Abstract: A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.

Abstract: A mounting apparatus for mounting two or more types of data storage devices that each defines a locking hole in a sidewall thereof includes a bracket for holding the data storage devices, a fixing member, and a locking member. The bracket includes a first side wall. The first side wall defines a locating hole therein. The locating hole has at least two locating positions. The fixing member is pivotably mounted to the first side wall of the bracket. The locking member is selectively mounted to at least two positions of the fixing member. The locking member includes a locking portion extending therefrom, for selectively being inserted through the at least two locating positions of the locating hole of the bracket to engage in the locking hole of a corresponding type of data storage device.

Abstract: A group-browsing system for a plurality of clients each including a shared web browser when browsing non-secure parts of a web site. A server is linked to the shared web browser of each client and is configured to monitor the transmission of the web site URL request from the shared web browser of one client of the group and to direct the request to the shared web browser of other clients in the group. A gatekeeper module is configured to first mask the identity of each client's computer on the shared browser. This prevents the web site from retrieving any client's actual identifier. Second, the gatekeeper is also configured to create a same temporary identifier for each client when any client logs on to the web site so that the same web page is displayed for all the clients in the group. When browsing secure parts of a web site, a non-shared web browser is executed instead of using the shared web browser to avoid sharing sensitive or personal information.

Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: The present invention discloses a liquid volumetric device comprising a metering tube, a start sensor, an end sensor, a bath for storage of a sample to be metered, a vacuum chamber and a pump for pumping out air inside the vacuum chamber to form a negative pressure inside the vacuum chamber. The start sensor and the end sensor are provided respectively at the bottom and the top of the metering tube, the top of the metering tube is in communication respectively with the vacuum chamber and the outside atmosphere via pipelines, the bottom of the metering tube is in communication respectively with the bath and the vacuum chamber via pipelines, and control parts are provided in each of the pipelines for controlling connection/disconnection thereof.

Abstract: Methods for manufacturing carbon nanostructures include: 1) forming a plurality of catalytic templating particles using a plurality of dispersing agent molecules; 2) forming an intermediate carbon nanostructure by polymerizing a carbon precursor in the presence of the plurality of templating nanoparticles; 3) carbonizing the intermediate carbon nanostructure to form a composite nanostructure; and 4) removing the templating nanoparticles from the composite nanostructure to yield the carbon nanostructures. The carbon nanostructures are well-suited for use as a catalyst support. The carbon nanostructures exhibit high surface area, high porosity, and high graphitization. Carbon nanostructures according to the invention can be used as a substitute for more expensive and likely more fragile carbon nanotubes.

Abstract: A method for generating terahertz radiation includes inducing a background plasma in a volume of a gas by focusing a first optical beam in the volume, and generating pulsed terahertz radiation with enhanced generation efficiency by focusing a second time-delayed optical beam in the background plasma. The method may be implemented in a system for detecting and analyzing a remotely-located object.

Abstract: A system and method for waking up an implantable medical device (“IMD”) from a sleep state in which power consumption by the IMD is essentially zero. The IMD may be adapted to perform one or more designated measurement and/or therapeutic functions. In one embodiment, the IMD includes a wake-up sensor that is adapted to sense the presence or absence of a wake-up field generated by another IMD or an external device. The wake-up field may, in some embodiments, be an electromagnetic field, a magnetic field, or a physiologically sub-threshold excitation current (i.e., E-field). Upon sensing by the wake-up sensor of the wake-up field, other components of the IMD, which may include a controller, a sensing and/or therapy module, and/or a communications module, are awakened to perform one or more designated functions.

Abstract: Supported catalysts include an inorganic solid support such as silica that is functionalized to have inorganic acid functional groups attached thereto. The functionalization of the support material is optimized by (i) limiting the amount of water present during the functionalization reaction, (ii) using a concentrated mineral acid or derivative thereof, and/or (iii) increasing the reaction temperature and/or reaction pressure. The acid-functionalized support material serves as a support for a metal nanoparticle catalyst. The nanocatalyst particles are preferably bonded to the support material through an organic molecule, oligomer, or polymer having functional groups that can bind to both the nanocatalyst particles and to the support material. The supported catalysts can advantageously be used for the direct synthesis of hydrogen peroxide from hydrogen and oxygen feed streams.

Abstract: Metal-containing colloids are manufactured by reacting a plurality of metal ions and a plurality of organic agent molecules to form metal complexes in a mixture having a pH greater than about 4.25. The metal complexes are reduced for at least 0.5 hour to form stable colloidal nanoparticles. The extended reduction time improves the stability of the colloidal particles as compared to shorter reduction times. The stability of the colloidal particles allows for colloids with higher concentrations of metal to be formed. The concentration of metal in the colloid is preferably at least about 150 ppm by weight.

Abstract: A method for manufacturing stable concentrated colloids containing metal nanoparticles in which the colloid is stabilized by adding a base. This allows the metal particles to be formed in higher concentration without forming larger agglomerates and/or precipitating. The method of manufacturing the stable colloidal metal nanoparticles of the present invention generally includes (i) providing a solution comprising a plurality of metal atoms, (ii) providing a solution comprising a plurality of organic agent molecules, each organic agent molecule comprising at least one functional group capable of bonding to the metal atoms, (iii) reacting the metal atoms in solution with the organic agent molecules in solution to form a mixture comprising a plurality of complexed metal atoms, (iv) reducing the complexed metal atoms in the mixture using a reducing agent to form a plurality of nanoparticles, and (v) adding an amount of a base to the mixture, thereby improving the stability of the nanoparticles in the mixture.

Abstract: This invention is directed to pyridine-containing macroheterocyclic compounds useful as kinase inhibitors, methods for producing such compounds and methods for treating or preventing a kinase mediated disorder.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: A broad bandwidth detector to measure intensity information of terahertz (THz) frequency pulses. The detector includes: coupling optics coupled to a coherent optical source; a GaSe substrate aligned such that the probe beam path intersects a first surface at a phase-matching angle; a polarization detector aligned in the probe beam path; and calculation means coupled to the polarization detector. The coupling optics direct the probe optical beam along a beam path that is substantially collinear with the pulse beam path of the THz frequency pulses. The polarization of the probe optical beam is varied based on interactions between the probe optical beam and the THz frequency pulses within the GaSe substrate. The polarization detector detects the varied polarization of the probe optical beam. The calculation means determine the intensity information of the THz frequency pulses based on the detected probe polarization of the probe optical beam.

Abstract: An embodiment of a system for gathering physiologic data related to a human body includes a sensor device implanted in the human body, an inductive coil communicably coupled to the implanted sensor device; and a manager device in communication with the implanted sensor device via the inductive coil. The coil may be wrapped around the sensor device or attached to the sensor device fixation. An embodiment of a method for gathering physiologic data related to a physiologic parameter in a human body includes communicably coupling an inductive coil to communication circuitry of an implantable medical device (IMD), deploying the inductive coil and the IMD into a vessel of the human body, and inducing current in the inductive coil via the communication circuitry, the current representative of data associated with the IMD.

Abstract: An optical delay line for use with an optical source including input/output optics optically coupled to the optical source and a curved mirror with a reflective surface that is centered about an evolute curve of the delay line to retro-reflect light traveling along a delay line beam path tangent to the edge of the evolute curve. The input/output optics direct light from the optical source along the delay line beam path and direct delayed light from the delay line beam path out of the optical delay line along an output beam path. The input/output optics and/or the curved mirror rotate about the evolute curve at a selected angular speed. The reflective surface has a curvature based on a parametric curve that is calculated from the evolute curve such that the delay of the delay line varies according to a predetermined function as the input/output optics and/or the curved mirror rotate.

Abstract: A battery management circuit provides an implantable medical device with power management that allows safe and efficient use of a rechargeable battery. Various ways of monitoring the energy level of the rechargeable battery and controlling the battery recharging process for user convenience and safety are provided.

Abstract: A crystallizable glass of Li2O—Al2O3—SiO2 system is provided, which can be crystallized by a crystallization process at a lower temperature to produce crystallized glass of Li2O-Al2O3—SiO2 system with excellent thermal characteristics. The crystallizable glass of Li2O—Al2O3—SiO2 system which consists essentially of, by weight percentages, SiO2—58.0˜66.0 wt %; Al2O3—18.0˜26.0 wt %; Li2O—3.5˜5.5 wt %; TiO2—0.5-4.0 wt %; ZrO2—0.5˜3.0 wt % P2O5—0.5˜3.0 wt %; F—0.1˜1.0 wt %; B2O3—0˜2.5 wt %; Na2O—0˜2.0 wt %; K2O—0˜2.0 wt %; MgO—0˜1.0 wt %; ZnO—0.5˜3.0 wt %; BaO—0˜2.5 wt %; SrO—0.3˜3.0 wt % As2O3—0.4˜1.5 wt %; and Sb2O3—0˜1.5 wt %.

Abstract: A method of analyzing a remotely-located object includes the steps of inducing a volume of an ionized ambient gas to emit pulsed terahertz radiation directed toward a targeted object by focusing an optical pump beam in the volume and ionizing another volume of the ambient gas to produce a sensor plasma by focusing an optical probe beam in the other volume of ambient gas. The interaction, in the sensor plasma, of the focused optical probe beam and an incident terahertz wave, which is produced by the targeted object reflecting, scattering, or transmitting the pulsed terahertz radiation, produces a resultant radiation. Detecting an optical component of the resultant radiation emitted by the sensor plasma facilitates detection of a signature of the targeted object imposed onto the incident terahertz radiation.