Patents by Inventor Charles S. Zuker

Charles S. Zuker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian T1R3 sweet taste receptors
    Patent number: 7459277
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: December 2, 2008
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Isolde Erlenbach, Nicholas J. P. Ryba, Grace Zhao, Charles S. Zuker
  • Nucleic acids encoding T2R of taste receptors
    Patent number: 7452694
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: November 18, 2008
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
    Publication number: 20080249293
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Application
    Filed: March 8, 2007
    Publication date: October 9, 2008
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • ASSAYS FOR SENSORY MODULATORS USING A SENSORY CELL SPECIFIC G-PROTEIN ALPHA SUBUNIT
    Publication number: 20080206785
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
    Type: Application
    Filed: January 15, 2008
    Publication date: August 28, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Charles S. Zuker
  • Mammalian sweet taste receptors
    Patent number: 7402400
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: July 22, 2008
    Assignees: Regents of the University of California, The United States of America Department of Health and Human Services
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Assays for sensory modulators using a sensory cell specific G-protein alpha subunit
    Patent number: 7335479
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: February 26, 2008
    Assignee: The Regents of the University of California
    Inventor: Charles S. Zuker
  • Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
    Patent number: 7282557
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: October 16, 2007
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
    Patent number: 7270967
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: September 18, 2007
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • T2R, a novel family of taste receptors
    Patent number: 7244584
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: July 17, 2007
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller
  • Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets
    Patent number: 7087388
    Abstract: The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: August 8, 2006
    Assignee: Aurora Biosciences Corporation
    Inventors: Charles S. Zuker, John D. Mendlein, Yumei Sun, Susan Tsunoda, Jimena Sierralta
  • Assays for sensory modulators using a sensory cell specific G-protein beta subunit
    Patent number: 6929925
    Abstract: The invention identifies nucleic acid and amino acid sequences of sensory specific G-protein beta subunits that are specifically expressed in sensory cells, antibodies to such subunits, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific beta subunits.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: August 16, 2005
    Assignee: The Regents of The University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • Assays for sensory modulators using a sensory cell specific G-protein alpha subunit
    Patent number: 6875574
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: April 5, 2005
    Assignee: The Regents of the University of California
    Inventor: Charles S. Zuker
  • Assays for sensory modulators using a sensory cell specific phospholipase C
    Patent number: 6815176
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific phospholipase C that are specifically expressed in taste cells, antibodies to such phospholipase C, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific phospholipase C.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: November 9, 2004
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • T2R, a novel family of taste receptors
    Publication number: 20040038312
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: February 10, 2003
    Publication date: February 26, 2004
    Inventors: Charles S. Zuker, John Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Nucleic acids encoding a G protein gamma subunit involved in sensory transduction
    Patent number: 6623939
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of a sensory cell specific G protein gamma subunit, antibodies to such subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of sensory cell G protein gamma subunits.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: September 23, 2003
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, David M. Cowan
  • Mammalian sweet and amino acid heterodimeric taste receptors
    Publication number: 20030166137
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: July 3, 2002
    Publication date: September 4, 2003
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
  • SF, a novel family of taste receptors
    Publication number: 20030157568
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: March 7, 2003
    Publication date: August 21, 2003
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Eukaryotic mechanosensory transduction channel
    Publication number: 20030152991
    Abstract: The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
    Type: Application
    Filed: February 18, 2003
    Publication date: August 14, 2003
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Richard G. Walker, Aarron Willingham
  • SF, a novel family of taste receptors
    Patent number: 6558910
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: May 6, 2003
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller
  • Eukaryotic mechanosensory transduction channel
    Patent number: 6537778
    Abstract: The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: March 25, 2003
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Richard G. Walker, Aarron Willingham