Publication number: 20260091081
Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Type:
Application
Filed:
October 8, 2025
Publication date:
April 2, 2026
Applicant:
HANGZHOU DAC BIOTECH CO., LTD
Inventors:
Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Huihui GUO, Lu BAI, Wenjun LI, Junxiang JIA, Zhixiang GUO, Jun ZHENG, Xiaoxiao CHEN, Xiangfei KONG, Chen LIN, Yong DU, Yu ZHANG, Lei ZHOU, Xiuzhen ZHANG, Xiuhong ZHENG, Binbin CHEN, Yanlei YANG, Meng DAI, Yifang XU, Zhongliang FAN, Xiaomai ZHOU, Xingyan JIANG, Miaomiao CHEN, Lingli ZHANG, Yanhua LI
Patent number: 12576124
Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Type:
Grant
Filed:
February 18, 2020
Date of Patent:
March 17, 2026
Assignee:
HANGZHOU DAC BIOTECH CO., LTD
Inventors:
Robert Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Hangbo Ye, Linyao Zhao, Huihui Guo, Lu Bai, Wenjun Li, Junxiang Jia, Zhixiang Guo, Jun Zheng, Xiaoxiao Chen, Xiangfei Kong, Chen Lin, Yong Du, Yu Zhang, Lei Zhou, Xiuzhen Zhang, Xiuhong Zheng, Binbin Chen, Yanlei Yang, Meng Dai, Yifang Xu, Zhongliang Fan, Xiaomai Zhou, Xingyan Jiang, Miaomiao Chen, Lingli Zhang, Yanhua Li