Abstract: The present disclosure relates, in part, to risankizumab compositions having a reduced level of hitchhiker protein PLA2, Poloxamer 188, and/or decreased immunogenicity.

Abstract: The invention discloses a polypeptide that specifically binding to CD123 protein, a polypeptide complex and a co-delivery system, and preparation methods and use thereof. The general formula of amino acid arrangement in the polypeptide is X1-DYDTR-X2-QGTD-X3-G-X4-DFRRISD-X5; it can bind to CD123-positive cells and inhibit the progression of leukemia; the polypeptide complex can increase the binding quantity of the polypeptide to CD123-positive cells, and drug can inhibit the progression of leukemia alone and prolong the survival of leukemia mice; the co-delivery system can load chemotherapy drugs for tumor treatment and reduce the toxicity of chemotherapy drugs to normal cells.

Abstract: Embodiments of the present disclosure provide techniques for mountless querying of listing data. A processing device obtains a query that includes a universal listing identifier of a database, wherein the universal listing identifier is different from an identifier for the database. The processing device activates, at runtime, at least one role for accessing the database and shared objects based on the universal listing identifier. The processing device generates, based on the universal listing identifier and the at least one activated role, an in-memory placeholder object associated with the database. The processing device provides access to data of the database based on the in-memory placeholder object and the query.

Abstract: Examples described herein provide systems and methods for mitigating hallucinations in artificial intelligence chatbots. Aspects include receiving a prompt from a user, generating, in response to the prompt, an output by a thought generator, where the thought generator is configured to utilize one or more large language models to generate the output, and calculating, by a thought assessor, a confidence score for the output. Aspects also include performing a supplemental review of the prompt and the output, where the supplemental review determines whether the output includes a hallucination, based on a determination that the confidence score of the output does not exceed a threshold value and based on a determination that the output includes the hallucination, fine-tuning the thought generator.

Abstract: A crossarm assembly includes: a fitting assembly; a first insulator having an end connected to the fitting assembly; a second insulator having an end connected to the fitting assembly, the second insulator being located below the first insulator; a first hinged member connected to another end of the first insulator, the first hinged member being configured to connect a tower body of a power transmission tower, and the first insulator being rotatable relative to the tower body of the power transmission tower; and a second hinged member connected to another end of the second insulator, the second hinged member being configured to connect the tower body of the power transmission tower, and the second insulator being rotatable relative to the tower body of the power transmission tower.

Abstract: Examples described herein provide systems and methods for enhancing artificial intelligence decision-making with self-reflection and feedback mechanisms. Aspects include receiving a prompt from a user, generating, in response to the prompt, an output by a thought generator, where the thought generator is configured to utilize one or more large language models to generate the output, and calculating, by a thought assessor based at least on one or more historical self-reflection reports from an experience knowledgebase, a confidence score for an action specified in the output. Based on a determination that the confidence score of the output exceeds a threshold value, aspects include performing the action and observing an outcome of the action, generating a self-reflection report based on the prompt, the output, and the outcome, and storing the self-reflection report in the experience knowledgebase. Aspects further include fine-tuning the thought generator based on the outcome of the action.

Abstract: Provided in the present disclosure are an information processing method, a terminal and a storage medium. The information processing method includes: in response to an operation of sending a first message in a first conversation, displaying the first message in a conversation detail page of the first conversation, wherein the first conversation is not a topic group; in response to a topic creation operation for the first message in the first conversation, creating a first topic including the first message; and when there is a new message in the first topic, notifying members in the first conversation according to a preset notification policy, wherein in the preset notification policy, different notification policies are used according to different degrees of participation of different members in the first topic.

Abstract: The present invention provides an electroplating apparatus. A solid anode, a meshed anode or a perforated anode is arranged in the anode region to serve as an inert anode. And the constant distance is maintained between the inert anode and a substrate, so as to form a stable electric field on the surface of the substrate, thereby improving the uniformity of electroplating. An active anode is arranged below the inert anode in the anode region, so as to continuously replenish metal ions during the electroplating process, so that the metal ions can be more sufficiently conveyed to the substrate, thereby playing a role in improving the uniformity of electroplating. Components such as a rectifying plate, a fluid dispersion pipe or a stirring member are arranged in the anode region, so as to uniformly disperse the anode liquid, thereby further improving the uniformity of electroplating.

Abstract: The present disclosure discloses a use of a drug combination containing an anti-CD20 antibody drug conjugate (ADC) in the preparation of a drug for treating Non-Hodgkin Lymphoma (NHL). The drug combination includes the anti-CD20 ADC and at least one therapeutic agent. The drug combination therapy has better efficacy than the existing clinical first-line standard therapy. Additionally, it offers several advantages, including fewer types of drugs, shorter infusion time, lower safety risks, and better economic accessibility.

Abstract: The present disclosure relates, in part, to risankizumab compositions having a reduced level of hitchhiker protein PLA2, Poloxamer 188, and/or decreased immunogenicity.

Abstract: The present disclosure relates to a non-destructive in-situ measurement device and method based on Raman analysis. The device comprises: a laser light source that emits a laser beam; a focusing component that focuses the laser beam above a movable sample stage, with the focal plane of the focusing component positioned at an initial position. During measurement, the focal plane is controlled to move from the initial position to the surface, side, or bottom of the structure under test. The movable sample stage holds the sample to be measured and can move in a plane perpendicular and/or parallel to the optical axis. The axis of the structure under test is parallel to the optical axis and located within the laser beam's focal region. A detection module collects specific Raman scattering signals returned from the sample under test, and the structure's planar and three-dimensional parameters are determined based on the collected results.

Abstract: The present invention discloses a safe and efficient method for hypoxia-induced adipogenic differentiation of cells and use thereof, belonging to the technical field of cell culture. The method involves expanding cells to a certain number in a reactor in a suspension environment, and inducing adipogenic differentiation of the cells in suspension by reducing a dissolved oxygen level to hypoxia. The method induces adipogenic differentiation of cells solely through physical factors. Compared to traditional chemical induction adipogenic differentiation methods, no exogenous reagents are introduced during a differentiation process, and food safety is ensured. By using the method, cell adipogenic differentiation can be completed in 4-6 days, and expansion and adipogenic differentiation of cells can be completed in about 10 days, thus accelerating differentiation.

Abstract: Some embodiments of the present disclosure relate to material handling equipment, a controller and a pose detection method. The material handling equipment includes a controller, and the controller is configured to execute a program instruction to implement the following actions: acquiring a point cloud of a detection object provided with one or more reflective components; extracting, from the point cloud of the detection object, point clouds corresponding to the one or more reflective components; determining a target plane region according to the point clouds corresponding to the one or more reflective components; and determining a pose of the detection object according to a pose of the target plane region. Compared with the prior art, the material handling equipment, the controller and the pose detection method provided by some embodiments of the present disclosure improve the universality, accuracy and efficiency of the detection object recognition in warehouse logistics.

Abstract: A cross arm assembly includes: at least one insulator, an end of the at least one insulator being configured to be connected with a tower body of a transmission tower, forming a low-voltage end of the cross arm assembly, and another end of the at least one insulator being configured as an end of the cross arm assembly for hanging a conductor, forming a high-voltage end of the cross arm assembly; and a high-voltage end fitting, comprising a fixing portion, the high-voltage end fitting being configured to be connected with the other end of the at least one insulator and hang at least one conductor.

Abstract: Embodiments of this application provide a photographing method and an electronic device. The electronic device may recognize a capturing intention of a user, decide, based on a time of manual capture, a manually-captured highlight frame from image frames obtained within a short time before manual capture and image frames obtained within a short time after manual capture, for example, decide a manually-captured highlight frame from image frames obtained within 1 second before manual capture and image frames obtained within 5 seconds after manual capture. In addition, the electronic device may further search for an automatically-captured highlight frame based on a time of enabling auto capture. In this way, while an automatically-captured highlight photo is generated and a user triggers manual capture, the electronic device may store both the automatically-captured highlight photo and the manually-captured highlight.

Abstract: The present disclosure discloses a use of anti-CD20 ADC in the preparation of a drug for treating NHL, and the drug has excellent clinical efficacy and safety in treating a R/R NHL patient after receiving at least two standard treatments.

Abstract: Disclosed in the present invention are a polypeptide and a polypeptide composition specifically binding to a SARS-CoV-2 spike protein, and preparation methods and the uses thereof. By means of binding to S1 protein, the polypeptide and the polypeptide composition can block the binding of SARS-CoV-2 virus to a key target protein angiotensin-converting enzyme 2 (ACE2) protein on the surface of a host cell thereof, thereby providing a feasible targeting drug for the treatment of Coronavirus disease 2019.

Abstract: A metal-containing photoresist film may be deposited on a semiconductor substrate. Unintended metal-containing material may form on internal surfaces of a process chamber during deposition, bevel and backside cleaning, exposure, baking, development, etch, or other photolithography operations. A dry chamber clean may remove the unintended metal-containing material in multiple thermal steps. The dry chamber clean may remove some of the unintended metal-containing material by exposure to an etch gas such as a halide-containing gas. The remainder of the unintended metal-containing material may be removed by cycling between exposure to a modifying gas such as air and exposure to an etch gas.

Abstract: An embodiment of the present disclosure provides a plugin adding method and apparatus, an electronic device, and a storage medium. The method comprises: presenting a target page, wherein at least one plugin adding area is provided in the target page; receiving a plugin adding operation acting on the plugin adding area, and presenting a plugin editing area corresponding to the plugin adding operation; and receiving a plugin editing operation acting on the plugin editing area, generating a target plugin based on edited plugin information, and adding the target plugin to the plugin adding area.