Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:

Abstract: A microcode (uCode) hot-upgrade method for bare metal cloud deployment and associated apparatus. The uCode hot-upgrade method applies a uCode patch to a firmware storage device (e.g., BIOS SPI flash) through an out-of-band controller (e.g., baseboard management controller (BMC)). In conjunction with receiving a uCode patch, a uCode upgrade interrupt service is triggered to upgrade uCode for one or more CPUs in a bare-metal cloud platform during runtime of a tenant host operating system (OS) using an out-of-bound process. This innovation enables cloud service providers to deploy uCode hot-patches to bare metal servers for persistent storage and live-patch without touching the tenant operating system environment.

Abstract: Examples herein relate to polling for input/output transactions of a network interface or a storage device, or any peripheral device. Some examples monitor clock cycles spent checking for a presence of input/output (I/O) events and processing I/O events and monitor clock cycles spent checking for presence of I/O events without completing an I/O event. Central processing unit (CPU) core utilization can be based on clock cycles spent checking for a presence of I/O events and processing I/O events and clock cycles spent checking for presence of I/O events without completion of an I/O event. For example, if core utilization is below a threshold, frequency of the core can be reduced for performing polling of I/O events. If core utilization is at or above the threshold, frequency of the core can be increased used to performing polling of I/O events.

Abstract: Apparatuses for computing are disclosed herein. An apparatus may include a set of data reduction modules to perform data reduction operations on sets of (key, value) data pairs to reduce an amount of values associated with a shared key, wherein the (key, value) data pairs are stored in a plurality of queues located in a plurality of solid state drives remote from the apparatus. The apparatus may further include a memory access module, communicably coupled to the set of data reduction modules, to directly transfer individual ones of the sets of queued (key, value) data pairs from the plurality of remote solid state drives through remote random access of the solid state drives, via a network, without using intermediate staging storage. Other embodiments may be disclosed or claimed.

Abstract: A dynamic signal transmission structure based on a hybrid beamforming technology includes a radio-frequency module and an antenna array connected therewith. The radio-frequency module includes one or more radio-frequency link units connected in parallel, the antenna array includes one or more antenna sub-arrays, and each antenna sub-array is connected with one of the radio-frequency modules. The hybrid beamforming technology includes analog and digital beamforming. In this structure, the analog beamforming parameters and the digital beamforming parameters are constant, and the number of radio-frequency link units in the radio-frequency module, the number of antenna sub-arrays in the antenna array, the analog beamforming parameters, and the digital beamforming parameters are in a quantitative relation.

Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:

Abstract: An integrated circuit (IC) package includes a first leadframe having a top surface and a bottom surface. An IC die has an active side coupled to the first leadframe bottom surface and has a back side. A second leadframe has a top surface and a bottom surface. The back side of said IC chip is coupled to the top surface of the second leadframe.

Abstract: The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.

Abstract: The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.

Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.

Abstract: Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid I: and salts thereof, and intermediates useful for the preparation of I.

Abstract: Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).

Abstract: The present invention provides a smart meter including a wireless-communication chip, a wired-communication chip and a microprocessor. The microprocessor receives a data transmission request and determines whether the data type of the data transmission request is mobile data, meter information, or emergency meter information. According to the data type, the microprocessor will select either the wireless-communication chip or the wired-communication chip to transmit the data which corresponds to the data transmission request.

Abstract: Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).

Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.

Abstract: A removable storage cartridge system may include a linear push-push mechanism comprising a carriage having a lock bar and a lock bar spring, and an enclosure having a mounting bracket having a lock guide. The lock guide is configured to interact with the lock bar and spring such that, in response to a first pushing force, reception of the carriage into the mounting bracket positions the carriage into a locked position within the enclosure and, in response to a second pushing force, the carriage is released from the locked position and ejected from the system.

Abstract: A removable storage cartridge system may include a linear push-push mechanism comprising a carriage having a lock bar and a lock bar spring, and an enclosure having a mounting bracket having a lock guide. The lock guide is configured to interact with the lock bar and spring such that, in response to a first pushing force, reception of the carriage into the mounting bracket positions the carriage into a locked position within the enclosure and, in response to a second pushing force, the carriage is released from the locked position and ejected from the system.