Abstract: Disclosed herein are methods of producing tumor antigen-specific T cells and uses thereof. In the present method, peripheral blood mononuclear cells (PBMCs) isolated from a subject are cultivated with bi-specific antibodies (BsAbs) in a culture medium so as to produce the tumor antigen-specific T cells from the PBMCs. Also provided in the present disclosure are tumor antigen-specific T cells produced by the present method, and uses thereof in treating subjects suffering from cancers.

Abstract: Embodiments relate to combinations, assemblies, and methods of assembly of a reusable absorbent carrier insert and disposable insert combination comprising a reusable absorbent carrier insert and a disposable insert. The reusable absorbent carrier insert comprises a carrier portion and has a first capacity-to-caliper ratio. The disposable insert comprises an absorbent material and has a second capacity-to-caliper ratio. The disposable insert is configured to be received and contained within the carrier portion of the reusable absorbent carrier insert to form the reusable absorbent carrier insert and disposable insert combination. The first length is greater than the second length, the first width is greater than the second width, and the first capacity-to-caliper ratio is less than the second capacity-to-caliper ratio.

Abstract: The present disclosure relates to a complex probiotic composition and a method for improving exercise performance of a subject with low intrinsic aerobic exercise capacity. The complex probiotic composition, which includes Lactobacillus rhamnosus GKLC1, Bifidobacterium lactis GKK24 and Clostridium butyricum GKB7, administered to the subject with the low intrinsic aerobic exercise capacity in a continuation period, can effectively reduce serum lactic acid and serum urea nitrogen after aerobic exercise, reduce proportion of offal fat and/or increase liver and muscle glycogen contents, thereby being as an effective ingredient for preparation of various compositions.

Abstract: The present disclosure discloses a damping device, a cooker and a device having a damping structure, wherein the damping device is arranged between a main body and a cover body, comprising a rotary member (2) fixed on the cover body; a fixed member (11) fixed on the main body, the fixed member (11) being a hollow body having openings at two ends, the rotary member (2) being nested in the hollow body, one of the rotary member (2) and an inner side wall of the hollow body being provided with a friction member (21), the other one being provided with an elastic piece (14); during the process of opening the cover body, the elastic piece (14) is slidably fitted with the friction member (21) and generates varying frictional resistance during sliding. The damping device is less susceptible to outside temperature and humidity and thus is less likely to fail.

Abstract: Provided herein is a disinfecting device including a container containing a chlorhexidine-based solution having a chlorhexidine concentration of from 0.2-2.0% wt/vol. Provided also is a medical connector disinfected with the disinfecting device. A method of disinfecting a medical connector using the disinfecting device is also disclosed.

Abstract: The present disclosure provides a method for improving bioavailability of an NAD+ derivative. The method improves the bioavailability of the NAD+derivative by arranging a CD38 inhibitor and the NAD+ derivative in a same preparation, and controlling the CD38 inhibitor to release first rapidly, and then the NAD+ derivative releases after the CD38 inhibitor has taken effect, thereby increasing the level of NAD+ in vivo.

Abstract: An internal rotor type nail drive device of electric nail gun, comprising a nailing rod and an internal rotor type rotary actuator that can output a specific rotation angle and can drive the nailing rod to move downward for nailing. Specifically, the rotary actuator comprises a stator and a rotor arranged inside the stator, even groups of electromagnetic mutual action components are configured in pairs between the stator and the rotor, to generate a tangential force to drive the rotor to rotate for a specific rotation angle, and to drive the nailing rod to move for a nailing stroke. The nailing stroke can be determined by a specific rotation angle. Thus, through the above configuration of the rotary actuator, the structure of the electric nail gun can be simplified, and the kinetic energy for nailing can be increased.

Abstract: The present disclosure provides a use of a pharmaceutical composition including adenine and/or a pharmaceutically acceptable salt thereof in a manufacture of a medicament for treating diabetic ulcers, and the medicament can effectively accelerate and enhance wound healing of diabetic ulcers and prevent scar formation.

Abstract: Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.

Abstract: The present disclosure relates to a surgical robot and a method of controlling the surgical robot. The method may include obtaining pose information of an end tool and providing first feedback information to an operator based on the pose information.

Abstract: Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e.g., CNS). In some embodiments, the BBB-crossing receptor is LRP6. Disclosed herein also include recombinant adeno-associated viruses (rAAVs) with increased specificity and transduction efficiency across the BBB and related compositions and methods of treating various diseases and conditions.

Abstract: An endo motor (200) and an endo motor (200) control method. The endo motor (200) comprises a root canal handle (220), a root canal file (230), an electric motor and a first near field communication device (240), wherein the electric motor and the root canal file (230) are both connected to the root canal handle (220); the electric motor is configured to drive the root canal file (230) to rotate; the first near field communication device (240) is electrically connected to the electric motor; and the first near field communication device (240) is configured to control the electric motor on the basis of external information (250).

Abstract: The present disclosure relates to a method for treating a cancer and/or cancer metastasis in a subject comprising administering to the subject irinotecan loaded in a mesoporous silica nanoparticle. The present disclosure also provides a conjugate comprising an agent loaded in a mesoporous silica nanoparticle (MSN) defining at least one pore and having at least one functional group on a sidewall of the at least one pore.

Abstract: The invention discloses an external roll cover for a pickup truck, including a layer of leather and a supporting frame, the layer of leather is connected to the cargo hopper through a supporting frame, the supporting frame includes a front rail assembly, a rear rail assembly and a side rail assembly, the front rail assembly is connected to the rear rail assembly through a side rail assembly, the front rail assembly includes a front rail, a front rail joint and a front rail rubber strip, the front rail is connected with the side rail assembly through a front rail joint, the front rail is connected with a front rail rubber strip, the front rail joints are connected at both ends of the front rail, the front rail rubber strip is stick on the bottom of the front rail. The front rail strip is very long, which can play a good waterproof effect.

Abstract: Disclosed are a multi-modality molecular imaging probe, and a preparation method and use thereof. The multi-modality molecular imaging probe has an ABA structure, with a magnetic functional unit of a gadolinium complex at the center, and two identical phosphorescent functional units of an iridium complex, which are reasonably integrated into the same one complex molecule. The multi-modality molecular imaging probe simultaneously introduces two optical functional units of the iridium complex and one magnetic functional unit of a gadolinium chelate in the same one complex molecule, which exhibits magnetic-optical dual functional properties. It therefore could be used to prepare both a contrast agent for magnetic resonance imaging and an optical probe for optical imaging.

Abstract: A vehicle cover, the vehicle cover comprises a top cover, a front cover, a rear cover, side covers disposed on two sides of the top cover, and a plurality of brace rods. Tops of inner walls of the side covers comprise plug pockets in which ends of the plurality of brace rods are disposed, ends of the plug pockets away from the top cover are open, the inner walls of the side covers comprise sleeving tubes, the plurality of brace rods are disposed in the plug pockets after passing through the sleeving tubes, tow strips are disposed on the plug pockets, and the inner walls of the side covers comprise flexible pull rings used for pulling the vehicle cover by external objects.

Abstract: Systems, methods and compositions provided herein relate to the preparation of nucleic acid libraries. Some embodiments include the preparation of nucleic acid libraries by ligation of single-stranded nucleic acids.

Abstract: Microneedle arrays provided herein enable a minimally invasive platform for ocular drug delivery. Such a design and manufacture technique includes a conformable preformed interlocking mechanism configured about an elongated structure wherein the conformable preformed interlocking mechanism is arranged with a width that decreases in the needle tip direction and decreases in the base direction; and wherein each of the microneedles to include the conformable preformed interlocking mechanism is arranged to increase in area upon fluid tissue contact and decrease in area upon illumination with light.

Abstract: A method for preparing bio-active particles by spray drying, liquid nitrogen quick-freezing, and vacuum freeze drying includes the following steps: transporting a feed liquid into a preheated spray tower, wherein the feed liquid forms liquid droplets after being atomized by an atomizer in the spray tower, dispersing air is introduced into a top of the spray tower, and the dispersing air disperses the atomized liquid droplets; introducing hot air into the top of the spray tower, wherein the liquid droplets are partially formed into dry-like particles after being dried by the hot air, the surface dried particles fall, through a bottom of the spray tower, into a cooling pool arranged under the spray tower, and the particles, after being frozen, are transferred to a freeze drying device for freeze drying.

Abstract: A sensor device may include a substrate within the housing, a sensing element coupled to the substrate, and a shielding element surrounding the sensing element, wherein the shielding element extends through an opening of the substrate. The sensor device may further include a busbar extending through the housing, wherein the shielding element further extends through an indentation along at least one side of the busbar.