Abstract: A biosensor for determining the concentration of an analyte in a biological sample. The biosensor comprises a support, a reference electrode or a counter electrode or both disposed on the support, a working electrode disposed on the support, the working electrode spaced apart from the other electrode or electrodes on the support, a covering layer defining a sample chamber over the electrodes, an aperture in the covering layer for receiving a sample, and at least one layer of mesh in the sample chamber between the covering layer and the electrodes. The at least one layer of mesh has coated thereon a silicone surfactant. Certain silicone surfactants are as effective as fluorinated surfactants with respect to performance of biosensors. These surfactants, when coated onto the mesh layer of the biosensor, are effective in facilitating the transport of aqueous test samples, such as blood, in the sample chamber.

Abstract: Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed.

Abstract: A method of analyzing a remotely-located object includes the step of illuminating at least a portion of a targeted object with electromagnetic radiation to induce a phase transformation in the targeted object, wherein the phase transformation produces an emitter plasma, which emits terahertz radiation. The method also includes the step of ionizing a volume of an ambient gas to produce a sensor plasma by focusing an optical probe beam in the volume and the step of detecting an optical component of resultant radiation produced from an interaction of the focused optical probe beam and the terahertz radiation in the sensor plasma. Detecting an optical component of the resultant radiation emitted by the sensor plasma facilitates detection of a characteristic fingerprint of the targeted object imposed onto the terahertz radiation produced as a result of the induced phase transformation.

Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: A method and system for imaging an object includes transmitting distinguishable electromagnetic waves from a plurality of radiators of an antenna array, wherein each of the distinguishable electromagnetic waves is distinguishable from others by a detector. Each of the radiators transmits radiation comprising a different distinguishable electromagnetic wave. The method also includes imaging at least a portion of the antenna array onto a targeted object, wherein each image area of a plurality of image areas on the targeted object corresponds to an image of a respective radiator of the antenna array, and detecting a plurality of resultant electromagnetic waves, wherein the resultant electromagnetic waves are transmitted, scattered, or reflected by respective image areas on the targeted object in response to each of the respective image areas being illuminated by the radiation transmitted by the respective radiator of the source array.

Abstract: A mounting apparatus for mounting two or more types of data storage devices that each defines a locking hole in a sidewall thereof includes a bracket for holding the data storage devices, a fixing member, and a locking member. The bracket includes a first side wall. The first side wall defines a locating hole therein. The locating hole has at least two locating positions. The fixing member is pivotably mounted to the first side wall of the bracket. The locking member is selectively mounted to at least two positions of the fixing member. The locking member includes a locking portion extending therefrom, for selectively being inserted through the at least two locating positions of the locating hole of the bracket to engage in the locking hole of a corresponding type of data storage device.

Abstract: Carbon nanostructures are formed from a carbon precursor and catalytic templating nanoparticles. Methods for manufacturing carbon nanostructures generally include (1) forming a precursor mixture that includes a carbon precursor and a plurality of catalytic templating particles, (2) carbonizing the precursor mixture to form an intermediate carbon material including carbon nanostructures, amorphous carbon, and catalytic metal, (3) purifying the intermediate carbon material by removing at least a portion of the amorphous carbon and optionally at least a portion of the catalytic metal, and (4) heat treating the purified intermediate carbon material and/or treating the purified intermediate carbon material with a base to remove functional groups on the surface thereof. The removal of functional groups increases the graphitic content of the carbon nanomaterial and decreases its; hydrophilicity.

Abstract: The present invention is an adhesive suitable for use in the production of engineered wood products, said adhesive comprised of an aromatic diisocyanate (99.0-10.0 parts by mass) and an aromatic petroleum distillate (1.0-90.0 parts by mass) with low volatility. The adhesive composition may result in improved coverage or distribution on the outer surface of raw materials, such as strands, particles, flakes, fibers, or veneer.

Abstract: The present invention is directed to a system and method which base stations send informational messages to neighbor base stations when conditions change, so that the neighbor base stations can update its database to keep itself current on the parameters (including availability, traffic load, modulation scheme, etc.) to use in effecting efficient base station to base station handoffs. In one embodiment, the receiving base station marks the time of the received message from a neighbor base station and if a new updated message is not received within a time window then the receiving base station assumes that there is a problem with that neighbor.

Abstract: A device and a method for distributing measurement sample and cleaning tubes, wherein the device comprises: a diluent container for accommodating a diluent therein; an aspirating tube for sucking a measurement sample; a first syringe driven by a power unit and used to quantify the measurement sample; a second syringe driven by the power unit and used to quantify the diluent; a first switching unit connected to the first syringe, the second syringe and the diluent container, for switching between a communication of the second syringe with the diluent container and a communication of the second syringe with the first syringe; a bath; a sample buffer tube communicated with the first syringe at a port thereof; a dispensing tube for dispensing the measurement sample and/or the diluent into the bath; a second switching unit connected to an output port of the aspirating tube, the other port of the sample buffer tube and an input port of the dispensing tube, for switching between a communication of the other port of

Abstract: A gas turbine engine is provided with turbine sealing structures including knife edge seals which extend at an angle relative to an axial center line of the engine. Each knife edge seal is associated with a concave pocket defined between a radially inner surface and a spaced radially outer surface. The concave pockets and their associated knife edge seals create a pair of vortices which prevent leakage into radially inner portions of the turbine section.

Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R1 and R2 are as defined herein, and their methods of preparation and use as ADP inhibitors.

Abstract: A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tethered and untethered target molecules; (3) detecting the radiation impinged on the tethered molecule to form a reference signal and the radiation impinged on the sample to form a sample signal; and (4) comparing the reference signal with the sample signal to generate a specimen signal indicative of an association between the selected tethered and target molecules. The method will detect whether a selected tethered molecule and the desired target exhibit any affinity or, in cases where the affinity is known, will detect the presence of the target molecule in a sample. Also provided is an apparatus for detecting specific associations between a tethered molecule and an untethered target molecule.

Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: Improved bimetallic nanocatalysts are manufactured using a control agent to produce nanoparticles having a controlled crystal face exposure. The bimetallic nanocatalyst particles are manufactured in a two-step process. In a first step, nanocatalyst particles are manufactured using the control agent and the primary metal atoms. The primary metal atoms and the control agent are reacted to form complexed metal atoms. The complexed metal atoms are then allowed or caused to form nanoparticles. The nanoparticles formed in the first step using the control agent have a desired crystal face exposure. In a second step, the secondary metal atoms are deposited on the surface of the primary metal nanoparticles. The secondary catalyst atoms maintain the same crystal face exposure as the primary metal nanoparticles.

Abstract: A method for generating amplified terahertz radiation includes inducing a first volume of a gas to produce a seed plasma and emit pulsed seed terahertz radiation by focusing an optical seed beam in the first volume. The seed terahertz radiation is then amplified by focusing an optical gain beam to produce a gain plasma in a second volume overlapping with the pulsed seed terahertz radiation remote from the seed plasma. The method may be implemented in a system for detecting and analyzing a remotely-located object such as an explosive material, a biological agent, and a chemical agent.

Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: An implantable medical device is adapted for implantation into body tissue. The implantable medical device comprises a housing and a header coupled to the housing. A cavity is located in the header. An ultrasonic transducer adapted to transmit acoustic waves at a communication frequency is located in the cavity, and a coupling surface is interposed between the ultrasonic transducer and the body tissue and is acoustically coupled with the body tissue.

Abstract: A mounting apparatus is provided for mounting a data storage device to a drive bracket. The data storage device is locked to the drive bracket via a locking module. The locking module includes a housing member attached to the drive bracket, and a pushing member, a locking member, and a releasing member that are attached to the housing member. The pushing member is driven by a pushing action of the data storage device for releasing the locking member in a first direction for locking the data storage device. The locking member is driven by the releasing member for unlocking the data storage device in an opposite direction with respect to the first direction.

Abstract: A biosensor for determining the concentration of an analyte in a biological sample. The biosensor comprises a support, a reference electrode or a counter electrode or both a reference and a counter electrode disposed on the support, a working electrode disposed on the support, the working electrode spaced apart from the other electrode or electrodes on the support, a covering layer defining a sample chamber over the electrodes, an aperture in the covering layer for receiving a sample, and at least one layer of mesh in the sample chamber between the covering layer and the electrodes. The at least one layer of mesh has coated thereon a silicone surfactant. Certain silicone surfactants are as effective as fluorinated surfactants with respect to performance of biosensors. These surfactants, when coated onto the mesh layer of the biosensor, are effective in facilitating the transport of aqueous test samples, such as blood, in the sample chamber.