Abstract: A cardiovascular pressure data analyzing system having one or more implanted pressure sensors, an implanted communication device in wireless communication with the sensor and an external data processing unit adapted to use real-time barometric data to calibrate uncalibrated pressure data received from the communication device. The external data processing unit can be portable, is in communication with a remote database to transfer the calibrated pressure data to the remote database, and is capable of providing reprogramming information to the communication device. A method of analyzing pressure data including gathering pressure data from an implanted pressure sensor in a human body, retrieving the pressure data through a communication device implanted in the human body, transmitting pressure data from the communication device to an external data processing unit, and calibrating the pressure data at the external processing unit to compensate for inherent characteristics of the sensor.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: A device for use with a source of radiation to provide a THz emission image representing a sample. The device comprises a substrate, a metallic probe having a tip adjacent to the substrate surface and a source of AC bias coupled between the probe tip and substrate. Radiation generated by the source of radiation is incident on the substrate surface in the vicinity of the probe tip and generates THz emission based at least on the AC bias coupled between the probe tip and substrate. A method for providing a THz emission image representing a sample is also provided.

Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disease, condition or disorder.

Abstract: Systems and methods for treating raw materials for formation into a wood product are provided. The raw materials may be, for example, strands, flakes, particles, wafers, or the like. In an embodiment, a first dispensing device dispenses a first liquid component onto raw materials within a chamber. A second dispensing device dispenses a second liquid component onto the raw materials. When the raw materials are mixed together, the first and second liquid components interact to form a bonding agent.

Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: An optical delay line for use with an optical source including input/output optics optically coupled to the optical source and a curved mirror with a reflective surface that is centered about an evolute curve of the delay line to retro-reflect light traveling along a delay line beam path tangent to the edge of the evolute curve. The input/output optics direct light from the optical source along the delay line beam path and direct delayed light from the delay line beam path out of the optical delay line along an output beam path. The input/output optics and/or the curved mirror rotate about the evolute curve at a selected angular speed. The reflective surface has a curvature based on a parametric curve that is calculated from the evolute curve such that the delay of the delay line varies according to a predetermined function as the input/output optics and/or the curved mirror rotate.

Abstract: A group-browsing system for a plurality of clients each including a shared web browser. A server is linked to the shared web browser of each client and is configured to monitor the transmission of the web site URL request from the shared web browser of one client of the group and to direct the request to the shared web browser of other clients in the group. A gatekeeper module is configured to first mask the identity of each client's computer on the shared browser. This prevents the web site from retrieving any client's actual identifier. Second, the gatekeeper is also configured to create a same temporary identifier for each client when any client logs on to the web site so that the same web page is displayed for all the clients in the group.

Abstract: The present invention is directed to a demodulating circuit adapted for reproducing, from an input signal which has been caused to undergo transmission through a desired transmission system, data sequential caused to undergo transmission through the input signal, which is adapted to perform phase comparison, by Exclusive-OR (EX-OR) circuits (254Q), (254I), between a first oscillating output signal generated by an oscillator (252) and a variable frequency divider (253) and a second oscillating output signal different from the first oscillating output signal by 90 degrees [?/2] in phase to judge control direction by a control direction judgment circuit (257) on the basis of polarities of the phase comparison results to integrate the control direction judgment results by one period of the input signal by an integrating circuit (258) to perform correction processing having a predetermined controlled variable in the case where phase difference is [±?/2] on the basis of the phase comparison result by a correction c

Abstract: Reishi extract compositions and methods for preparation and use thereof are disclosed and described. In various aspects, methods for inhibiting IL-5 secretion, and preventing and/or treating allergies are described, which include administering therapeutically effective amounts of compositions containing reishi extracts to subjects.

Abstract: A method of obtaining a series of images of a three-dimensional object. The method includes the steps of transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a two-dimensional array of parallel rays. The optical detection is an array of detectors such as a CCD sensor.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

Abstract: A method of obtaining a series of images of a three-dimensional object by transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a scanning spot. The object is placed within the Rayleigh range of the focused THz beam and a focusing system is used to transfer the imaging plane from adjacent the object to a desired distance away from the object. A related system is also disclosed.

Abstract: A broad bandwidth detector to measure intensity information of terahertz (THz) frequency pulses. The detector includes: coupling optics coupled to a coherent optical source; a GaSe substrate aligned such that the probe beam path intersects a first surface at a phase-matching angle; a polarization detector aligned in the probe beam path; and calculation means coupled to the polarization detector. The coupling optics direct the probe optical beam along a beam path that is substantially collinear with the pulse beam path of the THz frequency pulses. The polarization of the probe optical beam is varied based on interactions between the probe optical beam and the THz frequency pulses within the GaSe substrate. The polarization detector detects the varied polarization of the probe optical beam. The calculation means determine the intensity information of the THz frequency pulses based on the detected probe polarization of the probe optical beam.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

Abstract: An apparatus and a method for the generation of high-energy terahertz radiation. The apparatus and method function by impinging optical radiation on the surface of a semiconductor substrate, creating a photo-generated dipole emitting terahertz radiation. Because it is desirable to orient the dipole perpendicular to the radiation direction to maximize the power of the terahertz radiation, the surface of the semiconductor is modified to achieve this desirable result. More specifically, three embodiments of the surface modification are disclosed: (1) a grating is created in the top surface of a GaAs semiconductor substrate, (2) an InAs film is formed on a Teflon base to create a grating structure on the semiconductor substrate, and (3) a grating is disposed in the surface of the semiconductor substrate such that the optical radiation engages the substrate at Brewster's angle.

Abstract: Systems and methods for reconstructing a plurality of images of an object. An exemplary system includes a radiation source adapted to emit radiation at a plurality of frequencies; a lens with frequency-dependent focal length, such as a Fresnel lens, adapted to receive radiation modified by the object and to project onto a fixed image plane a frequency-dependent image of a slice of the object perpendicular to the radiation path; a sensor for capturing the frequency-dependent image of the object; and apparatus for facilitating creation and capture of a plurality of frequency-dependent images of the object at the plurality of frequencies. A system for reconstructing a tomographic image of the object further includes apparatus for assembling the plurality of frequency-dependent images to reconstruct the tomographic image. Methods and systems are described for use in the visible, audible, and THz frequency ranges and with broadband or narrowband radiation sources.

Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.