Abstract: The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.

Abstract: A method includes cropping a plurality of images from a layout of an integrated circuit, generating a first plurality of hash values, each from one of the plurality of images, loading a second plurality of hash values stored in a hotspot library, and comparing each of the first plurality of hash values with each of the second plurality of hash values. The step of comparing includes calculating a similarity value between the each of the first plurality of hash values and the each of the second plurality of hash values. The method further includes comparing the similarity value with a pre-determined threshold similarity value, and in response to a result that the similarity value is greater than the pre-determined threshold similarity value, recording a position of a corresponding image that has the result. The position is the position of the corresponding image in the layout.

Abstract: A hanging grounded structure is disclosed and includes a housing, a recessed portion and a hanging groove. The housing includes an opening facing a first direction and a lateral wall extended along a second direction. The lateral wall has a top edge located at a periphery of the opening. The recessed portion is recessed inwardly on the lateral wall. The hanging groove is disposed on the lateral wall and located in the recessed portion. A grounded wire is hung on the housing through the hanging groove. The hanging groove includes a starting point located at the top edge and an ending point. A curved path is formed from the starting point to the ending point. The grounded wire is hung from an interior of the housing. An end of the grounded wire is disposed in the recessed portion through the hanging groove.

Abstract: A semiconductor device, a method of fabricating the semiconductor device and a memory are disclosed. In the provided semiconductor device, bit line contact plugs partially reside on insulating material layers in gate trenches in active areas and thus can come into sufficient contact with the active areas. This ensures good electrical transmission between the bit line contact plugs and the active areas even when there are internal voids in the bit line contact plugs. Such bit line contact plugs allowed to contain internal voids can be fabricated in an easier and faster manner, thus allowing a significantly enhanced memory fabrication throughput.

Abstract: A semiconductor structure and a method for forming a semiconductor structure are provided. The semiconductor structure includes a substrate; a gate electrode disposed within the substrate; a gate dielectric layer disposed within the substrate and surrounding the gate electrode; a plurality of first protection structures disposed over the gate electrode; a second protection structure disposed over the gate dielectric layer; and a pair of source/drain regions on opposing sides of the gate dielectric layer.

Abstract: Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

Abstract: A system for acceleration adjustment of machine tool at rapid traverse includes a signal measurement module, a signal judgment module and an acceleration optimization module. The machine tool has a servo motor and a working platform. The signal measurement module measures signals while the servo motor drives the working platform from a first specific position to a second specific position, or from the second specific position back to the first specific position. The signal judgment module judges whether the actual maximum current value of the motor is equal to the manufacturer's specification according to the signals; and if negative, the acceleration optimization module calculates and optimizes an axial acceleration till an optimal value is achieved. Then, a curve smoothing time of the optimal acceleration is calculated and optimized by the acceleration optimization module. In addition, a method for acceleration adjustment of machine tool at rapid traverse is provided.

Abstract: An imaging lens driving module includes a base, a casing, a driving mechanism and a damping element. The base has an opening, and the casing has a central aperture corresponding to the opening. The casing includes a plastic frame portion and a metal structure portion. The plastic frame portion is coupled to the base. The metal structure portion has a plurality of pins extending towards the base. The driving mechanism is disposed in the casing. The driving mechanism is configured to drive the lens unit to move in a direction parallel to an optical axis. The damping element is connected to the pins and the lens unit. The metal structure portion is insert-molded with the plastic frame portion to form the casing. The pins are located closer to the optical axis than the other part of the metal structure portion to the optical axis.

Abstract: An immunochromatographic detection device adapted for detecting an analyte in a specimen includes a surface-modified cellulose membrane, a detection unit, and a substrate. The surface-modified cellulose membrane includes opposite top and bottom surfaces, cellulose fibers, and an anti-biofouling acrylic copolymer that is bonded to the cellulose fibers. The detection unit is disposed on the top surface of the cellulose membrane, is configured to interact with the specimen, and includes a diffusion layer, a capturing layer, a detection layer, a control line layer, and an absorbent layer. The substrate is disposed on the bottom surface of the surface-modified cellulose membrane.

Abstract: A cooling system includes a rotor structure, a first end plate and a second end plate. The rotor structure includes a silicon steel, magnets and a shaft. The first end plate is at a first end of the silicon steel, and the first end plate is recessed with a first-shaped oil groove and a second-shaped oil groove. The second end plate is at a second end of the silicon steel, and the second end plate is recessed with a first-shaped oil groove and a second-shaped oil groove. The first-shaped oil groove of the first end plate is connected to the second-shaped oil groove of the second end plate to form a first cooling path. The second-shaped oil groove of the first end plate is connected to the first-shaped oil groove of the second end plate to form a second cooling path.

Abstract: A photographing module includes a lens assembly, a reflection element, an image sensor, and lens element, reflection element and image sensor driving modules. An axial voice coil motor of the lens element driving module moves the lens assembly along a lens optical axis. A rotating connection part and a curved recess structure are disposed between a holder and a carrier movable relative to the holder. A lateral voice coil motor of the reflection element driving module drives the carrier carrying the reflection element to rotate around an axis passing through the rotating connection part. A plurality of rollable elements are located between and in contact with the fixed member and the movable plate. A lateral voice coil motor of the image sensor driving module drives the movable plate carrying the image sensor to move based on a dynamic axis orthogonal to the lens optical axis.

Abstract: A solid state disk, a data transmitting method and an intermediary controller thereof are provided. The solid state disk includes at least two flash memories, a SSD controller and an intermediary controller. The intermediary controller is connected between the flash memories and the SSD controller. The intermediary controller includes at least two flash interfaces, a customized interface and a data buffering unit. The flash interfaces are connected to the flash memories. The customized interface is connected to the SSD controller. The intermediary controller has a first clock domain and a second clock domain. The first clock domain is used for transmitting data from the flash memories to the data buffering unit. The second clock domain is used for transmitting data from the data buffering unit to the SSD controller. A frequency of the second clock domain is higher than a frequency of the first clock domain.

Abstract: A charging method with hysteresis includes the steps of: performing a pre-determination process to check whether the battery temperature of a battery cell is higher than or equal to a predetermined temperature; if the battery temperature is higher than or equal to the predetermined temperature, enabling a hysteresis mechanism; Upon the hysteresis mechanism, initially charging the battery cell with a small charging current; performing a first determination process to check whether the battery temperature decreases to a first threshold temperature; if the battery temperature decreases to the first threshold temperature, charging the battery cell with a large charging current; performing a second determination process to check whether the battery temperature increases to a second threshold temperature; and if the battery temperature increases to the second threshold temperature, charging the battery cell with the small charging current.

Abstract: A semiconductor device structure includes a first dielectric layer disposed over a semiconductor substrate, and a second dielectric layer disposed over the first dielectric layer. The semiconductor device structure also includes a first conductive plug disposed in the first dielectric layer. A top surface of the first conductive plug is greater than a bottom surface of the first conductive plug. The semiconductor device structure further includes a second conductive plug disposed in the second dielectric layer and directly over the first conductive plug.

Abstract: A breathable water resistant film provided by the present disclosure includes a base cloth and a nanofiber layer disposed on the base cloth, wherein the nanofiber layer is formed by an electrospinning solution including a first additive and a second additive. The first additive includes a nylon copolymer and an alcohol, and the second additive includes a polysilazane resin and a perfluoropolyether-modified polysilazane resin.

Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.

Abstract: An electronic device and a method for determining medical images are provided. The method includes: obtaining an input image; inputting the input image into a first machine learning model to generate a labeled image, wherein the labeled image includes a plurality of area images; inputting the labeled image into a second machine learning model to generate a plurality of area determination data corresponding to the plurality of area images; and displaying a determination result including the plurality of area determination data.

Abstract: A semiconductor device is provided. The semiconductor device includes a first field effect device on a first region of a substrate, wherein a first gate structure and an electrostatic discharge device on a second region of the substrate, wherein a second gate structure for the electrostatic discharge device is separated from the substrate by the bottom dielectric layer, and a second source/drain for the electrostatic discharge device is in electrical contact with the substrate, wherein the second source/drain is doped with a second dopant type.

Abstract: A method for fabricating a semiconductor device includes providing a substrate; forming a bit line conductive layer on the substrate and a bit line inner capping layer on the bit line conductive layer to form a bit line structure; a bit line structure; forming a bit line spacer capping layer covering the bit line structure; forming a cell contact adjacent to the bit line structure; forming a blanket pad layer on the bit line spacer capping layer and the cell contact; forming a plurality of pad openings along the blanket pad layer and extending to the bit line spacer capping layer and the bit line inner capping layer to turn the blanket pad layer into a plurality of landing pads; and selectively forming a sealing layer to form a plurality of air gaps between the bit line conductive layer and the plurality of landing pads.

Abstract: The present application discloses a semiconductor device and a method for fabricating the semiconductor device. The semiconductor device includes a substrate; a drain region positioned in the substrate; a common source region positioned in the substrate and opposing to the drain region; a bit line structure including a bit line conductive layer positioned on the substrate and electrically coupled to the common source region; a cell contact positioned on the substrate, adjacent to the bit line structure, and electrically connected to the drain region; a landing pad positioned above the bit line conductive layer and electrically connected to the cell contact; and an air gap positioned between the landing pad and the bit line conductive layer.