Abstract: A projection apparatus is provided, including a lens module, a movement element, a sensing element, and a lens control element. When the lens module moves to the origin position, the lens control element controls an image beam to focus on a first position on a reference plane in one of the tele mode and the wide mode, the lens control element controls the image beam to focus on a second position on the reference plane in the other mode, and the lens control element determines whether there is an offset between the first position and the second position. When the offset exists, the lens control element adjusts a movement parameter value of the movement element based on the offset value between the first position and the second position, so that the image beam is focused on the same position on the reference plane in the tele mode and wide mode.

Abstract: A method for manufacturing a golf ball having a multi-layered pattern is provided. Firstly, a semi-finished product of the golf ball is provided and includes a ball-shaped body and a base layer covering an outer surface of the ball-shaped body. Then, the semi-finished product of the golf ball is rotated at a predetermined rotation speed, and a color paint is applied to the semi-finished product of the golf ball by spraying from each of an upper position, a middle position, and a lower position. The multi-layered pattern includes an upper-layer pattern area, a mid-layer pattern area, and a lower-layer pattern area that are different in color from each other.

Abstract: A lens module and a fastening assembly are provided. The lens module includes a carrier, a lens having at least one fastening part, at least one fastening assembly including first and second fastening members, and at least one elastic member disposed between the carrier and the fastening part to push the fastening part toward the second fastening member. The first fastening member has a first external thread and a second external thread. The first external thread has a different pitch from the second external thread. The second fastening member has a first internal thread. The first fastening member penetrates the fastening part and is fastened to the carrier by the first external thread. The first and second fastening members are mutually fastened by the second external thread and the first internal thread, so that the fastening part is limited between the second fastening member and the carrier.

Abstract: An apparatus and method of indicating the ball center of gravity position. The method of indicating the ball center of gravity position includes the following step of: moving the ball to a rotating member of a rotating device; driving the rotating member to rotate the ball along a axis of rotation of the rotating device, and adjust the center of gravity of the ball corresponding to the position of the rotating device; moving the ball onto a first carrier of a first transport device; and marking an identification mark on a predetermined area of the ball.

Abstract: An apparatus for manufacturing golf balls each having an exterior pattern includes a conveying device and a spraying device. The spraying device is disposed at one side of a first processing area. The conveying device is configured to convey a ball-shaped body into the first processing area along a predetermined path, and to rotate the ball-shaped body at a predetermined speed. The spraying device includes a first sprayer and a second sprayer. The first sprayer and the second sprayer are configured to apply a color paint to the ball-shaped body from each of an upper position and a lower position.

Abstract: A method for manufacturing a golf ball having a non-uniform dot pattern is provided. Firstly, a semi-finished product of a golf ball is provided, which includes a ball body and a base layer covering an outer surface of the ball body. After that, the semi-finished product of the golf ball is rotated at a predetermined rotation speed, and a color paint is applied to the semi-finished product of the golf ball in a spraying manner from each of an upper position and a lower position.

Abstract: The light source device includes a substrate, a light emitting unit mounted on the substrate, a frame disposed on the substrate, a metal shield fixed to an inner side of the frame and electrically coupled to the substrate, a light permeable member disposed on the frame, a cover plate disposed on the light permeable member and fixed to the frame, a detection unit electrically coupled to the substrate, and an uplift block that provides for the substrate to be disposed thereon.

Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab?(L?D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

Abstract: A light source device includes a substrate, an upper electrode layer and a lower electrode layer both respectively disposed on two opposite surfaces of the substrate, a light emitting unit mounted on the upper electrode layer, a surrounding frame disposed on the substrate and surrounding the light emitting unit, a conductive unit disposed on the surrounding frame, a light permeable member disposed on the surrounding frame and covering the light emitting unit, and a detecting circuit formed on an outer surface of the light permeable member. The lower electrode layer includes two coplanar sub-layers. The light emitting unit is electrically coupled to one of the two sub-layers through the upper electrode layer. The detecting circuit includes two contacts connected to the conductive unit, and is electrically coupled to the second lower electrode sub-layer by the conductive unit electrically coupled to the other one of the two sub-layers.

Abstract: An apparatus and method of indicating the ball center of gravity position. The method of indicating the ball center of gravity position includes the following step of: moving the ball to a rotating member of a rotating device; driving the rotating member to rotate the ball along a axis of rotation of the rotating device, and adjust the center of gravity of the ball corresponding to the position of the rotating device; moving the ball onto a first carrier of a first transport device; and marking an identification mark on a predetermined area of the ball.

Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX?SGNRRYZLV (SEQ ID NO:7, wherein X? is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).

Abstract: An antibody, or an antigen-binding fragment there, binding human ENO1 (GenBank: AAH506421.1) is provided. Methods for treating an ENO1 protein-related disease or disorder, inhibiting cancer invasion and diagnosis of cancer are also provided.

Abstract: The light source device includes a substrate, a light emitting unit mounted on the substrate, a frame disposed on the substrate, a metal shield fixed to an inner side of the frame and electrically coupled to the substrate, a light permeable member disposed on the frame, a cover plate disposed on the light permeable member and fixed to the frame, a detection unit electrically coupled to the substrate, and an uplift block that provides for the substrate to be disposed thereon.

Abstract: Detecting system and detecting method are for detecting deformation degree of capacitive touch device's touch surface. Detecting system has a deformation detecting component and a computer. The deformation detecting component has two conductive supporters, conductive reference member mounted on the conductive supporters and having straight edge, and deformation degree measuring member. The conductive base has a measuring surface, a bottom surface, and an acute angle formed between the bottom surface and the measuring surface. The electrical conductor layers are sequentially arranged on the measuring surface and have different electrical impedance values. When the deformation degree measuring member is inserted between the straight edge, the conductive supporters and the touch surface, the conductive base, the conductor layers and the straight edge are electrically conducted, the capacitive touch device generates deformation degree signal.

Abstract: A light source device includes a substrate, an upper electrode layer and a lower electrode layer both respectively disposed on two opposite surfaces of the substrate, a light emitting unit mounted on the upper electrode layer, a surrounding frame disposed on the substrate and surrounding the light emitting unit, a conductive unit disposed on the surrounding frame, a light permeable member disposed on the surrounding frame and covering the light emitting unit, and a detecting circuit formed on an outer surface of the light permeable member. The lower electrode layer includes two coplanar sub-layers. The light emitting unit is electrically coupled to one of the two sub-layers through the upper electrode layer. The detecting circuit includes two contacts connected to the conductive unit, and is electrically coupled to the second lower electrode sub-layer by the conductive unit electrically coupled to the other one of the two sub-layers.

Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX?SGNRRYZLV (SEQ ID NO:7, wherein X? is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).

Abstract: A recombinant protein drug includes a parent protein drug coupled with a modified kininogen-1 peptide. The modified kininogen-1 peptide has the sequence of SEQ ID NO:2 or a homolog having a sequence identity of 80% or higher. The parent protein drug is a bispecific antibody having a first targeting domain linked by a bridging domain with a second targeting domain. The modified kininogen-1 peptide is fused between the first targeting domain and the bridging domain, or between the bridging domain and the second targeting domain. A method for increasing the serum half-life of a protein drug includes constructing a fusion protein comprising the protein drug coupled with a modified kininogen-1 peptide.

Abstract: An antibody, or an antigen-binding fragment there, binding human ENO1 (GenBank: AAH506421.1) is provided. Methods for treating an ENO1 protein-related disease or disorder, inhibiting cancer invasion and diagnosis of cancer are also provided.

Abstract: The present invention provides a modified antigen-binding Fab fragment. An antigen-binding molecule comprising the antigen-binding Fab fragment and a composition comprising the molecule are also provided.

Abstract: An antibody prodrug capable of being selectively activated in a central nervous system (CNS) by protease KLK6 includes an antibody for treating a disease or disorder in the CNS; a KLK6 cleavable peptide fused to an N-terminus of a heavy chain and/or a light chain of the antibody; and a blocker fused to an N-terminus of the KLK6 cleavable peptide. The disease or disorder is a cancer, inflammatory disease, autoimmune disease, infectious disease, or neuron degeneration disease.