Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: Sterically stabilized second-order nonlinear optical chromophores and devices incorporating the same are embodied in a variety of chromophore materials. An exemplary preferred chromophore includes an electron donor group, an electron acceptor group and a ring-locked bridge structure therebetween, with the bridge structure being directly connected to the electron donor via a single bond. Another exemplary preferred chromophore includes an electron donor group, an electron acceptor group and a ring-locked bridge structure between the electron donor group and the electron acceptor group, with two free double bonds, one located between the donor and the bridge and the other located between the (fused) ring bridge and the acceptor. Another exemplary preferred chromophore includes an electron donor group, an electron acceptor group, and a bridge structure therebetween, with the chromophores having no carbon-carbon double bond between the donor and the (fused) ring bridge.

Abstract: A DSR system and method is disclosed. A DSR system comprising: a client to send connection requests, receive displayable content, and transmit speech feature data to a server; a gateway coupled between the client and the server to support data communication between the client and the server; and a server to receive the speech feature data, perform speech recognition on the speech feature data, and transmit displayable content to the client.

Abstract: The present invention provides a damping composite material, exhibiting more stable and functional damping effects than the conventional one based on the viscous or functional mechanism to convert mechanical vibrational energy into thermal energy, and also provide a method for producing the same.

Abstract: Characterization of free-space electromagnetic energy pulses (15) using a chirped optical probe beam is provided. An electro-optic or magneto-optic crystal (14) is positioned such that the free-space radiation and chirped optical probe signal co-propagate, preferably in a co-linear common direction, through the crystal where a temporal waveform of the free-space radiation is linearly encoded onto a wavelength spectrum of the chirped optical probe signal. The temporal waveform of the free-space radiation is then reconstructed using, for example, a dynamic subtraction of the spectral distribution of the chirped optical probe signal without modulation from the spectral distribution of the chirped optical probe signal with modulation by the free-space radiation.

Abstract: The present invention provides a damping composite material, exhibiting more stable and functional damping effects than the conventional one based on the viscous or frictional mechanism to convert mechanical vibrational energy into thermal energy, and also provide a method for producing the same. The damping material of the present invention comprises at least a material showing piezoelectric, dielectric and electroconductive effects, and an organic polymer matrix material, wherein the material showing piezoelectric, dielectric and electroconductive effects is a compound containing a phenolic group, and the method of the present invention for producing the damping material comprises two steps, one uniformly mixing the material showing piezoelectric, dielectric and electroconductive effects with the organic polymer matrix material at normal temperature or higher, and the other forming the mixture by pressing or drawing at high temperature.

Abstract: Second-order nonlinear optical (NLO) polyene-based chromophores sterically stabilized with a dioxine ring and NLO chromophores containing bithiophene derivatives, and devices incorporating the same, are disclosed. An exemplary preferred chromophore includes an aminophenyl electron donor group and a dioxine-containing bridge structure. Another exemplary preferred chromophore includes a ring-locked bridge structure with a dioxine unit and a bithiophene unit. Another exemplary preferred chromophore includes a bridge structure with a bithiophene unit and an isophorone-derived cyclohexene unit.

Abstract: A non-contact, free-space method for determining the index of refraction of a thin film at a desired angular frequency. The method includes generating an input desired-frequency pulse and an optically detectable probe pulse. The thin film is moved in and out of the path of the input pulse, creating an output pulse that alternates between a transmitted signal, created when the film intercepts the input pulse path, and a reference signal, created when the sample is outside the input pulse path. The output pulse modulates the probe pulse, which is then detected with a photo detector, and the difference between the transmitted signal and the reference signal is calculated. The above steps are repeated over a plurality of delay times between the input pulse and the probe pulse until a complete field waveform of the differential signal is characterized. The index of refraction is calculated as a function of a ratio between the differential signal for the thin film and the reference signal.

Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): 1

Abstract: Characterization of free-space electromagnetic energy pulses (15) using a chirped optical probe beam is provided. An electro-optic or magneto-optic crystal (14) is positioned such that the free-space radiation and chirped optical probe signal co-propagate, preferably in a co-linear common direction, through the crystal where a temporal waveform of the free-space radiation is linearly encoded onto a wavelength spectrum of the chirped optical probe signal. The temporal waveform of the free-space radiation is then reconstructed using, for example, a dynamic subtraction of the spectral distribution of the chirped optical probe signal without modulation from the spectral distribution of the chirped optical probe signal with modulation by the free-space radiation.

Abstract: An ultrafast all-optical nonlinear switch. The switch has as components a substrate and a material disposed on the substrate. In one embodiment, the material includes a plurality of single-walled carbon nanotubes and a polymer forming a composite. Preferably, the polymer is polyimide. In another embodiment, the material includes a plurality of single-walled carbon nanotubes incorporated into a silica. The nanotube loading in the material is less than about 0.1 wt %. The material is a substantially transparent, third-order nonlinear optical material. The switch has a switching speed of less than 1 picosecond for light with a wavelength of about 1.55 micrometers. Also disclosed is a process for preparing the ultrafast all-optical nonlinear switch.

Abstract: The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.

Abstract: A method of improving spatial resolution of a pump-probe terahertz (THz) imaging system for producing an image of an object. The method provides a chopped optical gating beam focused on a semiconductive layer that is either part of the object or a discrete layer placed over the object. The gating beam is focused on a gating pulse focal spot having a diameter effective to cause measurable modulation in transmission of a THz beam through the semiconductive layer when the gating pulse is on as compared to when the gating pulse is off, creating alternating modulated THz beams for detection and processing. Systems for performing the method in transmission and reflection modes are also described.

Abstract: A non-contact, free-space method for determining the index of refraction of a thin film at a desired angular frequency. The method includes generating an input desired-frequency pulse and an optically detectable probe pulse. The thin film is moved in and out of the path of the input pulse, creating an output pulse that alternates between a transmitted signal, created when the film intercepts the input pulse path, and a reference signal, created when the sample is outside the input pulse path. The output pulse modulates the probe pulse, which is then detected with a photo detector, and the difference between the transmitted signal and the reference signal is calculated. The above steps are repeated over a plurality of delay times between the input pulse and the probe pulse until a complete field waveform of the differential signal is characterized. The index of refraction is calculated as a function of a ratio between the differential signal for the thin film and the reference signal.

Abstract: Characterization of free-space electromagnetic energy pulses (15) using a chirped optical probe beam is provided. An electro-optic or magneto-optic crystal (14) is positioned such that the free-space radiation and chirped optical probe signal co-propagate, preferably in a co-linear common direction, through the crystal where a temporal waveform of the free-space radiation is linearly encoded onto a wavelength spectrum of the chirped optical probe signal. The temporal waveform of the free-space radiation is then reconstructed using, for example, a dynamic subtraction of the spectral distribution of the chirped optical probe signal without modulation from the spectral distribution of the chirped optical probe signal with modulation by the free-space radiation.

Abstract: An organohybrid-based damping material for controlling unwanted vibration and noise, an organic damping improver exhibiting piezoelectric, dielectric and electroconductive effects, and their producing methods, are provided. The damping material comprises a polymer matrix having a polar side chain and a damping improver composed of a compound containing basic nitrogen and a phenol-based compound. The damping material shows an excellent damping properties, alleviates the functional deterioration, and is applicable to different application temperature regions and wide areas.

Abstract: The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: Sterically stabilized second-order nonlinear optical chromophores and devices incorporating the same are embodied in a variety of chromophore materials. An exemplary preferred chromophore includes an electron donor group, an electron acceptor group and a bridge structure therebetween, with the electron acceptor group being double bonded to the bridge structure. In a preferred embodiment, the bridge structure also includes at least one bulky side group. Another exemplary preferred chromophore includes an electron donor group, an electron acceptor group and a ring-locked bridge structure between the electron donor group and the electron acceptor group. The bridge structure comprises, for example, two protected alicyclic rings or ring-locked trienone. Another exemplary preferred chromophore includes an electron donor group, a ring-locked tricyano electron acceptor group, and a bridge structure therebetween. In a preferred embodiment, the electron acceptor group comprises an isophorone structure.

Abstract: A group-browsing system for a plurality of clients each including a shared web browser. A server is linked to the shared web browser of each client and is configured to monitor the transmission of the web site URL request from the shared web browser of one client of the group and to direct the request to the shared web browser of other clients in the group. A gatekeeper module is configured to first mask the identity of each client's computer on the shared browser. This prevents the web site from retrieving any client's actual identifier. Second, the gatekeeper is also configured to create a same temporary identifier for each client when any client logs on to the web site so that the same web page is displayed for all the clients in the group.