjustable matching network also selectively connecting the antenna to a select bandpass filter corresponding to a selected receive frequency band and automatically matching the impedance of the antenna to the select bandpass filter.

Abstract: A new machine control method and system for registering pre-produced webs into a converting line producing disposable absorbent articles such as diapers, pull-ups, feminine hygiene articles or a component thereof. The pre-produced webs can include a multiplicity of pre-produced objects spaced on the web at a pitch interval in the web direction. The pre-produced web being manipulated in order for the pre-produced object of the web to be registered in relation to a target position. The present invention includes five embodiments, where the first embodiment is expressed as a generic claim. The first embodiment includes a closed-loop feedback registration system; the second and third embodiments, in addition, include an open-loop feedforward control system; the fourth and fifth embodiments, in addition, include an automatic phasing system. In addition, the third embodiment uses a machine vision system to recognize any element of a complex pre-produced object (e.g., colorful graphics).

Abstract: A new machine control method and system for registering pro-produced webs into a converting line producing disposable absorbent articles such as diapers, pants, feminine hygiene articles or a component thereof. The pre-produced web can include a multiplicity of pre-produced objects spaced on the web at a pitch interval in the web direction. The pre-produced web being manipulated in order for the pre-produced object of the web to be registered in relation to a target position constant. The present invention includes three embodiments, where the first embodiment is expressed as a generic claim. The first embodiment includes a closed-loop feedback registration system; the second and third embodiments, in addition, include an open-loop feedforward phasing system. In addition, the third embodiment uses a machine vision system to recognize any element of a complex pre-produced object (e.g., colorful graphics).

Abstract: A transfer apparatus is provided for transferring a workpiece from a moving anvil to a moving carrier. The apparatus comprises: a support structure comprising a support member rotatable about a first axis, and a workpiece gripping structure mounted to the support structure comprising at least one workpiece gripping member having a workpiece-receiving surface. The gripping member is rotatable about a second axis substantially parallel to the first axis such that the gripping member is capable of being rotated about the second axis during transfer of a workpiece from the moving anvil to the workpiece-receiving surface. The workpiece gripping member is also rotatable about a third axis substantially transverse to the first and second axes so as to be capable of rotating the workpiece from a first angular position at the anvil to a second angular position.

Abstract: In embodiments of the invention, a system receives selections from a user based on a list of pre-defined monitoring categories and/or optionally receives custom category definitions from the user. The option for custom category definitions may be advantageous due to the flexibility provided to a system administrator or other user. In embodiments of the invention, the pre-defined and/or custom monitoring categories may be or include complex hierarchical behavior. Such an approach provides monitoring algorithms that can achieve improved accuracy compared to known methods. In embodiments of the invention, the order of computations used in resolving a monitoring category may be re-ordered, statically and/or dynamically, to improve the efficiency of monitoring operations.

Abstract: A custom-decorated giftwrap is made by feeding a folded sheet into a printer, while avoiding paper jams therein by holding together sheet portions of the sheet.

Abstract: Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 or SEQ ID NO: 5 and variants, fragments, homologues, analogues and derivatives thereof; (b) a polypeptide of SEQ ID NO: 2 and variants, fragments, homologues, analogues and derivatives thereof (c) a polypeptide encoded by the cDNA of NCIMB 41110 and variants, fragments, homologues, analogues and derivatives thereof; or (d) a polypeptide which has at least 78% identity to (i) the polypeptide encoded by the polynucleotide of SEQ ID NO: 1 or SEQ ID NO: 5, (ii) the polypeptide of SEQ ID NO: 2, or (iii) the polypeptide encoded by the cDNA of NCIMB 41110. Such polypeptide sequences are, inter alia, useful in the prophylaxis and/or treatment of sexual dysfunction, in particular male erectile dysfunction (MED) or female sexual dysfunction (FSD), preferably female sexual arousal disorder (FSAD).

Abstract: The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A.

Abstract: Prophylactic treatment to reduce the incidence of common cold using formulations of zinc compounds with selected amino acids is described. The administration of such formulations to healthy individuals resulted in a statistically significant reduction in the incidence of common colds in healthy patients.

Abstract: The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5a1, a component of which is presented as SEQ ID No 1. The identified target sequence of the present invention may be used to as a target to identify agents (such as modulators) useful in the prevention and/or treatment of a disease associated with scarring and/or fibrosis or to selectively identify smooth muscle cells and myofibroblasts and myoepithelial cells in samples of normal and diseased tissue from individuals.

Abstract: An object, such as a foil balloon, is formed directly on a carrier and is manufactured while remaining on the carrier during subsequent heat sealing, die cutting, scrap removal, sheeting and printing operations.