Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: A pharmaceutical composition comprises: a) polymorphic form M or tromethamine salt of Compound (1) represented by the following structural formula: and b) a filler. A method of preparing a pharmaceutical composition comprises: providing a mixture of Compound (1) and a filler to form the composition of Compound (1). A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of the pharmaceutical composition.

Abstract: A tactile display apparatus includes a plurality of stimulation pins in contact with a skin; an operating unit for vertically moving the stimulation pins; and a housing accommodating the stimulation pins and the operating unit, the housing having an opening in one surface thereof such that the stimulation pins protrude outward. Here, the plurality of stimulation pins are arranged such that a contact area occupied by front ends of the stimulation pins is smaller than an area occupied by rear ends of the stimulation pins.

Abstract: A semiconductor device assembly or package includes at least one semiconductor device that is positioned adjacent to floating leads. Such an assembly or package may include at least two semiconductor devices that face opposite directions from one another, with each being oriented such that bond pads thereof are at an opposite side of the assembly or package from bond pads of the other. Alternatively, an assembly or package may include a lead assembly with an internal portion, including one or more floating leads, and an external portion that are in planes that are offset relative to one another. Methods for designing lead frames, assemblies, and packages are also disclosed, as are assembly and packaging methods.

Abstract: A traffic signaling device system for motorcyclists comprising a safety brake and running light assembly (34) mounted to a motorcycle jacket (88). The safety brake light has an L.E.D. housing (22) supported by an outboard support member (20) and a leather piece (18). A plurality of snap buttons (16) can be used to secure safety brake light to jacket. The safety brake light has a six-conductor coil cable assembly (12) extending outside of jacket in front thereof is connected to a control box panel (44) so that the rider can view the operation of control box panel in a convenient seated position. At one end of control box is a six-conductor cable (50) which is electrically connected thereof to the existing wiring for a tail and brake light (78), a left turn signal light (80), and a right turn signal light (81) in such vehicles. Other embodiments are described and shown.

Abstract: Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine its salts and solvates thereof are herein set forth, as are pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).

Abstract: The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.

Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.

Abstract: A tactile display apparatus includes a plurality of stimulation pins in contact with a skin; an operating unit for vertically moving the stimulation pins; and a housing accommodating the stimulation pins and the operating unit, the housing having an opening in one surface thereof such that the stimulation pins protrude outward. Here, the plurality of stimulation pins are arranged such that a contact area occupied by front ends of the stimulation pins is smaller than an area occupied by rear ends of the stimulation pins.

Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.

Abstract: A traffic signaling device system for motorcyclists comprising a safety brake and running light assembly (34) mounted to a motorcycle jacket (88). The safety brake light has an L.E.D. housing (22) supported by an outboard support member (20) and a leather piece (18). A plurality of snap buttons (16) can be used to secure safety brake light to jacket. The safety brake light has a six-conductor coil cable assembly (12) extending outside of jacket in front thereof is connected to a control box panel (44) so that the rider can view the operation of control box panel in a convenient seated position. At one end of control box is a six-conductor cable (50) which is electrically connected thereof to the existing wiring for a tail and brake light (78), a left turn signal light (80), and a right turn signal light (81) in such vehicles. Other embodiments are described and shown.

Abstract: A semiconductor device assembly or package includes at least one semiconductor device that is positioned adjacent to floating leads. Such an assembly or package may include at least two semiconductor devices that face opposite directions from one another, with each being oriented such that bond pads thereof are at an opposite side of the assembly from bond pads of the other. Alternatively, an assembly or package may include a lead assembly with an internal portion, including one or more floating leads, and an external portion that are in planes that are offset relative to one another. Methods for designing lead frames, assemblies, and packages are also disclosed, as are assembly and packaging methods.

Abstract: Disclosed is a carrierless chip package for integrated circuit devices, and various methods of make same. In one illustrative embodiment, the device includes an integrated circuit chip comprising an exposed backside surface defining a plane, a plurality of wire bonds that are conductively coupled to the integrated circuit chip, each of the plurality of wire bonds being conductively coupled to a conductive exposed portion, a portion of the conductive exposed portion being positioned in the plane defined by the backside surface, and an encapsulant material positioned adjacent the integrated circuit chip and the plurality of wire bonds.

Abstract: Disclosed is a carrierless chip package for integrated circuit devices, and various methods of make same. In one illustrative embodiment, the device includes an integrated circuit chip comprising an exposed backside surface defining a plane, a plurality of wire bonds that are conductively coupled to the integrated circuit chip, each of the plurality of wire bonds being conductively coupled to a conductive exposed portion, a portion of the conductive exposed portion being positioned in the plane defined by the backside surface, and an encapsulant material positioned adjacent the integrated circuit chip and the plurality of wire bonds.

Abstract: The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).

Abstract: Stacked microelectronic devices and methods for manufacturing microelectronic devices are disclosed herein. An embodiment of one such microelectronic device can include a support member and a first known good microelectronic die attached to the support member. The first die includes an active side, a back side opposite the active side, a first terminal at the active side, and integrated circuitry electrically coupled to the first terminal. The first die also includes a first redistribution structure at the active side of the first die. The microelectronic device can also include a second known good microelectronic die attached to the first die in a stacked configuration such that a back side of the second die is facing the support member and an active side of the second die faces away from the support member. The second die includes a second redistribution structure at the active side of the second die.

Abstract: An assembly method is disclosed that includes providing a substrate, securing a first semiconductor device on a first surface thereof, and superimposing at least a second semiconductor device at least partially over the first semiconductor device is disclosed. An outer peripheral portion of the second semiconductor device overhangs both the first semiconductor device and the substrate. Discrete conductive elements are placed between the outer peripheral portion of the second semiconductor device and a second surface of the substrate. Intermediate portions of the discrete conductive elements pass outside side surface of the substrate. Assemblies and packaged semiconductor devices that are formed in accordance with the method are also disclosed.