Patents by Inventor Cheng Yao

Cheng Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200348257
    Abstract: A kit includes an array of charge sensors attached to a solid-phase substrate , wherein individual charge sensors in the array respectively comprise a channel and a polymerase and are located at different addressable locations on the solid-phase substrate; and a liquid comprising a plurality of different nucleic acids, each of the different nucleic acids including a unique label to be detected by a charge sensor of the array.
    Type: Application
    Filed: March 20, 2020
    Publication date: November 5, 2020
    Inventors: Boyan BOYANOV, Jeffrey G. MANDELL, Jingwei BAI, Kevin L. GUNDERSON, Cheng-Yao CHEN, Michel PERBOST
  • Patent number: 10787704
    Abstract: The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: September 29, 2020
    Assignees: ILLUMINA, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kevin L Gunderson, Jingwei Bai, Cheng-Yao Chen, Jeffrey G Mandell, Sergio Peisajovich, Philip G Collins, Gregory A Weiss, Boyan Boyanov
  • Patent number: 10767185
    Abstract: The present invention provides a preparation method for PCV2 capsid protein and a pharmaceutical composition containing said capsid protein. The method of the present invention uses a novel arabinose-induced expression vector and thereby improves the synthesis efficiency of said PCV2 capsid protein. On the other hand, the present pharmaceutical composition combines said capsid protein and other favorable components at a proper ratio so that achieves excellent immune-inducing effects.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: September 8, 2020
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Zeng-Weng Chen, Jyh-Perng Wang, Tzu-Ting Peng, Huei-Yu Lee, Weng-Zeng Huang, Shih-Rong Wang, Cheng-Yao Yang
  • Patent number: 10745751
    Abstract: Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3? sugar hydroxyl, as well as methods and kits using the same.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: August 18, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Erin Bomati, Molly He, Cheng-Yao Chen, Sergio Peisajovich
  • Publication number: 20200231948
    Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 23, 2020
    Inventors: Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
  • Patent number: 10696955
    Abstract: Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3? sugar hydroxyl, as well as methods and kits using the same.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: June 30, 2020
    Assignee: Illumina, Inc.
    Inventors: Erin Bomati, Michael Previte, Matthew William Kellinger, Cheng-Yao Chen, Molly He
  • Publication number: 20200181699
    Abstract: A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid.
    Type: Application
    Filed: December 5, 2019
    Publication date: June 11, 2020
    Inventors: Mostafa RONAGHI, Molly HE, Cheng-yao CHEN, Michael PREVITE, M. Shane BOWEN
  • Publication number: 20200169537
    Abstract: A system including a network communication device, a storage device, and a controller is provided. The storage device stores first mappings between IP addresses and devices, and second mappings between software and devices. The controller obtains a connection log from the proxy server or the firewall device via the network communication device, uses the first mappings and the second mappings to analyze the connection log to determine one or more different connections between connections of devices on which first software is installed and connections of devices on which the first software is not installed, determines whether the first software functions normally on a first device blocking the different connections, and adds destination addresses of the different connections into a blocking list in response to the first software functioning normally on the first device, such that the proxy server or the firewall device blocks all connections towards the destination addresses.
    Type: Application
    Filed: March 19, 2019
    Publication date: May 28, 2020
    Inventors: Chen-Chung LEE, Chia-Hung LIN, Cheng-Yao WANG, Jen-Hung CHANG, Ming-Jen CHEN
  • Publication number: 20200143369
    Abstract: A device for contracting smart contracts receives and stores event information provided by an organizer of an event and candidate information provided by a co-organizer candidate. The device for contracting smart contracts deploys a smart contract of the event in a block chain based on the event information, determines to assign the co-organizer candidate as a co-organizer of the event through the smart contract based on the candidate information, and records the candidate information into the smart contract to make the organizer contract with the co-organizer candidate.
    Type: Application
    Filed: December 4, 2018
    Publication date: May 7, 2020
    Inventors: Chih-Hsiang HU, Chen-Kuan TSAI, Cheng-Yao HO, Chi WULEE
  • Patent number: 10605766
    Abstract: A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: March 31, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Boyan Boyanov, Jeffrey G. Mandell, Jingwei Bai, Kevin L. Gunderson, Cheng-Yao Chen, Michel Perbost
  • Patent number: 10597642
    Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: March 24, 2020
    Assignee: Life Technologies Corporation
    Inventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
  • Publication number: 20200085747
    Abstract: A method for blood plasma protein activity preservation is provided. The method comprises the steps of mixing blood plasma with two or more protectants selected from the group consisting of triglyceride, glycerol, propylene glycol, alanine, serine, glycine, alginate, and sucrose to obtain a mixture; and lyophilizing the mixture.
    Type: Application
    Filed: December 21, 2016
    Publication date: March 19, 2020
    Inventors: Cheng-Yao SU, Chung Chin SUN, Shan Shue WANG
  • Patent number: 10570447
    Abstract: A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 25, 2020
    Assignee: Illumina, Inc.
    Inventors: Mostafa Ronaghi, Molly He, Cheng-yao Chen, Michael Previte, M. Shane Bowen
  • Publication number: 20200056230
    Abstract: Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3? sugar hydroxyl, as well as methods and kits using the same.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 20, 2020
    Applicant: ILLUMINA, INC.
    Inventors: Erin Bomati, Molly He, Cheng-Yao Chen, Sergio Peisajovich
  • Patent number: 10545115
    Abstract: A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: January 28, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Boyan Boyanov, Jeffrey G. Mandell, Jingwei Bai, Kevin L. Gunderson, Cheng-Yao Chen, Michel Perbost
  • Publication number: 20190376136
    Abstract: This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template.
    Type: Application
    Filed: March 13, 2019
    Publication date: December 12, 2019
    Inventors: Molly He, Cheng-Yao Chen, Eric Kool, Mostafa Ronaghi, Michael Previte, Rigo Pantoja
  • Publication number: 20190378392
    Abstract: A detection system and a detection method are provided. The detection system includes at least one illumination device and a host. The illumination device has a radar to obtain spatial information of a position of the illumination device. The host is connected to the at least one illumination device. The host receives the spatial information from the illumination device and transmits a change of the spatial information to an emergency system.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 12, 2019
    Applicant: HTC Corporation
    Inventors: Min-Chou Chuang, Lun-Kang Lin, Hsin-Cheng Yao, Chun-Yih Wu
  • Publication number: 20190335082
    Abstract: A video signal conversion device includes a front end interface, a rear end interface, a video detector and a video processor. The front end interface is coupled to a video source to receive an input signal. The rear end interface is coupled to a video receiver. The video detector determines whether the input signal corresponds to HDR imaging format. The video detector generates a conversion command in response to the input signal corresponding to HDR imaging format. The video processor is coupled to the front end interface, the rear end interface and the video detector. When the video processor receives the conversion command, the video processor converts the input signal into an output signal with SDR imaging format. The video processor sends the output signal to the video receiver via the rear end interface.
    Type: Application
    Filed: April 2, 2019
    Publication date: October 31, 2019
    Inventors: Wen-Chien CHANG, Yen-Cheng YAO
  • Publication number: 20190335138
    Abstract: A video signal conversion device includes a frontend interface circuit, a FPGA video processor and a backend interface circuit. The frontend interface circuit receives a HDR video input signal from a video transmitting device. The FPGA video processor outputs a SDR first video output signal. A video receiving device receives the first video output signal and a HDR second video output signal from the FPGA video processor through the video bridge controller of the backend interface circuit by PCI-E.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 31, 2019
    Inventors: Ssu-Ming Cheng, Hong-Wei Liu, Chen-Hsiang Wu, Shi-Jie Lin, Yen-Cheng Yao, Chih-Sheng Wang
  • Patent number: D898656
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: October 13, 2020
    Assignee: Human Horizons Holdings Co., Ltd.
    Inventors: Sherazee Riaz Ralf, Yu-Cheng Yao