Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.

Abstract: The present disclosure provides a superhydrophobic and self-cleaning anticoagulant composite coating material and a preparation method and use thereof, and relates to the technical field of biomedical materials. In the coating material provided by the present disclosure, a titanium dioxide nanotube-based structure increases microscopic roughness of a surface of a titanium-based metal substrate, and a hydrophobic modification layer reduces surface energy of the material. The rough structure and the hydrophobic modification layer have a synergistic effect to construct a superhydrophobic surface, making the surface of the material have self-cleaning characteristics and low adhesion. Air can be retained on the surface of the material to form an air layer, thereby reducing the contact area between the material and bacteria and platelets in the blood, and inhibiting adhesion of the bacteria, platelets, and plasma proteins to the material.

Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: The present disclosure discloses a preparation method of an aluminum nitride (AlN) composite structure based on a two-dimensional (2D) crystal transition layer. The preparation method of the present disclosure includes: transferring the 2D crystal transition layer on a first periodic groove of an epitaxial substrate; forming a second periodic groove staggered with the first periodic groove on the 2D crystal transition layer; depositing a supporting protective layer; depositing a functional layer of a required AlN-based material; and removing the 2D crystal transition layer through thermal oxidation to obtain a semi-suspended AlN composite structure. The preparation method of the present disclosure has low difficulty and is suitable for large-scale industrial production.

Abstract: An overhead hoist transfer apparatus includes a rail assembly including a straight rail having an empty section, and a curved rail having a curved empty section; an engine including a first LSD having first and second wheels at two sides respectively; and a second LSD having third and fourth wheels at two sides respectively; a moving carriage driven by the engine and suspended from the rail assembly; first and second guide wheels disposed on the first LSD; third and fourth guide wheels disposed on the second LSD; and two guide boards disposed above a joining point of the straight rail and the curved rail. An elevation of the guide boards is equal to that of the guide wheels. The guide board includes a straight edge and a curved edge.

Abstract: A method for installing brackets includes: triggering a robotic arm to retrieve a fastener; and scanning a first image captured by a camera defining a view of a location of a bracket for features of a strut channel. The method also includes, in response to detecting features of the strut channel: maneuvering the end effector to locate the fastener over the strut channel based on the strut channel pose; and driving the end effector to couple the fastener within the strut channel. The method further includes: triggering the end effector to retrieve the bracket; and scanning a second image captured at the optical sensor for features of the fastener. The method also includes, in response to detecting features of the fastener: maneuvering the end effector to locate the bracket over the fastener based on the fastener pose; and driving the end effector to couple the bracket to the fastener.

Abstract: A can opener and a control method thereof. The can opener comprises a support, a pushing wheel, a can opening cutter, and a cutter shaft; the pushing wheel is rotatably provided on the support by taking a central shaft of the pushing wheel as the center; a first position limiting member is provided on the outer wall of the cutter shaft; the can opening cutter is rotatably sleeved on the cutter shaft and is located on the first position limiting member; a gap exists between the can opening cutter and the support; a cutter edge is provided on the peripheral wall of the can opening cutter; a second position limiting member spaced from the cutter edge is further provided on the peripheral wall of the can opening cutter close to a first end of the pushing wheel; and a gap is formed between the cutter edge and the pushing wheel.

Abstract: In a tire pressure adjustment method, an adjustment device in a vehicle obtains a first distance between the vehicle and a target object in front of the vehicle in a moving direction. The adjustment device determines a second distance that is a safe braking distance of the vehicle. When the first distance is less than the second distance, the adjustment device determines a tire pressure adjustment value of a tire of the vehicle based on the first distance and the second distance. The adjustment device determines a target voltage based on the tire pressure adjustment value, and adjusts a power supply voltage of a valve of the tire based on the target voltage. The valve exhausts air out of the tire after being powered on, and an exhaust velocity of the valve varies with different power supply voltages.

Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: The present disclosure provides an electric television bracket, which includes a fix seat; an installation rack, configured to install a television; a connector, where one end thereof is fixed to the fix seat and the other end thereof is connected to the installation rack through a first pivot; a connection mechanism, where one end thereof is connected to the installation rack through a second pivot and the other end thereof is connected to the fix seat through a third pivot; and a drive unit, where a first end thereof is rotatably connected to the installation rack and a second end thereof is rotatably connected to the fix seat; and a distance between the first pivot and the second pivot is at least one-third of a length of the installation rack.

Abstract: Techniques are described for identifying a genetic variant in a test sample by comparing sequences reads obtained from the test sample to unique k-mers that are representative of a target genomic region. In one particular aspect, a method is described that includes generating a dictionary of a target genomic region having a set of unique k-mers by: accessing a sequence of the target genomic region, determining a set of k-mers for the target genomic region, comparing the set of k-mers for the target genomic region with one or more sets of k-mers for non-target genomic regions, and selecting the unique k-mers that do not appear in the one or more sets of k-mers for non-target genomic regions. The dictionary can then be used to identify a genetic variant in a test sample by comparing sequences reads obtained from the test sample to the unique k-mers in the dictionary.

Abstract: A method for preparing a tumor-derived microparticle by a microwave includes the following steps: step 1, Lewis lung carcinoma (LLC) of a lung adenocarcinoma cell line is taken and then the LCC is cultured in a culture dish for more than 24 hours (h) to obtain cultured cells; step 2, microwave heating treatment is performed on the cultured cells obtained in step 1 to obtain treated cells; step 3, the treated cells obtained in step 2 are placed into a constant temperature incubator for cultivation for 24 h; and step 4, a supernatant of cells is collected from the culture dish cultured in step 3, and multiple centrifugation treatments is performed on the supernatant by using a density gradient centrifugation method to obtain a precipitate which is the tumor-derived microparticle TMPMW.

Abstract: A method for smelting low-phosphorus high-manganese steel based on reduction dephosphorization of ferromanganese is provided in the present application, relating to the technical field of high-manganese steel smelting, where the dephosphorization of ferromanganese is carried out under reducing atmosphere conditions through mediate-frequency induction furnace to obtain molten ferromanganese with lower phosphorus content, which is subsequently mixed with low phosphorus molten steel obtained by smelting in oxidative period of electric arc furnace in LF ladle refining furnace to make the Mn content of steel reach the requirement of high-manganese steel, and smelting is carried out under the condition of reducing atmosphere by adjusting the composition and temperature of the molten steel to meet the requirements of the target composition of the steel grade before tapping the steel.

Abstract: An imine reductase mutant, including a mutation in an amino acid sequence represented by SEQ ID NO: 1. The mutation in the amino acid sequence includes V171, A172, Y230, or a combination thereof. Also provided is a method for preparing (S)-nicotine, including: under suitable conditions, catalytically reducing a substrate I to (S)-nornicotine by the imine reductase mutant, and methylating (S)-nornicotine to yield (S)-nicotine.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: The present disclosure relates to air assemblies having an inflation, a deflation, and a closed state for use with inflatable products, such as air mattresses. Specifically, the present disclosure relates to air assemblies where the configuration of the air assembly can be changed manually by a user by operating a directional control valve to inflate, deflate, or close the inflatable product. The directional control valve may also activate a pump in the inflation and deflation states and deactivate the pump in the closed state.

Abstract: Provided are a series of 5,6-dihydrothieno[3,4-h]quinazoline compounds as represented by formula (P) and pharmaceutically acceptable salts thereof, and the use of the compounds or pharmaceutically acceptable salts thereof in the preparation of solid tumor drugs, such as solid tumor drugs associated with selective PLK1 inhibitors.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: Anthraquinone-based covalent organic frameworks; methods for preparing anthraquinone-based covalent organic frameworks; solid electrolyte interphases including the anthraquinone-based covalent organic frameworks; and electrochemical devices including the solid electrolyte interphases. The solid electrolyte interphases can exhibit enhanced transport of Li+. Battery cells including the solid electrolyte interphase exhibit improved reversible capacities.

Abstract: A light emitting device and a light source module are provided. The light emitting device includes a base, a conductive unit, a light unit, and a package. The base includes a first substrate and n through holes, and the through holes pass through the first substrate. The conductive unit includes m conductors that are separate from each other, and the conductors pass through the first substrate. The light unit is electrically connected to the conductors. The package includes a first package body surrounding the light unit and a second package body covering the light unit and the first package body. The first package body and the second package body have different optical properties. Furthermore, m and n are integers greater than or equal to 2, and m is greater than or equal to n.