Patents by Inventor Charles S. Zuker

Charles S. Zuker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACIDS ENCODING T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20110014634
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: May 3, 2010
    Publication date: January 20, 2011
    Applicants: The Regents of the University of California, Health and Human Services
    Inventors: Charles S. Zuker, Joh Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • In vitro method for identifying a compound using an eukaryotic mechanosensory transduction channel
    Patent number: 7867721
    Abstract: The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: January 11, 2011
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Richard G. Walker, Aarron Willingham
  • Nucleic acids encoding T2R taste receptors
    Patent number: 7868150
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: January 11, 2011
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
    Patent number: 7863433
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: January 4, 2011
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon Elliot Adler, Juergen Lindemeier
  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 7842786
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: November 30, 2010
    Assignees: Regents of the University of California, United States of America, NIH
    Inventors: Charles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Gregory A Nelson
  • Nucleic acids encoding T2R, a novel family of taste receptors
    Patent number: 7745601
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: June 29, 2010
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Assays for sensory modulators using a sensory cell specific G-protein alpha subunit
    Patent number: 7727729
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: June 1, 2010
    Assignee: The Regents Of The University Of California
    Inventor: Charles S. Zuker
  • T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20100062456
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: August 20, 2009
    Publication date: March 11, 2010
    Applicants: The Regents of the University of California, The Government of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • SF, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20090280506
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: October 23, 2007
    Publication date: November 12, 2009
    Applicants: The Regents of the University of California, of Health and Human Services National Institutes of Health Office of Technology Transfer
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Mammalian sweet and amino acid heterodimeric taste receptors
    Patent number: 7588900
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: September 15, 2009
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Greg Nelson
  • Mammalian T1R3 Sweet Taste Receptors
    Publication number: 20090155819
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: October 23, 2008
    Publication date: June 18, 2009
    Inventors: Isolde Erlenbach, Nicholas J.P. Ryba, Grace Zhao, Charles S. Zuker
  • NUCLEIC ACIDS ENCODING A G-PROTEIN COUPLED RECEPTOR INVOLVED IN TASTE TRANSDUCTION
    Publication number: 20090148948
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Application
    Filed: November 6, 2008
    Publication date: June 11, 2009
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier, Nick Ryba, Mark Hoon
  • Nucleic Acids Encoding Proteins Involved in Sensory Transduction
    Publication number: 20090104703
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific polypeptides, antibodies to such polypeptides, methods of detecting such nucleic acids and polypeptides, and methods of screening for modulators of sensory cell specific polypeptides.
    Type: Application
    Filed: December 2, 2008
    Publication date: April 23, 2009
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier, David Cowan
  • MAMMALIAN SWEET TASTE RECEPTORS
    Publication number: 20090098580
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Application
    Filed: June 26, 2008
    Publication date: April 16, 2009
    Inventors: Charles S. Zuker, Nicholas J.P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian sweet taste receptors t1r3
    Patent number: 7507793
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: March 24, 2009
    Assignees: The Regents of the University of California, United States of America Dept. of Health and Human Services National Institutes of Health-OTT
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Eukaryotic mechanosensory transduction channel
    Publication number: 20090075294
    Abstract: The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
    Type: Application
    Filed: February 6, 2007
    Publication date: March 19, 2009
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Richard G. Walker, Aarron Willingham
  • T2R, a novel family of taste receptors
    Publication number: 20090068733
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: October 19, 2007
    Publication date: March 12, 2009
    Applicants: The Regents of the University of California, Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Method for identifying compounds modulating taste transduction
    Patent number: 7479373
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: January 20, 2009
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Mammalian Sweet And Amino Acid Heterodimeric Taste Receptors
    Publication number: 20080318251
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: May 15, 2008
    Publication date: December 25, 2008
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
  • Method for screening taste-modulating compounds
    Patent number: 7465550
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: December 16, 2008
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon Elliot Adler, Nicholas J.P. Ryba, Ken Mueller, Mark Hoon