Abstract: The present disclosure relates to trial scleral lenses, and the resulting scleral lenses, designed for the asymmetric shape of the sclera and/or its chiral properties. In some embodiments, the scleral lenses are also designed for the specific asymmetry associated with different scleral diameters. In addition, as discussed herein, the scleral shape can vary with different conditions of the eye. By designing a set of trial scleral lenses that takes into account these different asymmetric properties of the sclera, a clinician can be more efficient, fitting more eyes with fewer subsequent modifications. The resulting lenses will also achieve a better fit.

Abstract: A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp2-sp3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation.

Abstract: Existing currency validation (CVAL) devices, systems, and methods are too slow, costly, intrusive, and/or bulky to be routinely used in common transaction locations (e.g., at checkout, at an automatic teller machine, etc.). Presented herein are devices, systems, and methods to facilitate optical validation of documents, merchandise, or currency at common transaction locations and to do so in an obtrusive and convenient way. More specifically, the present invention embraces a validation device that may be used alone or integrated within a larger system (e.g., point of sale system, kiosk, etc.). The present invention also embraces methods for currency validation using the validation device, as well as methods for improving the quality and consistency of data captured by the validation device for validation.

Abstract: A method of modulating a cooling supply in a gas turbine engine includes providing the engine comprising a compressor section and a turbine section and including a cooling flow circuit, the cooling flow circuit supplying a cooling air flow from a compressor cavity in the compressor section to a blade ring cavity in the turbine section, wherein the cooling flow circuit includes a main line with a full capacity valve, measuring a first pressure in the blade ring cavity, measuring a second pressure in the compressor cavity, adjusting, by a control system, the opening of the full capacity valve to control the cooling air flow through the main line in order to maintain a target pressure ratio, wherein the pressure ratio defined as a ratio of the first pressure to the second pressure. The method is performed in an ambient temperature operating range of the engine.

Abstract: A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp2-sp3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation.

Abstract: The present invention relates to Fc variant protein and preparation thereof. Said Fc variant has altered binding affinity towards FcRn. Fc variant prepared according to the current invention can be used for making FcRn antagonist composition or can be used for making an Fc variant containing drug or molecule with altered effector function.

Abstract: Some embodiments described in this disclosure are directed to interactions and/or user interfaces for enhancing remote management of one or more electronic devices.

Abstract: Provided herein are engineered TSC2 polypeptides, and nucleic acid sequences encoding them, in which the ability of a serine residue to be phosphorylated is altered. In some aspects, the TSC2 serine residue cannot be phosphorylated (e.g., by substituting the serine residue with an alanine residue). In some aspects, the TSC2 serine acts as if it is constitutively phosphorylated (e.g., by substituting the serine residue with a glutamic acid residue). Also provided herein are engineered immune cells comprising altered TSC2 polypeptides or nucleic acid sequences encoding them, and methods of making and using such engineered immune cells.

Abstract: A method of modulating a cooling supply in a gas turbine engine includes providing the engine comprising a compressor section and a turbine section and including a cooling flow circuit, the cooling flow circuit supplying a cooling air flow from a compressor cavity in the compressor section to a blade ring cavity in the turbine section, wherein the cooling flow circuit includes a main line with a full capacity valve, measuring a first pressure in the blade ring cavity, measuring a second pressure in the compressor cavity, adjusting, by a control system, the opening of the full capacity valve to control the cooling air flow through the main line in order to maintain a target pressure ratio, wherein the pressure ratio defined as a ratio of the first pressure to the second pressure. The method is performed in an ambient temperature operating range of the engine.

Abstract: Methods, systems, and devices for wireless communication are described. A base station may determine a measurement scheme or uplink mode and then transmit an indication of the scheme or uplink mode to an associated user equipment (UE). The base station may identify a set of hidden nodes for the UE and configure the UE for autonomous or grant-based uplink transmissions accordingly. A UE may initiate a channel clearance scheme by transmitting a first channel clearance signal (e.g., a request-to-send message), which may include a UE identifier before transmitting an uplink message in the unlicensed radio frequency spectrum band. In response, the base station may transmit a second channel clearance signal (e.g., a clear-to-send message). In some cases, the second channel clearance signal may include control information or may be transmitted at a power level that is based on a characteristic of the UE.

Abstract: The present disclosure relates to trial scleral lenses, and the resulting scleral lenses, designed for the asymmetric shape of the sclera and/or its chiral properties. In some embodiments, the scleral lenses are also designed for the specific asymmetry associated with different scleral diameters. In addition, as discussed herein, the scleral shape can vary with different conditions of the eye. By designing a set of trial scleral lenses that takes into account these different asymmetric properties of the sclera, a clinician can be more efficient, fitting more eyes with fewer subsequent modifications. The resulting lenses will also achieve a better fit.

Abstract: A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp2-sp3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation.

Abstract: Capsule dosage forms that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the dosage forms comprise at least one pharmaceutically active ingredient, a combination of hydrophilic gelling polymers, at least one organic acid, and at least one disintegrant.

Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.

Abstract: A system described herein may provide a technique for providing status updates relating to the fulfillment of an inter-entity service request. The status updates may be provided by a first entity associated with a first portion of the request, and may include updates indicating the fulfillment of a second portion of the request associated with a second entity. The status updates may be provided via a status tracker user interface (“UI”) that is updated based on the progress of the fulfillment of the request. The status tracker UI may be updated to include input elements to receive updated request parameters in situations where the second entity indicates to the first entity that one or more request parameters are invalid or otherwise in need of correction or modification.

Abstract: The present disclosure relates to trial scleral lenses, and the resulting scleral lenses, designed for the asymmetric shape of the sclera and/or its chiral properties. In some embodiments, the scleral lenses are also designed for the specific asymmetry associated with different scleral diameters. In addition, as discussed herein, the scleral shape can vary with different conditions of the eye. By designing a set of trial scleral lenses that takes into account these different asymmetric properties of the sclera, a clinician can be more efficient, fitting more eyes with fewer subsequent modifications. The resulting lenses will also achieve a better fit.

Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).

Abstract: Methods, systems, and devices for wireless communication are described. Various autonomous uplink control channel configurations may be used for unscheduled uplink transmissions. For example, a user equipment (UE) may initiate an unscheduled uplink transmission and may identify an autonomous uplink control channel configuration for the uplink transmission. The UE may transmit control information and data during an initial transmission time interval of a transmission opportunity according to the control channel configuration, where the control channel configuration control may include a number of different waveforms and payload configurations. For example, an autonomous uplink control channel configuration may include control information frequency division multiplexed or time division multiplexed with data and transmitted in one or more frequency interlaces.

Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).

Abstract: Existing currency validation (CVAL) devices, systems, and methods are too slow, costly, intrusive, and/or bulky to be routinely used in common transaction locations (e.g., at checkout, at an automatic teller machine, etc.). Presented herein are devices, systems, and methods to facilitate optical validation of documents, merchandise, or currency at common transaction locations and to do so in an obtrusive and convenient way. More specifically, the present invention embraces a validation device that may be used alone or integrated within a larger system (e.g., point of sale system, kiosk, etc.). The present invention also embraces methods for currency validation using the validation device, as well as methods for improving the quality and consistency of data captured by the validation device for validation.